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Lab of Neurologic recovery & Rejuvenation
Clinical Research News

Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations The Multicenter Arteriovenous Malformation Research Study (MARS)
Helen Kim, PhD1,2 ; Jeffrey Nelson, MS1 ; Charles E. McCulloch, PhD2 et al 2025년 10월6일 JAMA Neurol . Published online: October 6, 2025. Doi: 10.1001/jamaneurol.2025.3581 Abstract Importance Annual rates of first intracranial hemorrhage (ICH) from unruptured brain arteriovenous malformations (AVMs) are often quoted as 2% to 4% in clinical practice. Precise estimates and risk factors are unavailable to inform treatment decisions. Objectives To provide estimates of ra
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2일 전


The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective
Intensive Care Med, Volume 51, pages 2199-2212, (2025) Conference Repors and Expert Panel, Published: 03 November 2025 Doi: 10.1007/s00134-025-08186-4 Abstract Intensive care unit acquired weakness (ICUAW) is common in critically ill patients, contributing to substantial morbidity. Major trials and novel mechanistic findings published over the past years have advanced knowledge for the prevention and treatment of ICUAW. To streamline future research priorities, a multinat
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12월 16일


European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care
Intensive Care Med, Volume 51, pages 2213-2288, (2025) Conference Repors and Expert Panel, Published: 22 October 2025 Doi: 10.1007/s00134-025-08117-3 Abstract The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations (CoSTR) pubis
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12월 16일


Glioblastoma and Other Primary Brain Malignancies in Adults A Review
Lauren R. Schaff, MD 1,2 ; Ingo K. Mellinghoff, MD 1,2,3,4 JAMA Published Online: February 21, 2023 2023;329;(7):574-587. doi:10.1001/jama.2023.0023 Abstract Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the United States. The annual incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals and increases with age. Five-year survival is approximately 36%. Observations Approximately 49% of malignant brain
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12월 15일


Glioblastoma and brain connectivity: the need for a paradigm shift
Alessandro Salvalaggio, MD a,b,c ∙ Lorenzo Pini, PhD b ∙ Prof Alessandra Bertoldo, PhD c,d ∙ Prof Maurizio Corbetta, MD a,b,c,e maurizio.corbetta@unipd.it Publication History: Published July 2024 DOI: 10.1016/S1474-4422(24)00160-1 External Link Also available on ScienceDirect External Link Copyright: © 2024 Elsevier Ltd. All rights reserved. Summary Despite substantial advances in cancer treatment, for patients with glioblastoma prognosis remains bleak. The emer
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11월 24일
Neuropathy A Review
Michelle L. Mauermann, MD1 ; Nathan P. Staff, MD, PhD1 2025년 11월 17일 JAMA Published Online: November 17, 2025 DOI: 10.1001/jama.2025.19400 Abstract Importance Peripheral neuropathy, defined as damage to peripheral nerves, affects approximately 1% of adults worldwide. More than 200 causes of peripheral neuropathy exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair. Diabetes is the most common cause of neurop
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11월 18일


Burden of Central Nervous System Cancer in the United States, 1990-2021
GBD 2021 US CNS Cancer Collaborators 2025년 11월3일 JAMA Neurol . Published online: November 3, 2025. Doi: 10.1001/jamaneurol.2025.4286 Abstract Importance Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States. Objectives To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and S
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11월 11일


Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas A Randomized Clinical Trial
Chengcheng Guo, MD, PhD 1 ; Qunying Yang, MD, PhD 1 ; Pengfei Xu, MD, PhD 1 Meiling Deng, MD, PhD 2 ; Taipeng Jiang, MD, PhD 3 ; Linbo Cai, MD, PhD 4 ; Jibin Li, MD, PhD 5 ; Ke Sai, MD, PhD 1 ; Shaoyan Xi, MD, PhD 6 ; Hui Ouyang, MD, PhD 7 ; Mingfa Liu, MD, PhD 8 ; Xianming Li, MD, PhD 9,10 ; Zihuang Li, MD, PhD 9,10 ; Xiangrong Ni, MD, PhD 1 ; Xi Cao, BSN 1 ; Cong Li, MD, PhD 11,12 ; Shaoxiong Wu, MD, PhD 2 ; Xiaojing Du, MD, PhD 2 ; Jun Su, MD, PhD 13 ; Xi
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11월 3일


