

Targeting TRIM25 as a therapeutic strategy to enhance ferroptosis in glioblastoma cells
1.논문 제목: Targeting TRIM25 as a therapeutic strategy to enhance ferroptosis in glioblastoma cells 2.저자명: Maorong Zhu, Yuxin Wu, Huihui Ou, Xiao Liu, Yawen Wang, Xiaolin Liu, Cheng Zou, Guangzhao Yang, Mingrui Du, Duo Yu, Dan Zheng, Lei He, Kuo Zhang, Wangqian Zhang, Shuning Wang, Haozhe Qin, Qiang Hao, Yalong He, Wei Lin, Yingqi Zhang, Jintao Gu, Meng Li, Weidong Qin, Zhengcong Cao 3.Publish: Journal of Nanobiotechnology, 2026 4.DOI: https://doi.org/10.1186/s12951-025-03908-8
김영혜
1일 전2분 분량


ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries
1.논문 제목: ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries 2.저자명: Kyle Swanson, Parker Walther, Jeremy Leitz, Souhrid Mukherjee, Joseph C. Wu, Rabindra V. Shivnaraine, James Zou 3.Publish: 2024 Jul 01 4.DOI: 10.1093/bioinformatics/btae416 5.Abstract: The emergence of large chemical repositories and combinatorial chemical spaces, coupled with high-throughput docking and generative AI, have greatly expanded the chemical diversity of sm
임지현
11월 3일3분 분량


Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis
1.논문 제목: Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis 2.저자명: Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang 3.Publish: Advanced Science, 2026 4.DOI: https://doi.org/10.1002/advs.202521236 5.Abstract: Glioblastoma (GBM) is a highly aggressive brain tumor with limited therapeutic options. This study developed
지우 이
11월 2일2분 분량


Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial
Stephen J Bagley 1 2 3, Arati S Desai 4 5 6, Joseph A Fraietta 7 8, Dana Silverbush 9, Daniel Chafamo 6, Nelson F Freeburg 9, Gayathri Konanur Gopikrishna 9, Andrew J Rech 7 10, Ali Nabavizadeh 11, Linda J Bagley 6 11, Jungmin Park 5 6 7, Danuta Jarocha 7, Rene Martins 7, Nicolas Sarmiento 7, Eileen Maloney 5 6, Lester Lledo 7, Carly Stein 7, Amy Marshall 7, Rachel M Leskowitz 7, Julie K Jadlowsky 7, Shane Mackey 7, Shannon Christensen 7, Bike Su Oner 7, Gabriela Plesa 7, And
소영 정
11월 2일4분 분량


Comparison of two automated pupillometry indices in patients with acute brain injury: the prospective multicentre LYNX cohort study
Pierre Bouzat 1,5,✉, Aaron Blandino-Ortiz 2, Antoine Vilotitch 3 et al 2026년09월28일 Crit Care.September 28, 2026. DOI:10.1186/s13054-026-06360-8 Abstract Background Automated pupillometry quantifies the pupillary light reflex in acute brain injury. The neurological pupil index (NPi) is the established composite index and carries prognostic value. A second index from a different device, the quantitative pupil index (QPi), has recently become available, but whether it conveys
이정희
10월 27일4분 분량


A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression
Nathchar Naowarojna, Xin Gu, Zijian Pan, Tao Peng, Yikai Wang , Yilong Zou, 2026, Cell 189, 1–15 https://www.cell.com/cell/fulltext/S0092-8674(26)01200-6 초록 Ferroptosis is implicated in multiple human diseases, but the lack of bioavailable inducers has limited its physiological study and therapeutic translation. Here, we report KY0418, a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) featuring an isourea warhead, with high plasma stability and broad tissue
한울 전
10월 25일4분 분량


Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes
1.논문 제목 : Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes 2.저자명: Wenyan Hao, Nan Sun, Yueyue Fan, Mengyu Chen, Qianqian Liu, Meiyan Yang, Yang Yang, Chunsheng Gao, 3.Publish: 22 May 2024 4.DOI: https://doi.org/10.1021/acsami.4c04604 5.Abstract: Glioblastoma is a highly aggressive brain tumor that remains difficult to treat, highlighting the need for effective drug d
지우 이
10월 19일3분 분량


The STELLAR trial: a phase II/III randomized trial of high-dose, intermittent sunitinib in patients with recurrent glioblastoma
Jorien B E Janssen 1,#, Cyrillo G Brahm 2,#, Chantal M L Driessen 3, Janine Nuver 4, Mariette Labots 5, Mathilde C M Kouwenhoven 6, Esther Sanchez Aliaga 7, Roelien H Enting 8, Jan Cees de Groot 9, Annemiek M E Walenkamp 10, Myra E van Linde 11, Henk M W Verheul 12,13,✉ Brain Commun. 2024 Jul 30;6(4):fcae241. doi: 10.1093/braincomms/fcae241 Abstract Previously, the tyrosine kinase inhibitor sunitinib failed to show clinical benefit in patients with recurrent glioblastoma.
소영 정
10월 13일2분 분량


