Stephen J Bagley 1 2 3, Arati S Desai 4 5 6, Joseph A Fraietta 7 8, Dana Silverbush 9, Daniel Chafamo 6, Nelson F Freeburg 9, Gayathri Konanur Gopikrishna 9, Andrew J Rech 7 10, Ali Nabavizadeh 11, Linda J Bagley 6 11, Jungmin Park 5 6 7, Danuta Jarocha 7, Rene Martins 7, Nicolas Sarmiento 7, Eileen Maloney 5 6, Lester Lledo 7, Carly Stein 7, Amy Marshall 7, Rachel M Leskowitz 7, Julie K Jadlowsky 7, Shane Mackey 7, Shannon Christensen 7, Bike Su Oner 7, Gabriela Plesa 7, And

Pierre Bouzat 1,5,✉, Aaron Blandino-Ortiz 2, Antoine Vilotitch 3 et al 2026년09월28일 Crit Care.September 28, 2026. DOI:10.1186/s13054-026-06360-8 Abstract Background Automated pupillometry quantifies the pupillary light reflex in acute brain injury. The neurological pupil index (NPi) is the established composite index and carries prognostic value. A second index from a different device, the quantitative pupil index (QPi), has recently become available, but whether it conveys

Jorien B E Janssen 1,#, Cyrillo G Brahm 2,#, Chantal M L Driessen 3, Janine Nuver 4, Mariette Labots 5, Mathilde C M Kouwenhoven 6, Esther Sanchez Aliaga 7, Roelien H Enting 8, Jan Cees de Groot 9, Annemiek M E Walenkamp 10, Myra E van Linde 11, Henk M W Verheul 12,13,✉ Brain Commun. 2024 Jul 30;6(4):fcae241. doi: 10.1093/braincomms/fcae241 Abstract Previously, the tyrosine kinase inhibitor sunitinib failed to show clinical benefit in patients with recurrent glioblastoma.

Irene Sbaraini Zernini, MD1; Chiara Faso, MD1; Carla Bittencourt Rynkowski, MD, PhD2,3 et al 2026년09월08일 JAMA Neurol. Published online: September 8, 2026. DOI:10.1001/jamanetwokropen.2026.32555 Abstract Importance Anemia is a prevalent condition among patients with traumatic brain injury (TBI); however, the optimal hemoglobin (Hb) threshold to initiate red blood cell transfusion (RBCT) is not well defined. Objective To assess which of 2 different Hb thresholds for guidi

Wolfgang Wick 1, Lisa-Marie Lanz 2, Antje Wick 3, Inga Harting 4, Susan Dettmer 2, Abigail K Suwala 5, Ralf Ketter 6, Ghazaleh Tabatabai 7 8, Corinna Seliger 3 9, Martin Glas 10, Michael C Burger 11, Marco Timmer 12, Florian A Ringel 13 14, Iris Mildenberger 15 16, Walter J Schulz-Schaeffer 17, Frank Winkler 3, Laila König 18, Christel Herold-Mende 19, Andreas Eisenmenger 2, Stefan M Pfister 20, Mirjam Renovanz 7 8 21, Martin Bendszus 4, Felix Sahm 22, Michael Platten 15 16,

Peter Alpkvist, MD1,2; Caroline Lindblad, MD, PhD1,2; Mikael Svensson, MD, PhD1,2 et alet al 2026년 8월24일 JAMA Neurol Published Online: August 24, 2026 DOI: 10.1001/jama.2026.2830 Abstract Importance Young survivors of aneurysmal subarachnoid hemorrhage (aSAH) risk de novo aneurysm formation, yet population-based lifetime estimates are lacking, and prior studies were limited by selection bias and short follow-up. Objectives To determine lifetime cumulative incidence, risk fa

Chen H, et al. et al Epub 2026 May 21 Stroke. 2026 Jul;57(7):1979-1990 DOI: 10.1161/STROKEAHA.126.055692 Abstract Background Unruptured intracranial aneurysms (UIAs) affect up to 5% of the population, and rupture can lead to devastating subarachnoid hemorrhage. GLP-1RAs (glucagon-like peptide-1 receptor agonists) have anti-inflammatory and vasculoprotective effects, but their impact on aneurysm stability and subarachnoid hemorrhage outcomes is unexplored. This study evalu

