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Neurologic recovery & Rejuvenation
Basic Research News
Molecular signatures of normal pressure hydrocephalus: a large-scale proteomic analysis of cerebrospinal fluid.
Aida Kamalian, Siavash Shirzadeh Barough, Sara G. Ho, Marilyn Albert, Mark G. Luciano, Sevil Yasar Abhay Moghekar Fluids and Barriers of...
The blood–brain barrier: Structure, regulation and drug delivery
Wu, D., Chen, Q., Chen, X. Signal Transduction and Targeted Therapy volume 8, Article number: 217 (2023) https://doi.org/10.1038/s41392-0...
Therapeutic approaches targeting the neurotensin receptors
Malliga R. Iyer and George Kunos Expert Opin Ther Pat . 2021 May;31(5):361-386 DOI: 10.1080/13543776.2021.1866539 Abstract Introduction:...
The changing landscape of medicinal chemistry optimization
Anita Rácz, Levente M. Mihalovits, Maximilian Beckers, Nikolas Fechner, Nikolaus Stiefl, Finton Sirockin, William McCoull, Emma...
Different states of stemness of glioblastoma stem cells sustain glioblastoma subtypes indicating novel clinical biomarkers and high-efficacy customized therapies
Alberto Visioli1†, Nadia Trivieri2†, Gandino Mencarelli2 , Fabrizio Giani1 , Massimiliano Copetti3 , Orazio Palumbo4 , Riccardo Pracella2...
RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus.
Xue Pang1, Lin Gu1, Qiu-Ying Han, Jia-Qing Xing, Ming Zhao, Shao-Yi Huang, Jun-Xi Yi, Jie Pan, Hao Hong Wen Xue, Xue-Qing Zhou, Zhi-Hui...
The choroid plexus links innate immunity to CSF dysregulation in hydrocephalus
Stephanie M. Robert, Benjamin C. Reeves, Emre Kiziltug, Phan Q. Duy, Jason K. Karimy, M. Shahid Mansuri, Arnaud Marlier, Garrett...
Discovery of new LXRβ agonists as glioblastoma inhibitors
Hao Chen, Ziyang Chen, Zizhen Zhang, Yali Li, Shushu Zhang, Fuqiang Jiang, Junkang Wei, Peng Ding, Huihao Zhou, Qiong Gu, Jun Xu 2020 May...
A route for cerebrospinal fluid flow through leptomeningeal arterial–venous overlaps enables macromolecule and fluid shunting
Benjamin A. Plog, Kyungdeok Kim, Daan Verhaege, Min Woo Kim, Zachary Papadopoulos, Krikor Dikranian, Taitea Dykstra, Jay Cao, Richard J....
Traumatic brain injury promotes neurogenesis at the cost of astrogliogenesis in the adult hippocampus of male mice
Bielefeld P, Martirosyan A, Martín-Suárez S, Apresyan A, Meerhoff GF, Pestana F, Poovathingal S, Reijner N, Koning W, Clement RA, Van der...
Progressive histological and behavioral deterioration of a novel mouse model of secondary hydrocephalus after subarachnoid hemorrhage.
Xuehai Deng, Jianlin Ding, Chang Liu, Zhong Wang, Junchi Wang, Qiyue Duan, Weida Li, Xinlong Chen, Xiaoping Tang & Long Zhao.Scientific...
Efficient Delivery of Lomitapide using Hybrid Membrane-Coated Tetrahedral DNA Nanostructures for Glioblastoma Therapy
Mingming Song et al. Advanced Materials , 2024 DOI: 10.1002/adma.202311760 Figure 2. Preparation and characterization of RFA NPs...
Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
Hanbing Xu , Masakazu Miyajima, Madoka Nakajima, Ikuko Ogino, Kaito Kawamura, Chihiro Akiba, Chihiro Kamohara, Koichiro Sakamoto,...
Increased CSF drainage by non-invasive manipulation of cervical lymphatics
Jin, H., Yoon, JH., Hong, S.P. et al. Nature (2025). https://doi.org/10.1038/s41586-025-09052-5 Abstract Cerebrospinal fluid (CSF) in...
Repositioning of Small Molecules through the Inverse Virtual Screening in silico Tool: Case of Benzothiazole-Based Inhibitors of Soluble Epoxide Hydrolase (sEH)
Erica Gazzillo, Ester Colarusso, Assunta Giordano, Maria Giovanna Chini, Marianna Potenza, Robert Klaus Hofstetter, Maria Iorizzi, Oliver...
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