1.논문 제목: Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells 2.저자명: Shengjie Peng, Guodong Chen, K. N. Yu, Yue Feng, Lele Zhao, Miaomiao Yang, Wei Cao, Waleed Abdelbagi Ahmed Almahi, Mingyu Sun, Yuan Xu, Ye Zhao, Cheng Cheng, Fengqin Zhu, Wei Han. 3.Publish: 12 February 2024 4.DOI: 10.1186/s12964-023-01382-z 5.Abstract: Though (1S, 3R)-RSL3 has been used widely

Governa et al., Proceedings of the National Academy of Sciences, 2022 DOI: 10.1073/pnas.2114456119 Therapeutic strategies directed at the tumor surfaceome (TS),including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have deve

1. 논문 제목: Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain 2. 저자명: Fei-Cheng Yang, Chuan Wang, Jiang Zhu, Qu-Jing Gai, Min Mao, Jiang He, Yan Qin, Xiao-Xue Yao, Yan-Xia Wang, Hui-Min Lu, Mian-Fu Cao, Ming-Min He, Xian-Mei Wen, Ping Leng, Xiong-Wei Cai, Xiao-Hong Yao, Xiu-Wu Bian and Yan Wang 3. 출처 및 게재 (발행일): Laboratory Investigation, 25 Feb

1.논문 제목: Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. 2.저자명: Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent Stockwell, Guido Kroemer, Rui Kang, Daolin Tang. 3.Publish: Science Translational Medicine, 1 November, 2023 4.DOI: 10.1126/scitranslmed.adg3049 5.Abstract: Current ferroptosis inducers effectively kill cancer cells by inhibiting GPX4 but also damage immune cells,

1.논문 제목: Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma 2.저자명: Xinyu He, Yubing Zhou, Wenjing Chen, Xiaokun Zhao, Lina Duan, Hao Zhou, Mingzhu Li, Yin Yu, Jimin Zhao, Yaping Guo, Huihui Gu, Yanan Jiang, Zigang Dong, Kangdong Liu 3.Publish: 25 February 2023 4.DOI: https://doi.org/10.1038/s41388-023-02636-3 5.Abstract: Targeted therapy attempts are needed to enhance esophageal squamous c

Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z. ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer. J Med Chem. 2023 May 11;66(9):6070-6081. doi: 10.1021/acs.jmedchem.2c01909. Proteolysis-targeting chimera (PROTAC) technology has emerged as a potential strategy to degrade “undruggable” proteins in recent years. Nrf2, an aberrantly activated transcription factor in cancer, is generally considered undruggable as lacking active sites or allosteric pockets. Here, we

1.논문 제목: Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma 2.저자명: Songlei Zhou, Yukun Huang, YuChen, Yipu Liu, Laozhi Xie, YangYou, Shiqiang Tong, Jianpei Xu, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, Hongzhuan Chen & Jun Chen 3. 출처 및 게재 (발행일): Nature communications, 26 January 2023 4. DOI: https://doi.org/10.1038/s41467-023-35957-8 5. Abstract: The limited benefits of immunotherapy against glioblastoma (GBM) is

1.논문 제목: NRF2 promotes ferroptosis sensitivity in temozolomide-resistant glioblastoma cells through MRP1/ABCC1 regulation 2.저자명: Isabela de Souza, Luiza K. S. Moreira, Camila B. Gomes, Marina T. Andrade, Bruna C. Carvalho, Mariana M. Silva, Bruno F. M. M. Pereira, Mariana T. Latancia, Daniela Menck, Marcelo Lancellotti, Luiz R. G. Gomes, C. R. R. Rocha 3.Publish: July 1, 2022 4.DOI: 10.1038/s41419-022-05044-9 5.Abstract: Glioblastoma frequently develops resistance to temozolo

1.논문 제목: Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery 2.저자명: Lingling Shen, Jian Fang, Lulu Liu, Fei Yang, Jeremy L. Jenkins, Peter S. Kutchukian, He Wang 3.Publish: 21 March 2024 4.DOI: https://doi.org/10.1186/s13321-024-00829-w 5.Abstract: We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit-finding activity in the drug discovery process.

1.논문 제목: Microglial SRGN aggravates neuroinflammation after ischemic stroke via interacting with CD44 2.저자명: Yi Qian, Lixuan Yang, Jian Chen, Na Zhang, Yuting Gu, Xiaofei Bao, Shuxuan Xie, Hai Yu, Yanchun Chen, Chao Zhao, Yun Xu 3.출처 및 게제일: Journal of Neuroinflammation, 29 January 2024 4.DOI: http://dio.org/10.1186/s12974-024-03026-6. 5.Abstract: Ischemic stroke triggers severe neuroinflammation driven largely by activated microglia. This study investigated the role of Sergly