Patrick Y. Wen, MD1 ; Donald A. Berry, PhD2 ; Meredith B. Buxton, PhD3 ; Howard Colman, MD, PhD, FAAN4 ; John de Groot, MD5 ; Michael Lim, MD6 ; Ingo Mellinghoff, MD7 ; James R. Perry, MD, FRCPC, FAAN8 ; Michael Weller, MD9 ; Nicholas A. Blondin, MD10; Omar H. Butt, MD, PhD, MS11 ; Denise M. Damek, MD12; Macarena I. de la Fuente, MD13 ; Jan Drappatz, MD14; Erin Dunbar, MD15; Pierre Giglio, MD16; Emma Viktoria Hyddmark, PhD3 ; Fabio Iwamoto, MD17; Kurt A. Jaeckle, MD18 ; Lyndo

Christopher P. Kellner, MD1; Ansaar T. Rai, MD2; Hazem Shoirah, MD1 et alet al 2026년 6월 15일 JAMA Published Online: June 15, 2026 DOI: 10.1001/jama.2026.1542 Abstract Importance Middle meningeal artery embolization (MMAE) is a minimally invasive adjunctive treatment for chronic subdural hematoma (cSDH). The TRUFILL n-butyl cyanoacrylate (n-BCA) liquid embolic system is indicated for embolization of cerebral arteriovenous malformations for presurgical devascularization and may

Steven M. Greenberg, M.D., Ph.D 2026년 5월 6일 N Engl J Med 2026;394:1836-1845 DOI: 10.1056/NEJMra2411298 Summary Cerebral amyloid angiopathy is a major cause of hemorrhagic stroke, a frequent contributor to age-related cognitive impairment, and a key component in adverse responses to beta-amyloid (Aβ) immunotherapy. Defined by pathological deposition of Aβ in the small blood vessels of the brain, cerebral amyloid angiopathy is most often diagnosed on the basis of magnetic res

1. Alexander F. Haddad, MD1; Rithvik Ramesh, BA1; Jorge Armando Peña Agudelo, PhD2,3 JAMA Neurol Published Online: July 13, 2026 doi: 10.1001/jamaneurol.2026.2131 Abstract Importance Glioblastoma (GBM) remains a disease with high mortality despite treatment with maximal safe surgical resection, radiation, and temozolomide. Standard of care for GBM has remained unchanged for decades. Gene therapies using both viral and nonviral platforms have the potential to significantl

Yael Rosen-Lang, MPH1; Agathe Vrillon, MD, PhD2,3; Shlomit Pasternak, MSc1 et al 2026년 06월 29일 JAMA Published Online: June 29, 2026 DOI: 10.1001/jamaneurol.2026.2042 Abstract Importance Traumatic brain injury (TBI) is a risk factor for dementia and is known to impact levels of several Alzheimer disease (AD) blood biomarkers. The plasma phosphorylated tau 217 (p-tau217)/amyloid-β 42 (Aβ42) ratio has been reported to be 90% accurate for the detection of brain amyloid in civili

Craig S. Anderson, MBBS, PhD. et al. 2026년 4월 22일 N Engl J Med 2026;394:1571-1582 DOI: 10.1056/NEJMoa2515043 Abstract Background Blood-pressure reduction is the only proven treatment to prevent stroke due to intracerebral hemorrhage. Whether a single pill that combines three antihypertensive drugs at low doses, in addition to standard antihypertensive treatment, can lower blood pressure more than standard care alone and reduce the risk of recurrent stroke after intracereb

Haiqing Fan # 1, Yilin Luo # 1, Fang Gu 1, Bin Tian 1, Yongqin Xiong 1, Guipeng Wu 1, Xin Nie 1, Jing Yu 1, Juan Tong 1, Xin Liao 2 Affiliations Expand · PMID: 38486342 · PMCID: PMC10938723 · DOI: 10.1186/s40644-024-00682-y Abstract The specific genetic subtypes that gliomas exhibit result in variable clinical courses and the need to involve multidisciplinary teams of neurologists, epileptologists, neurooncologists and neurosurgeons. Currently, the dia

Wei Hu, M.D et al. 2026년5월 13일 N Engl J Med 2016;394:1894-1904. DOI: 10.1056/NEJMoa2514120 Abstract Background Endovascular thrombectomy for acute ischemic stroke due to medium-vessel occlusion has had varying results across trials. Whether thrombectomy improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits is unclear. Methods We conducted an open-label, randomized trial with blinded outcome assessment at 48 centers in China.

