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Clinical Research News



Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas A Randomized Clinical Trial
Chengcheng Guo, MD, PhD 1 ; Qunying Yang, MD, PhD 1 ; Pengfei Xu, MD, PhD 1 Meiling Deng, MD, PhD 2 ; Taipeng Jiang, MD, PhD 3 ; Linbo Cai, MD, PhD 4 ; Jibin Li, MD, PhD 5 ; Ke Sai, MD, PhD 1 ; Shaoyan Xi, MD, PhD 6 ; Hui Ouyang, MD, PhD 7 ; Mingfa Liu, MD, PhD 8 ; Xianming Li, MD, PhD 9,10 ; Zihuang Li, MD, PhD 9,10 ; Xiangrong Ni, MD, PhD 1 ; Xi Cao, BSN 1 ; Cong Li, MD, PhD 11,12 ; Shaoxiong Wu, MD, PhD 2 ; Xiaojing Du, MD, PhD 2 ; Jun Su, MD, PhD 13 ; Xi
SOFA-2: 장기부전 평가의 새로운 시대
JAMA 2025. Ranzani et al.-30년 만의 전면 개정


Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Otavio T. Ranzani, MD, MSc, PhD 1,2,3 ; Mervyn Singer, MD 4 ; Jorge I. F. Salluh, MD, PhD 5 et al 2025년 10월 29일 JAMA Published Online: October 29, 2025 DOI: 10.1001/jama.2025.20516 Abstract Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture current c


Primary brain tumours in adults
Prof Martin J van den Bent, MD a m.vandenbent@erasmusmc.nl ∙ Marjolein Geurts, MD a ∙ Pim J French, PhD a ∙ ...


Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria
The VasCog-2-WSO Criteria Consortium 2025년09월16일 JAMA Neurol . Published online: September 16, 2025. Doi: 10.1001/jamaneurol.2025.3242...


A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus
Mark G. Luciano, M.D., Ph.D. et al. 2025년 9월 16일 N Engl J Med DOI: 10.1056/NEJMoa2503109 Abstract Background Idiopathic...


White Matter Tract Density Index Prediction Model of Overall Survival in Glioblastoma
Alessandro Salvalaggio, MD, PhD 1,2 ; Lorenzo Pini, PhD 1,2 ; Matteo Gaiola, MD 1 et al JAMANeurol.2023;80(11):1222-1231.doi:10.1001/j...


Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria
Michaël Chassé, MD, PhD1,2,3 ; Jai Jai Shiva Shankar, MD, MSc4,5 ; Dean A. Fergusson, PhD6,7 ; et al 2025년06월13일 JAMA Neurol...


Depot Medroxyprogesterone Acetate and Risk of Meningioma in the US
Tianqi Xiao, MD1,2 ; Pranav Kumar, BA1,2 ; Mina Lobbous, MD, MSPH2,3 ; et al 2025년09월02일 JAMA Neurol . Published online: September 2,...


Incidence and Prevalence of Frontotemporal DementiaA Systematic Review and Meta-Analysis
Daniele Urso, MD, MPH1,2 ; Stefano Giannoni-Luza, MD, MPH1 ; Carol Brayne, MD, MSc3 ; et al 2025년09월08일 JAMA Neurol . Published online:...


Gadolinium-Enhanced Aneurysm Wall Imaging and Risk of Intracranial Aneurysm Growth or Rupture
Qingyuan Liu, MD1 ; Xin Nie, MD1 ; Mervyn D. I. Vergouwen, MD, PhD2 ; et al 2025년09월08일 JAMA Neurol . Published online: September 8,...


Minimally Invasive Surgery vs Medical Management Alone for Intracerebral Hemorrhage The MIND Randomized Clinical Trial
Adam S. Arthur, MD, MPH1 ; Babak S. Jahromi, MD2 ; Paul S. Saphier, MD3,4 et al 2025년 9월 2일 JAMA Neurol . September 2, 2025 DOI:...


Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial
Adam M Sonabend 1 , Andrew Gould 2 , Christina Amidei 2 , Rachel Ward 2 , Karyn A Schmidt 2 , Daniel Y Zhang 3 , ...


Intracranial Hemorrhage in Patients With Stroke After Endovascular Treatment With or Without IV AlteplaseAn Individual Participant Data Meta-Analysis
Yu Zhou, MD1,2 ; Lei Zhang, MD1 ; Fabiano Cavalcante, MD, MSc3 ; et al 2025년 8월 11일 JAMA Neurol . August 11, 2025 DOI:...


Short-course hypofractionated proton beam therapy, incorporating 18F-DOPA PET and contrast-enhanced MRI targeting, for patients aged 65 years and older with newly diagnosed glioblastoma: a single-arm
Prof Sujay Vora, MD a ∙ Deanna Pafundi, PhD d ∙ Molly Voss, BS e ∙ Matthew Buras, MS e ∙ Jonathan Ashman, MD a ∙ Prof Bernard...
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