1.논문 제목: Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy 2.저자명: Haoge Zhang, JiaMiao, LinGao, Xuhong Yang, Zhengcheng Yun, LeiDong, Wanqing Cheng, Yuqi Wang, Hui Yang, Ying Zhou, Yini Zhu & Jinbing Xie 3.출처 및 게제일: Nature communications, 11 April 2026 4.DOI: https://doi.org/10.1038/s41467-026-71646-y 5.Abstract: Bispecific immune cell engagers, particularly bispecific T-cell engagers, show limited effic

1.논문 제목: Activity cliff-aware reinforcement learning for de novo drug design 2.저자명: Xiuyuan Hu, Guoqing Liu, Yang Zhao, Hao Zhang 3.Publish: 21 April 2025 4.DOI: https://doi.org/10.1186/s13321-025-01006-3 5.Abstract: The integration of artificial intelligence (AI) in drug discovery offers promising opportunities to streamline and enhance the traditional drug development process. One core challenge in de novo molecular design is modeling complex structure-activity relationship

Weng X, Maxwell-Warburton S, Hasib A, Ma L, Kang L. The membrane receptor CD44: novel insights into metabolism. Trends Endocrinol Metab. 2022 May;33(5):318-332. doi: 10.1016/j.tem.2022.02.002. Epub 2022 Mar 4. PMID: 35249813. 초록 CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its essential role in physiological activities in normal cells and pathological activities in cancer cells, such as cell proliferation, adhesion, and migration; angio

1. 논문 제목: Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma. 2. 저자명: JongHoon Ha, Yifan Wang, YifanMa, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L. Edwards, Mengyu Chang, Yen-Tzu Chang, XiaotianWang, MauriceDufilho, Michelle Najarro Torres, Shannon McCabe, Weiye Deng, Adam J. Grippin, Jeffrey S. Weinberg, ShaanM. Raza, Franco DeMonte, Ian E. McCutcheon, Sujit Prabhu, Sherise D. Ferguson, Chibawanye I. Ene, Kadir Akdem

1.논문 제목: Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition 2.저자명: Hongyu Ding, Zihong Chen, Katherine Wu, Shih Ming Huang, Warren L. Wu, Sarah E. LeBoeuf, Ray G. Pillai, Joshua D. Rabinowitz, Thales Papagiannakopoulos. 3.발행일: Science Advances,17 Nov 2021 4.DOI: 10.1126/sciadv.abk1023 5.Abstract: The KEAP1/NRF2 signaling pathway is frequently activated in cancer and promotes antioxidant defense and metabolic adaptation. To identify metabolic vulne

1.논문 제목: CSearch: chemical space search via virtual synthesis and global optimization 2.저자명: Hakjean Kim, Seongok Ryu, Nuri Jung, Jinsol Yang, Chaok Seok 3.Publish: 05 December 2024 4.DOI : https://doi.org/10.1186/s13321-024-00936-8 5.Abstract: The two key components of computational molecular design are virtually generating molecules and predicting the properties of these generated molecules. This study focuses on an effective method for molecular generation through virtual

1. 논문 제목: Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity. 2. 저자명: Yonghua Li, Min Sheng, Weijie Li, Simin Liu, Botao Wang, Bing Liu, Mei Luo, Xiao Zhou, Qiaoxi Xia, Shihong Hong, Ziyuan Zheng, Shi-Yuan Cheng, Xiaobing Jiang, JunjunLi &Tianzhi Huang 3. 출처 및 게재 (발행일): Nature communications, 13 December 2025 4. DOI: https://doi.org/10.1038/s41467-025-67119-3 5. Abstract: Chaperone-mediated autophagy (CMA

1.논문 제목: uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target 2.저자명: William T. Maich, Muhammad Vaseem Shaikh, Anish Puri, Martin A. Rossotti, Shan Grewal, Aapti Khanna, Alisha Anand, Nicholas Mikolajewicz, Mathieu P. Seyfrid, Dillon A. McKenna, Minomi Subapanditha, Daniel Mobilio, Greg Hussack, Joey G. Sheff, Jennifer J. Hill, Mo Taleb, Jacek M. Kwiecien, Sabra Salim, Neil Savage, Bill Wang, Sunjay Sharma, Abdelsimar Omar, Chirayu C

1.논문 제목: Small molecule drug discovery for glioblastoma treatment based on bioinformatics and cheminformatics approaches 2.저자명: Liya Feng, Sha Zhu, Jian Ma, Jing Huang, Xiaoyan Hou, Qian Qiu, Tingting Zhang, Meixia Wan, Juan Li 3.Publish: 12 April 2024 4.DOI: https://doi.org/10.3389/fphar.2024.1389440 5.Abstract: Background: Glioblastoma (GBM) is a common and highly aggressive brain tumor with a poor prognosis for patients. It is urgently needed to identify potential small

Cell, Vol. 189, pp. 1341–1355, March 5, 2026 Gao X, Liu X, Wang N et al. https://www.cell.com/cell/fulltext/S0092-8674%2825%2901421-7#fig1 초록 The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells using drug-loaded nanoparticles (NPs) and leveraged their unique migration mechanism through skull-