Andrea Soumbasis 1,2, Aito Ueno 3,4,5,6, David Elliott 7,8,9, Sanju Lama 10,11,12,13, Sarah Edwards 14, Yves P Starreveld 15,16, Yunyan Zhang 17,18,19,20, Paolo Federico 21,22,23,24, Garnette R Sutherland 25,26,27,28, Pierre LeVan 29,30,31,32,33, Candice C Poon 34,35,36,37,38,39,✉ Brain. 2025 Nov 28;149(5):1485–1497. doi: 10.1093/brain/awaf449 Abstract The discovery of the glymphatic system and meningeal lymphatic vessels revolutionized the understanding of brain waste cleara

David Fiorella, M.D., Ph.D. et al. 2024년 11월 20일 N Engl J Med 2025;392:855-864 DOI: 10.1056/NEJMoa2409845 Abstract Background Patients receiving standard treatment for chronic subdural hematoma have a high risk of treatment failure. The effect of adjunctive middle meningeal artery embolization on the risk of treatment failure in this population remains unknown. Methods We randomly assigned patients with symptomatic chronic subdural hematoma to undergo middle meningeal art

Kazufumi Ohmura 1,2 , Hiroyuki Tomita 1,3,* and Akira Hara 1 Biomedicines 2023, 11(10), 2731; https://doi.org/10.3390/biomedicines11102731 Submission received: 31 July 2023 / Revised: 29 September 2023 / Accepted: 6 October 2023 / Published: 9 October 2023 (This article belongs to the Special Issue Gliomas: Signaling Pathways, Molecular Mechanisms and Therapeutic Approaches) Abstract: Treating malignant glioma is challenging owing to its highly invasive potential in he

Jai Jai Shiva Shankar, MD, DM, MSc1,2,3; Susan Alcock, MN1; Nima Kashani, MD1et al 2026년04월30일 JAMA Neurol. Published online: April 30, 2026. DOI:10.1001/jamaneurol.2026.4910 Importance Chronic subdural hematomas commonly recur after surgical drainage. The effect of adjunctive embolization of the middle meningeal artery (EMMA) on recurrence risk remains unclear. Objective To evaluate whether EMMA as an adjunct to surgical drainage reduces chronic subdural hematoma recurrenc

Stefano Meletti, MD, PhD1,2; Aurelie Hanin, PhD3,4; Giada Giovannini, MD, PhD1 et al 2026년04월27일 JAMA Neurol. Published online: April 27, 2026. DOI:10.1001/jamaneurol.2026.0865 Abstract Importance Seizure-induced brain injury is central to the treatment urgency of new-onset refractory status epilepticus (NORSE). Identifying biomarkers that reflect ongoing neuronal damage could inform therapeutic timing and improve outcomes. Objective To quantify acute brain injury in pati

Pratibha Sharma , Ashley Aaroe, Jiyong Liang, and Vinay K. Puduvalli Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (P.S., A.A., J.L., V.K.P.) Corresponding Author: Vinay K. Puduvalli, MD, 1515 Holcombe Blvd, Unit 431, Houston, TX 77030, USA (vpuduval@mdanderson. org). Neuro-Oncology Advances 5(1), 1–16, 2023 | https://doi.org/10.1093/noajnl/vdad009 | Advance Access date 23 February 2023 Glioblastoma (GBM) tumor microenvir

Thomas Petutschnigg, MD1 ; Samuel Aschwanden1 ; Claire Descombes, MSc1 et al 2026년 04월13일 JAMA Neurol . Published online: April 13, 2026. Doi: 10.1001/jamaneurol.2026.0656 Abstract Importance Chronic subdural hematoma (cSDH) is among the most common neurosurgical disorders in older adults. Although short-term outcomes after surgery are favorable, long-term survival and health-related quality of life (HRQoL) remain poorly characterized. Objectives To evaluate long-t

Sérgio Brasil1*, Gustavo C. Patriota2 , Daniel Agustín Godoy3 , Jorge L. Paranhos4 , Andrés Mariano Rubiano5 and Wellingson S. Paiva Crit Care. 2025 Jun 5;29:229. doi: 10.1186/s13054-025-05476-7 Abstract The Monro-Kellie doctrine, introduced in the late 18th century, was a groundbreaking concept aimed at explaining the interactions between intracranial volume components. It has since become a cornerstone of brain physiology, now recognized as intracranial dynamics. Initial

