Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026

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Prescott, Hallie C. MD, MSc^1,2; Antonelli, Massimo MD^3,4; Alhazzani, Waleed MD, MSc, FRCPC^5,6,7; Møller, Morten Hylander MD, PhD^8,9; Alshamsi, Fayez MBBS¹⁰; Azevedo, Luciano C. P. MD, PhD¹¹; Belley-Cote, Emilie MD, PhD^12,13,14; De Waele, Jan MD, PhD^15,16; Derde, Lennie MD, PhD^17,18; Dionne, Joanna C. MD, MSc, PhD, FRCPC^19,20; Evans, Laura MD²¹; Gershengorn, Hayley B. MD^22,23; Hodgson, Carol L. PhD, PT, MPhils, PGDip(Crit Care)^24,25; Honarmand, Kimia MD, MSc, PhD^26,27; Kesecioglu, Jozef MD, PhD²⁸; McIntyre, Lauralyn MD^29,30; Mer, Mervyn MD, PhD³¹; Nunnally, Mark E. MD³²; Oczkowski, Simon J. W. MD^20,27; Rochwerg, Bram MD, MSc, FRCPC, FCCM, ATSF^20,27; Akinola, Olurotimi Olaolu MBBS, MMED³³; Akuamoah-Boateng, Kwame A. DNP, ACNP-BC, FCCM³⁴; Alberto, Laura BN, Esp.Ed., MEd, Com.Sc.(Dip), PhD^35,36; Angus, Derek C. MD³⁷; Arabi, Yaseen M. MD³⁸; Azoulay, Elie MD³⁹; Cecconi, Maurizio MD^40,41; Convocar, Pauline F. MD, MCHM^42,43,44; De Pascale, Gennaro MD^3,4; Doi, Kent MD, PhD⁴⁵; Du, Bin MD⁴⁶; Egi, Moritoki MD⁴⁷; Elie-Turenne, Marie-Carmelle MD^48,49; Ferrer, Ricard MD, PhD^50,51; Fox-Robichaud, Alison MD^52,53; French, Craig MBBS^24,54; Freund, Yonathan MD, PhD^55,56; Gong, Michelle Ng MD, MS⁵⁷; Hale, Caleb P. MD⁵⁸; Hammond, Naomi E. RN, BN, MN (Crit.Care), MPH, PhD^59,60; Hashmi, Madiha MD, FFARCSI⁶¹; Heunks, Leo MD, PhD⁶²; Iwashyna, Theodore J. MD, PhD^63,64; Jacob, Shevin T. MD, MPH^65,66; Klompas, Michael MD, MPH^67,68; Kwizera, Arthur MD⁶⁹; Leeies, Murdoch MD^70,71; Lejnieks, Joanna D. RN⁷²; Levy, Mitchell M. MD⁷³; Machado, Flavia R. MD, PhD⁷⁴; Maia, Marcelo O. MD^75,76,77; Masur, Henry MD⁷⁸; Maves, Ryan C. MD^79,80; McGloughlin, Steven MD^25,81; McPeake, Joanne PhD, MSc, BN (Hons), RGN⁸²; Mohr, Nicholas M. MD, MS^83,84,85; Myatra, Sheila Nainan MD⁸⁶; Ostermann, Marlies MD, PhD^87,88; Peake, Sandra L. MD, PhD, FCICM^89,90,91; Pletz, Mathias W. MD^92,93; Roberts, Jason A. PhD^94,95,96; Rosa, Regis G. MD^97,98,99; Sawyer, Robert G. MD¹⁰⁰; Schorr, Christa A. RN, DNP^101,102; Simpson, Steven Q. MD¹⁰³; Weng, Li MD¹⁰⁴; Wiersinga, W. Joost MD, PhD, MBA^105,106,107; Rhodes, Andrew MBBS, MD¹⁰⁸; Coopersmith, Craig M. MD¹⁰⁹

Critical Care Medicine ():10.1097/CCM.0000000000007075, March 23, 2026. | DOI: 10.1097/CCM.0000000000007075

Sepsis, life-threatening acute organ dysfunction due to infection (¹), is a global health priority (^2,3) with approximately 49 million cases and 13 million sepsis-related deaths each year (^4–6). Beyond being acutely deadly, sepsis contributes to new and worsened physical, cognitive, and mental health problems in many survivors (^7,8). Early identification and treatment are critical to improving outcomes.

The Surviving Sepsis Campaign (SSC) guidelines are intended to support clinicians caring for adult patients with sepsis, focusing on management in the hospital, the immediate prehospital setting, and the immediate post-hospital setting. These guidelines incorporate principles of antimicrobial stewardship through responsible antimicrobial use, proper diagnostic strategies, and de-escalation of antimicrobial therapy. The recommendations reflect evidence-based best practice, distilling a large body of research into actionable recommendations. They empower individuals and health systems to make informed choices about care and support improvements in management and outcomes of sepsis (Table 1).

· 패혈증은 감염으로 인한 생명 위협적 장기 기능 장애이며 전 세계적으로 매우 중요한 질환

· 매년 약 4,900만 명 발생 / 1,300만 명 사망

· 생존자에서도 신체·인지·정신적 후유증 흔함

· 조기 진단과 치료가 예후 개선의 핵심

· SSC 가이드라인은

→ 병원 전, 입원 중, 퇴원 직후까지 전체 치료 과정을 포괄

→ 항생제 적정 사용 + 진단 + 감량 전략 포함

→ 근거 기반으로 정리된 실제 적용 가능한 치료 지침

→ 임상 결정 및 치료 결과 개선에 도움