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Clinical Research News


Novel drug targets in 2024
By Sorin Avram , Liliana Halip , Ramona Curpan & Tudor I. Oprea BIOBUSINESS BRIEFS 04 April 2025 Nature reviews drug discovery In 2024,...

Clinical and Genomic Predictors of Adverse Events in Newly Diagnosed Glioblastoma
Mary Jane Lim-Fat # 1 , J Bryan Iorgulescu # 2 , Rifaquat Rahman 3 , Varun Bhave 4 , Alona Muzikansky 5 , Eleanor...

A window-of-opportunity trial reveals mechanisms of response and resistance to navtemadlin in patients with recurrent glioblastoma
Veronica Rendo1,2,3,4,5*†, Eudocia Q. Lee1,3,6*†, Connor Bossi7, Nicholas Khuu1,2,4, Michelle A. Rudek8‡, Sangita Pal1,2,3,4, Narmen...

Contemporary prognostic signatures and refined risk stratification of gliomas: An analysis of 4400 tumors
Hia S. Ghosh‡, Ruchit V. Patel‡, , Eleanor Woodward, Noah F. Greenwald, Varun M. Bhave, Eduardo A. Maury, Gregory Cello, Samantha E....

Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy
Miki Kawazoe, 1,2 Shunsuke Koga, 1 Hiroaki Sekiya, 1 Keith Anthony Josephs, 3 Neill R. Graff-Radford,4 and Dennis W. Dickson 5 Neurology:...

Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers
de Geus MB, Wu CY, Dodge H, Leslie SN, Wang W, Lam TT, Kahle KT, Chan D, Kivisäkk P, Nairn AC, Arnold SE, Carlyle BC. Neurology. 2025 Mar...

Efficacy of Adding Veliparib to Temozolomide for Patients With MGMT-Methylated Glioblastoma: A Randomized Clinical Trial
Shu-Ling Chong, M.D. Yanan Zhu, PhD. et al. 2025년 3월 11일 JAMA Netw Open 2025; 8(3):e250438 DOI: 10.1001/jamanetworkopen.2025.0438...

Direct oral anticoagulants versus no anticoagulation for the prevention of stroke in survivors of intracerebral haemorrhage with atrial fibrillation (PRESTIGE-AF)
Veltkamp, RolandNaegel, Steffen et al. The Lancet, Volume 405, Issue 10482, 927 - 936 https://www.thelancet.com/journals/lancet/article/P...

Safety and efficacy of atorvastatin for rebleeding in cerebral cavernous malformations (AT CASH EPOC): a phase 1/2a, randomised placebo-controlled trial
Awad, Issam A et al. The Lancet Neurology, Volume 24, Issue 4, 295 - 304 https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(...

Association Between Changes in White Matter Volume Detected With Diffusion Tensor–Based Morphometry and Motor Recovery After Stroke
Matthew A. Edwardson, 1,2 Amritha Nayak,3,4,5 M. Okan Irfanoglu, 3 Marie L. Luby, 6 Lawrence L. Latour, 6 and Carlo Pierpaoli 3 Neurology...

Brain Death/Death by Neurologic Criteria Determination
Ariane Lewis, M.D; Matthew P. Kirschen, M.D, PhD 2021년 10월 1일 Continuum (Minneap Minn). 2021Oct 1;27(5):1444-1464. DOI:...

General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke
Christian Heitkamp, Fabian Flottmann, Tobias D. Faizy, Alexander Heitkamp, Christian Thaler, Vincent Geest, Maximilian Schell, Helge C....

Ventilation practices in acute brain injured patients and association with outcomes: the VENTIBRAIN multicenter observational study
Robba C, Giardiello D, Almondo C, Asehnoune K, Badenes R, Cinotti R, Elhadi M, Graziano F, Helbok R, Jiang L, Chen W, Laffey JG, Messina...

Clinical Outcomes of Hypertonic Saline vs Mannitol Treatment Among Children with Traumatic Brain Injury
Shu-Ling Chong, M.D. Yanan Zhu, PhD. et al. 2025년 3월 11일 JAMA Netw Open 2025; 8(3):e250438 DOI: 10.1001/jamanetworkopen.2025.0438...

Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury
Jan Claassen. M.D. et al. 2019년 6월 26일 N Engl J Med 2019;380:2497-2505. DOI: 10.1056/NEJMoa1812757 Background Brain activation in...
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