Prescott, Hallie C. MD, MSc 1,2 ; Antonelli, Massimo MD 3,4 ; Alhazzani, Waleed MD, MSc, FRCPC 5,6,7 ; Møller, Morten Hylander MD, PhD 8,9 ; Alshamsi, Fayez MBBS 10 ; Azevedo, Luciano C. P. MD, PhD 11 ; Belley-Cote, Emilie MD, PhD 12,13,14 ; De Waele, Jan MD, PhD 15,16 ; Derde, Lennie MD, PhD 17,18 ; Dionne, Joanna C. MD, MSc, PhD, FRCPC 19,20 ; Evans, Laura MD 21 ; Gershengorn, Hayley B. MD 22,23 ; Hodgson, Carol L. PhD, PT, MPhils, PGDip(Crit Care) 24,25 ; Honarmand, Kimia

Emanuele Cerulli Irelli, MD, PhD1 ; Roberta Roberti, MD2 ; Maria Sole Borioni, MD1 et al 2026년 02월09일 JAMA Neurol . Published online: February 9, 2026 DOI:10.1001/jamaneurol.2025.5625 Abstract Importance Treatment decisions in drug-resistant focal epilepsy remain largely empirical, as direct comparative evidence among newer antiseizure medications (ASMs) is limited. Real-world data can complement randomized clinical trials by providing insights into long-term effectiv

Sohyon Lee , Tobias Weiss , Marcel Bühler , Julien Mena , Zuzanna Lottenbach , Rebekka Wegmann , Miaomiao Sun , Michel Bihl , Bartłomiej Augustynek , Sven P. Baumann , Sandra Goetze , Audrey van Drogen , Patrick G. A. Pedrioli , David Penton , Yasmin Festl , Alicia Buck , Daniel Kirschenbaum , Anna M. Zeitlberger , Marian C. Neidert , Flavio Vasella , Elisabeth J. Rushing , Bernd Wollscheid , Matthias A. Hediger , Michael Weller & Berend Snijder ...

Prof Geoffrey T Manley MD a , Prof Kristen Dams-O’Connor PhD b * , Michael L Alosco PhD c , Hibah O Awwad PhD d, Prof Jeffery J Bazarian MD e , Prof Peter Bragge BPhysio f , Prof John D Corrigan PhD g , Adele Doperalski PhD d, Prof Adam R Ferguson PhD a h , Prof Christine L Mac Donald PhD i , Prof David K Menon MD j , Prof Molly M McNett PhD k , Prof Joukje van der Naalt MD l , Prof Lindsay D Nelson PhD m , Dana Pisică MD n, Prof Noah D Silverberg PhD o...

Christopher J. Roberts, MD, PhD1,2 ; Amelia W. Maiga, MD, MPH3,4,5 ; Jason Barber, MS6 ; et al 2025년10월 10일 JAMA Netw Open Published Online: October 10, 2025 DOI: 10.1001/jamanetworkopen.2025.372271 Abstract Importance Exposure to extracranial (EC) surgery early after traumatic brain injury (TBI) is associated with cognitive risks. Objective To examine whether exposure to EC surgery during a TBI index admission is associated with worse outcomes at 1 year compared with n

Michael A. Williams, MD1 ; Mark G. Luciano, MD, PhD2 ; Jan Malm, MD, PhD3 et al 2026년02월06일 JAMA Neurol . Published online: February 2, 2026. Doi: 10.1001/jamaneurol.2025.5412 1965년 정상압 수두증(NPH)이 치료 가능한 치매의 한 형태 로 처음 기술된 이후, NPH에 대한 열광과 기대의 시대가 시작되었다. 당시에는 치매에 대한 치료가 거의 없었거나 상상조차 어려웠다. 곧 많은 치매 환자들이 방사성 동위원소 cisternography나 pneumo-encephalography를 기반으로 NPH로 진단받고 션트 수술을 받게 되었다. 초기에는 긍정적인 보고들이 쏟아졌지만, 이후 연구 결과에서는 점차 좋지 않은 결과들이 나타나기 시작했다. 1992년에 발표된 정상압 수두증에서 션트 수술의 이익이 위험

Shilpi Singh , Devanjan Dey , Debashis Barik , Iteeshree Mohapatra , Stefan Kim , Mayur Sharma , Sujata Prasad , Peize Wang , Amar Singh and Gatikrushna Singh Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patient survival. This review provides a comprehensive exploration of the molecular and genetic landscape of GBM, focusing on key oncogenic drivers, such as epidermal growth factor receptor (EGFR), platelet