

Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma
1.논문 제목: Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma 2.저자명: Xinyu He, Yubing Zhou, Wenjing Chen, Xiaokun Zhao, Lina Duan, Hao Zhou, Mingzhu Li, Yin Yu, Jimin Zhao, Yaping Guo, Huihui Gu, Yanan Jiang, Zigang Dong, Kangdong Liu 3.Publish: 25 February 2023 4.DOI: https://doi.org/10.1038/s41388-023-02636-3 5.Abstract: Targeted therapy attempts are needed to enhance esophageal squamous c
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23시간 전4분 분량


ARE-PROTACs Enable Co-degradation of an Nrf2–MafG Heterodimer
Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z. ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer. J Med Chem. 2023 May 11;66(9):6070-6081. doi: 10.1021/acs.jmedchem.2c01909. Proteolysis-targeting chimera (PROTAC) technology has emerged as a potential strategy to degrade “undruggable” proteins in recent years. Nrf2, an aberrantly activated transcription factor in cancer, is generally considered undruggable as lacking active sites or allosteric pockets. Here, we
한울 전
7월 21일3분 분량


Recent Advances and Future Prospects in Gene Delivery Platforms for Glioblastoma : A Review
1. Alexander F. Haddad, MD1; Rithvik Ramesh, BA1; Jorge Armando Peña Agudelo, PhD2,3 JAMA Neurol Published Online: July 13, 2026 doi: 10.1001/jamaneurol.2026.2131 Abstract Importance Glioblastoma (GBM) remains a disease with high mortality despite treatment with maximal safe surgical resection, radiation, and temozolomide. Standard of care for GBM has remained unchanged for decades. Gene therapies using both viral and nonviral platforms have the potential to significantl
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7월 20일2분 분량


Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers
Yael Rosen-Lang, MPH1; Agathe Vrillon, MD, PhD2,3; Shlomit Pasternak, MSc1 et al 2026년 06월 29일 JAMA Published Online: June 29, 2026 DOI: 10.1001/jamaneurol.2026.2042 Abstract Importance Traumatic brain injury (TBI) is a risk factor for dementia and is known to impact levels of several Alzheimer disease (AD) blood biomarkers. The plasma phosphorylated tau 217 (p-tau217)/amyloid-β 42 (Aβ42) ratio has been reported to be 90% accurate for the detection of brain amyloid in civili
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7월 14일4분 분량


Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma
1.논문 제목: Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma 2.저자명: Songlei Zhou, Yukun Huang, YuChen, Yipu Liu, Laozhi Xie, YangYou, Shiqiang Tong, Jianpei Xu, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, Hongzhuan Chen & Jun Chen 3. 출처 및 게재 (발행일): Nature communications, 26 January 2023 4. DOI: https://doi.org/10.1038/s41467-023-35957-8 5. Abstract: The limited benefits of immunotherapy against glioblastoma (GBM) is
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7월 13일3분 분량


NRF2 promotes ferroptosis sensitivity in temozolomide-resistant glioblastoma cells through MRP1/ABCC1 regulation
1.논문 제목: NRF2 promotes ferroptosis sensitivity in temozolomide-resistant glioblastoma cells through MRP1/ABCC1 regulation 2.저자명: Isabela de Souza, Luiza K. S. Moreira, Camila B. Gomes, Marina T. Andrade, Bruna C. Carvalho, Mariana M. Silva, Bruno F. M. M. Pereira, Mariana T. Latancia, Daniela Menck, Marcelo Lancellotti, Luiz R. G. Gomes, C. R. R. Rocha 3.Publish: July 1, 2022 4.DOI: 10.1038/s41419-022-05044-9 5.Abstract: Glioblastoma frequently develops resistance to temozolo
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7월 13일3분 분량


Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery
1.논문 제목: Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery 2.저자명: Lingling Shen, Jian Fang, Lulu Liu, Fei Yang, Jeremy L. Jenkins, Peter S. Kutchukian, He Wang 3.Publish: 21 March 2024 4.DOI: https://doi.org/10.1186/s13321-024-00829-w 5.Abstract: We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit-finding activity in the drug discovery process.
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7월 9일3분 분량