SOFA-2: 장기부전 평가의 새로운 시대
JAMA 2025. Ranzani et al.-30년 만의 전면 개정
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10월 31일
Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Otavio T. Ranzani, MD, MSc, PhD 1,2,3 ; Mervyn Singer, MD 4 ; Jorge I. F. Salluh, MD, PhD 5 et al 2025년 10월 29일 JAMA Published Online: October 29, 2025 DOI: 10.1001/jama.2025.20516 Abstract Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture current c
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10월 31일


Primary brain tumours in adults
Prof Martin J van den Bent, MD a m.vandenbent@erasmusmc.nl ∙ Marjolein Geurts, MD a ∙ Pim J French, PhD a ∙ ...
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10월 13일


Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria
The VasCog-2-WSO Criteria Consortium 2025년09월16일 JAMA Neurol . Published online: September 16, 2025. Doi: 10.1001/jamaneurol.2025.3242...
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9월 30일


A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus
Mark G. Luciano, M.D., Ph.D. et al. 2025년 9월 16일 N Engl J Med DOI: 10.1056/NEJMoa2503109 Abstract Background Idiopathic...
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9월 29일


White Matter Tract Density Index Prediction Model of Overall Survival in Glioblastoma
Alessandro Salvalaggio, MD, PhD 1,2 ; Lorenzo Pini, PhD 1,2 ; Matteo Gaiola, MD 1 et al JAMANeurol.2023;80(11):1222-1231.doi:10.1001/j...
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9월 22일


Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria
Michaël Chassé, MD, PhD1,2,3 ; Jai Jai Shiva Shankar, MD, MSc4,5 ; Dean A. Fergusson, PhD6,7 ; et al 2025년06월13일 JAMA Neurol...
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9월 10일


Depot Medroxyprogesterone Acetate and Risk of Meningioma in the US
Tianqi Xiao, MD1,2 ; Pranav Kumar, BA1,2 ; Mina Lobbous, MD, MSPH2,3 ; et al 2025년09월02일 JAMA Neurol . Published online: September 2,...
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9월 9일


Incidence and Prevalence of Frontotemporal DementiaA Systematic Review and Meta-Analysis
Daniele Urso, MD, MPH1,2 ; Stefano Giannoni-Luza, MD, MPH1 ; Carol Brayne, MD, MSc3 ; et al 2025년09월08일 JAMA Neurol . Published online:...
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9월 9일


Gadolinium-Enhanced Aneurysm Wall Imaging and Risk of Intracranial Aneurysm Growth or Rupture
Qingyuan Liu, MD1 ; Xin Nie, MD1 ; Mervyn D. I. Vergouwen, MD, PhD2 ; et al 2025년09월08일 JAMA Neurol . Published online: September 8,...
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9월 9일


Minimally Invasive Surgery vs Medical Management Alone for Intracerebral Hemorrhage The MIND Randomized Clinical Trial
Adam S. Arthur, MD, MPH1 ; Babak S. Jahromi, MD2 ; Paul S. Saphier, MD3,4 et al 2025년 9월 2일 JAMA Neurol . September 2, 2025 DOI:...
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9월 3일


Repeated blood–brain barrier opening with an implantable ultrasound device for delivery of albumin-bound paclitaxel in patients with recurrent glioblastoma: a phase 1 trial
Adam M Sonabend 1 , Andrew Gould 2 , Christina Amidei 2 , Rachel Ward 2 , Karyn A Schmidt 2 , Daniel Y Zhang 3 , ...
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9월 1일