1.논문제목: Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities. 2.저자명: Jun Lin, Chunpeng Chen, Shouzhen Li, Liu Chen, Minghao Fang, Shuqi Fu, Kaixing Chen, Hao Xu, Fenghuan Zhang, Rirui Wang, Chen Jiang, Meifang Tang, Zitian Liu, Shuyan Wang, Ke Liu, Chaoshi Niu, Bin Li, Xu Liu, Chuandong Cheng, Ai-Hui Tang & Kun Qu 3.발행일: Nature neuroscience, 16 April 2026 4.DOI: https://doi.org/10.1038/s41593-026-02265-5

1.논문 제목: Liposomal Nanomaterials: A Rising Star in Glioma Treatment 2.저자명: Yu Gan, Yingying Yu, Huizhe Xu, Haozhe Piao. 3.Publish: 2024 July 4.DOI: 10.2147/IJN.S470478 5.Abstract: Glioma remains one of the most aggressive primary tumors of the central nervous system, with limited therapeutic efficacy due to the presence of the blood–brain barrier (BBB). Conventional treatments such as surgery, radiotherapy, and chemotherapy fail to significantly improve patient survival. Rece

1.논문제목 : Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma 2.저자명: Susan Costantini, Isabella Romeo, Giulia Fanelli, Maria Serena Roca, Gianmarco Gualtieri, Palmina Bagnara, Andrea Polo, Elena Di Gennaro, Francesco Ortuso, Stefano Alcaro, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi, Claudia Abbruzzese 3.Pub lish: 2025 Dec 8 4.DO I : 10.1186/s12967-025-07444-9 5.Abstract 5-1 Background: Glioblastoma (GBM

Emma Martell 1,2,9, Helgi Kuzmychova 1,3,9, Ujala Chawla1 , Akaljot Grewal1,3, Charul Jain1,3, Chitra Venugopal4,5, Christopher M. Anderson2,6, Sheila K. Singh 4,5,7 and Tanveer Sharif 1,3,8 Cell Death and Disease (2026) 17:348 ; https://doi.org/10.1038/s41419-026-08646-9 초록 Glioblastoma (GBM), the most common malignant brain tumor in adults, remains a highly lethal and incurable cancer, with a 5-year survival rate below 10%. Standard-of-care involves surgical resection follo

1.논문 제목: Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme 2.저자명 : Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Alfredo Quinones-Hinojosa & Debabrata Mukhopadhyay 3.Pub lish: Communi

1.논문 제목 : The regulations of telomerase reverse transcriptase (TERT) in cancer 2.저자명: Mingdi Liu , Yuning Zhang , Yongping Jian , Liting Gu , Dan Zhang , Honglan Zhou , Yishu Wang & Zhi-Xiang Xu 3.Pub lish: C ell death & disease , January, 2024 4.DO I: 10.1038/s41419-024-06454-7. 5.Abstract: Telomerase reverse transcriptase (TERT) is a key regulator of cancer progression by maintaining telomere length and enabling cells to bypass replicative senescence. In most canc

1.논문 제목: CB‑Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting 2.저자명: Yang Liu, Xiaocong Yang, Jianhong Gan, Shuang Chen, Zhi‑Xiong Xiao, Yang Cao 3.Pub lish: 2022 Jul 5 4.DO I: 10.1093/nar/gkac394 5.Abstract: Protein-ligand blind docking is a powerful method for exploring the binding sites of receptors and the corresponding binding poses of ligands. It has seen wide applications in pharmaceutical and biolo

Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton E, Pastuszka MK, Sigler JJ, Tran E, Hee K, McLaughlin J, Ambrus-Aikelin G, Pollock J, Abraham RT, Kinsella TM, Simon GM, Major MB, Weinstein DS, Patricelli MP. Cancer Discov . 2025 Dec 19. doi: 10.1158/215

1.논문 제목: Base barrier cells provide compartmentalization of choroid plexus, brain and CSF 2.저자명: Daan Verhaege, Clint De Nolf, Lore Van Acker, Wouter Claeys, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Pieter Dujardin, Ward De Spiegelaere, Esther Hoste, Fleur Boone, Hart G. W. Lidov, Neil Dani, Julia Derk, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Saskia Lippens, Maria K. Lehtinen, Julie Siegenthaler, Lien Van Hoecke Roosmarijn E. Vandenbroucke 3.출처 및

1.논문 제목: Strategies for blood–brain barrier rejuvenation and repair 2.저자명: Matthew J. Campbell, Daniel A. Nation, Anne Eichmann, Christer Betsholtz, Berislav V. Zlokovi 3.Pub lish: Nature Reviews Drug Discovery , 2026 4.DO I: 10.1038/s41573-025-01364-5 5.Abstract: Blood–brain barrier (BBB) dysfunction is a common feature of many neurological diseases such as Alzheimer disease, stroke and other neurodegenerative disorders. Although the BBB plays a crucial role in maintainin