Microglial SRGN aggravates neuroinflammation after ischemic stroke via interacting with CD44
1.논문 제목: Microglial SRGN aggravates neuroinflammation after ischemic stroke via interacting with CD44 2.저자명: Yi Qian, Lixuan Yang, Jian Chen, Na Zhang, Yuting Gu, Xiaofei Bao, Shuxuan Xie, Hai Yu, Yanchun Chen, Chao Zhao, Yun Xu 3.출처 및 게제일: Journal of Neuroinflammation, 29 January 2024 4.DOI: http://dio.org/10.1186/s12974-024-03026-6. 5.Abstract: Ischemic stroke triggers severe neuroinflammation driven largely by activated microglia. This study investigated the role of Sergly
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6월 30일2분 분량


Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy
1.논문 제목: Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy 2.저자명: Haoge Zhang, JiaMiao, LinGao, Xuhong Yang, Zhengcheng Yun, LeiDong, Wanqing Cheng, Yuqi Wang, Hui Yang, Ying Zhou, Yini Zhu & Jinbing Xie 3.출처 및 게제일: Nature communications, 11 April 2026 4.DOI: https://doi.org/10.1038/s41467-026-71646-y 5.Abstract: Bispecific immune cell engagers, particularly bispecific T-cell engagers, show limited effic
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6월 29일3분 분량


Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage
Craig S. Anderson, MBBS, PhD. et al. 2026년 4월 22일 N Engl J Med 2026;394:1571-1582 DOI: 10.1056/NEJMoa2515043 Abstract Background Blood-pressure reduction is the only proven treatment to prevent stroke due to intracerebral hemorrhage. Whether a single pill that combines three antihypertensive drugs at low doses, in addition to standard antihypertensive treatment, can lower blood pressure more than standard care alone and reduce the risk of recurrent stroke after intracereb
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6월 29일3분 분량
Artificial intelligence-based MRI radiomics and radiogenomics in glioma
Haiqing Fan # 1, Yilin Luo # 1, Fang Gu 1, Bin Tian 1, Yongqin Xiong 1, Guipeng Wu 1, Xin Nie 1, Jing Yu 1, Juan Tong 1, Xin Liao 2 Affiliations Expand · PMID: 38486342 · PMCID: PMC10938723 · DOI: 10.1186/s40644-024-00682-y Abstract The specific genetic subtypes that gliomas exhibit result in variable clinical courses and the need to involve multidisciplinary teams of neurologists, epileptologists, neurooncologists and neurosurgeons. Currently, the dia
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6월 22일2분 분량


Activity cliff-aware reinforcement learning for de novo drug design
1.논문 제목: Activity cliff-aware reinforcement learning for de novo drug design 2.저자명: Xiuyuan Hu, Guoqing Liu, Yang Zhao, Hao Zhang 3.Publish: 21 April 2025 4.DOI: https://doi.org/10.1186/s13321-025-01006-3 5.Abstract: The integration of artificial intelligence (AI) in drug discovery offers promising opportunities to streamline and enhance the traditional drug development process. One core challenge in de novo molecular design is modeling complex structure-activity relationship
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6월 22일4분 분량


The membrane receptor CD44: novel insights into metabolism
Weng X, Maxwell-Warburton S, Hasib A, Ma L, Kang L. The membrane receptor CD44: novel insights into metabolism. Trends Endocrinol Metab. 2022 May;33(5):318-332. doi: 10.1016/j.tem.2022.02.002. Epub 2022 Mar 4. PMID: 35249813. 초록 CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its essential role in physiological activities in normal cells and pathological activities in cancer cells, such as cell proliferation, adhesion, and migration; angio
한울 전
6월 17일3분 분량


Endovascular Treatment of Medium-Vessel-Occlusion Strokes
Wei Hu, M.D et al. 2026년5월 13일 N Engl J Med 2016;394:1894-1904. DOI: 10.1056/NEJMoa2514120 Abstract Background Endovascular thrombectomy for acute ischemic stroke due to medium-vessel occlusion has had varying results across trials. Whether thrombectomy improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits is unclear. Methods We conducted an open-label, randomized trial with blinded outcome assessment at 48 centers in China.
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6월 15일3분 분량


Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mousemodels of glioblastoma.
1. 논문 제목: Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma. 2. 저자명: JongHoon Ha, Yifan Wang, YifanMa, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L. Edwards, Mengyu Chang, Yen-Tzu Chang, XiaotianWang, MauriceDufilho, Michelle Najarro Torres, Shannon McCabe, Weiye Deng, Adam J. Grippin, Jeffrey S. Weinberg, ShaanM. Raza, Franco DeMonte, Ian E. McCutcheon, Sujit Prabhu, Sherise D. Ferguson, Chibawanye I. Ene, Kadir Akdem
김소영
6월 8일3분 분량


Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition
1.논문 제목: Activation of the NRF2 antioxidant program sensitizes tumors to G6PD inhibition 2.저자명: Hongyu Ding, Zihong Chen, Katherine Wu, Shih Ming Huang, Warren L. Wu, Sarah E. LeBoeuf, Ray G. Pillai, Joshua D. Rabinowitz, Thales Papagiannakopoulos. 3.발행일: Science Advances,17 Nov 2021 4.DOI: 10.1126/sciadv.abk1023 5.Abstract: The KEAP1/NRF2 signaling pathway is frequently activated in cancer and promotes antioxidant defense and metabolic adaptation. To identify metabolic vulne
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6월 8일3분 분량


CSearch: chemical space search via virtual synthesis and global optimization
1.논문 제목: CSearch: chemical space search via virtual synthesis and global optimization 2.저자명: Hakjean Kim, Seongok Ryu, Nuri Jung, Jinsol Yang, Chaok Seok 3.Publish: 05 December 2024 4.DOI : https://doi.org/10.1186/s13321-024-00936-8 5.Abstract: The two key components of computational molecular design are virtually generating molecules and predicting the properties of these generated molecules. This study focuses on an effective method for molecular generation through virtual
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6월 1일3분 분량


The glymphatic system and glioblastoma
Andrea Soumbasis 1,2, Aito Ueno 3,4,5,6, David Elliott 7,8,9, Sanju Lama 10,11,12,13, Sarah Edwards 14, Yves P Starreveld 15,16, Yunyan Zhang 17,18,19,20, Paolo Federico 21,22,23,24, Garnette R Sutherland 25,26,27,28, Pierre LeVan 29,30,31,32,33, Candice C Poon 34,35,36,37,38,39,✉ Brain. 2025 Nov 28;149(5):1485–1497. doi: 10.1093/brain/awaf449 Abstract The discovery of the glymphatic system and meningeal lymphatic vessels revolutionized the understanding of brain waste cleara
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6월 1일2분 분량


Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma
David Fiorella, M.D., Ph.D. et al. 2024년 11월 20일 N Engl J Med 2025;392:855-864 DOI: 10.1056/NEJMoa2409845 Abstract Background Patients receiving standard treatment for chronic subdural hematoma have a high risk of treatment failure. The effect of adjunctive middle meningeal artery embolization on the risk of treatment failure in this population remains unknown. Methods We randomly assigned patients with symptomatic chronic subdural hematoma to undergo middle meningeal art
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5월 27일3분 분량


Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cellsand restores anti-tumor immunity.
1. 논문 제목: Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity. 2. 저자명: Yonghua Li, Min Sheng, Weijie Li, Simin Liu, Botao Wang, Bing Liu, Mei Luo, Xiao Zhou, Qiaoxi Xia, Shihong Hong, Ziyuan Zheng, Shi-Yuan Cheng, Xiaobing Jiang, JunjunLi &Tianzhi Huang 3. 출처 및 게재 (발행일): Nature communications, 13 December 2025 4. DOI: https://doi.org/10.1038/s41467-025-67119-3 5. Abstract: Chaperone-mediated autophagy (CMA
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5월 19일3분 분량