Intracranial Hemorrhage in Patients With Stroke After Endovascular Treatment With or Without IV AlteplaseAn Individual Participant Data Meta-Analysis
Yu Zhou, MD1,2 ; Lei Zhang, MD1 ; Fabiano Cavalcante, MD, MSc3 ; et al 2025년 8월 11일 JAMA Neurol . August 11, 2025 DOI:...
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8월 12일


Short-course hypofractionated proton beam therapy, incorporating 18F-DOPA PET and contrast-enhanced MRI targeting, for patients aged 65 years and older with newly diagnosed glioblastoma: a single-arm
Prof Sujay Vora, MD a ∙ Deanna Pafundi, PhD d ∙ Molly Voss, BS e ∙ Matthew Buras, MS e ∙ Jonathan Ashman, MD a ∙ Prof Bernard...
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8월 11일


Augmented Enteral Protein During Critical IllnessThe TARGET Protein Randomized Clinical Trial
Matthew J. Summers, BSc, MDiet1,2 ; Lee-anne S. Chapple, PhD1,2,3,4 ; Amalia Karahalios, PhD5,6 ; et al 2025년 06월11일 JAMA. Published...
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7월 23일


GLP-1 Receptor Agonists in Idiopathic Intracranial Hypertension
Georgios S. Sioutas, MD1 ; William Mualem, MD1 ; John Reavey-Cantwell, MD, MBA, MS1 ; et al 2025년07월14일 JAMA Neurol . Published online:...
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7월 23일


Association of Maximal Extent of Resection of Contrast-Enhanced and Non–Contrast-Enhanced Tumor With Survival Within Molecular Subgroups of Patients With Newly Diagnosed Glioblastoma
Annette M. Molinaro, PhD; Shawn Hervey-Jumper, MD; Ramin A. Morshed, MD; Jacob Young, MD; Seunggu J. Han, MD; Pranathi Chunduru, MS;...
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7월 21일


Lomustine-temozolomide combination therapy versus standard temozolomide therapy in patients with newly diagnosed glioblastoma with methylated MGMT promoter (CeTeG/NOA–09)
: a randomised, open-label, phase 3 trial Ulrich Herrlinger*, Theophilos Tzaridis*, Frederic Mack, Joachim Peter Steinbach, Uwe...
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6월 30일
Risk of Poststroke Epilepsy Among Young Adults With Ischemic Stroke or Intracerebral Hemorrhage
Esmée Verburgt, MSc1 ; Lina Fellah, MSc1 ; Merel S. Ekker, MD, PhD1 ; et al 2025년04월 14일 JAMA Neurol . 2025;82(6):597-604 DOI:...
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6월 11일


Effect of Nivolumab vs Bevacizumab in Patients With Recurrent GlioblastomaThe CheckMate 143 Phase 3 Randomized Clinical Trial
David A. Reardon, MD1 ; Alba A. Brandes, MD2 ; Antonio Omuro, MD3 ; et al Paul Mulholland, PhD4 ; Michael Lim, MD5 ; Antje Wick, MD6...
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6월 9일


Long-Term Follow-Up of Extracranial-Intracranial Bypass Surgery for Symptomatic Cerebral Artery Occlusion
Yan Ma, MD1; Tao Wang, MD1; Wei Ni, MD2; et al 2025년 5월 22일 JAMA. Published online May 22, 2025. (Research Letter) DOI:...
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5월 23일


Residual Risk of Recurrent Stroke Despite Anticoagulation in Patients With Atrial FibrillationA Systematic Review and Meta-Analysis
John J. McCabe, PhD1,2,3; Yuen Cheung, MB1,2,3; Marianne Foley, MB1,2,3; et al 2025년 5월 21일 JAMA Neurol. Published online May 21, 2025....
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5월 23일


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