Degrading GPX4 via Biomimetic Nanoparticle-Mediated InSitu Synthesis of Deep-Learning-Designed Binder-DegronChimeras for Prostate Cancer Therapy
Si-Han Zhang, Ye An, Na Zeng, Mei-Cheng Liu, Jian-Xuan Sun, Xi Gong, Jin-Zhou Xu, Shao-Gang Wang, Qi-Dong Xia Adv Sci (Weinh) . 2026 Sep 27:e77932 Abstract Glutathione peroxidase 4 (GPX4) is a central guardian against ferroptosis and a critical therapeutic target for castration-resistant prostate cancer (CRPC). However, traditional GPX4 inhibitors are often limited by irreversible covalent binding and systemic toxicity. Here, we utilized the deep learning algorithm Bindcraft
한울 전
10월 12일4분 분량


Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy
1.논문 제목: Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy. 2.저자명: Muhammad Umer Khan, Maha Munir, Hina Manzoor, Ismail Hamad, Tahir Ali Chohan, Badriyah S Alotaibi 3.Publish: 13 February 2026 4.DOI: https://doi.org/10.1038/s41598-026-39629-7 5.Abstract: Glioblastoma multiform (GBM) is the most deadly type of primary CNS tumor and is linked to dysregulation of the CDK4/6 pathway, poor prognosis, and high rate of post-surgical recurr
임지현
10월 12일4분 분량


Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury A Secondary Analysis of the TRAIN Trial
Irene Sbaraini Zernini, MD1; Chiara Faso, MD1; Carla Bittencourt Rynkowski, MD, PhD2,3 et al 2026년09월08일 JAMA Neurol. Published online: September 8, 2026. DOI:10.1001/jamanetwokropen.2026.32555 Abstract Importance Anemia is a prevalent condition among patients with traumatic brain injury (TBI); however, the optimal hemoglobin (Hb) threshold to initiate red blood cell transfusion (RBCT) is not well defined. Objective To assess which of 2 different Hb thresholds for guidi
이정희
10월 7일4분 분량


Ferroptosis resistance-related TEP1 as a novel prognostic biomarker involved in immune cell infiltration and tumour progression in glioblastoma
1. 논문 제목: Ferroptosis resistance-related TEP1 as a novel prognostic biomarker involved in immune cell infiltration and tumour progression in glioblastoma 2. 저자명: Kunxiang Chen, Chengzong Zhong, Yiqing Wang, Tao Liu, Huan Chen, Ruizhi Wu, Guanping Qiu, Siqi Zheng, Yong Gao, Yuean Ping, Qiang Zhou, Yuntao Lu and Hong Li 3. 출처 및 게재 (발행일): Cancer Cell International, 3 December 2025 4. DOI: https://doi.org/10.1186/s12935-025-04114-0 5. Abstract: 5-1 Background: TEP1 is a ribonucl
김소영
9월 28일3분 분량


Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme
1.논문 제목: Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme 2.저자명: Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Alfredo Quinones-Hinojosa, Debabrata Mukhopadhyay 3.Publish: Communications
지우 이
9월 28일3분 분량


REINVENT 4: Modern AI-driven generative molecule design
1.논문 제목: REINVENT 4: Modern AI-driven generative molecule design 2.저자명: Hannes H. Loeffler, Jiazhen He, Alessandro Tibo, Jon Paul Janet, Alexey Voronov, Lewis H. Mervin, Ola Engkvist 3.Publiush: 21 February 2024 4.DOI: https://doi.org/10.1186/s13321-024-00812-5 5.Abstract: REINVENT 4 is a modern open-source generative AI framework for the design of small molecules. The software utilizes recurrent neural networks and transformer architectures to drive molecule generation. Thes
임지현
9월 21일3분 분량


Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial
Wolfgang Wick 1, Lisa-Marie Lanz 2, Antje Wick 3, Inga Harting 4, Susan Dettmer 2, Abigail K Suwala 5, Ralf Ketter 6, Ghazaleh Tabatabai 7 8, Corinna Seliger 3 9, Martin Glas 10, Michael C Burger 11, Marco Timmer 12, Florian A Ringel 13 14, Iris Mildenberger 15 16, Walter J Schulz-Schaeffer 17, Frank Winkler 3, Laila König 18, Christel Herold-Mende 19, Andreas Eisenmenger 2, Stefan M Pfister 20, Mirjam Renovanz 7 8 21, Martin Bendszus 4, Felix Sahm 22, Michael Platten 15 16,
소영 정
9월 15일3분 분량


Lifelong De Novo Aneurysm Risk After Aneurysmal Subarachnoid Hemorrhage in Young Survivors
Peter Alpkvist, MD1,2; Caroline Lindblad, MD, PhD1,2; Mikael Svensson, MD, PhD1,2 et alet al 2026년 8월24일 JAMA Neurol Published Online: August 24, 2026 DOI: 10.1001/jama.2026.2830 Abstract Importance Young survivors of aneurysmal subarachnoid hemorrhage (aSAH) risk de novo aneurysm formation, yet population-based lifetime estimates are lacking, and prior studies were limited by selection bias and short follow-up. Objectives To determine lifetime cumulative incidence, risk fa
이정희
9월 8일4분 분량


Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
1. 논문 제목: Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect. 2. 저자명: Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng and Aimin Li 3. 출처 및 게재 (발행일): Journal of Nanobiotechnology, 23 December 2021 4. DOI: https://doi.org/10.1186/s12951-021-01180-0 5. Abstract: The integrin αvβ3 receptor and Lactoferrin receptor (LfR) are over-expressed in both cerebral microvascular
김소영
9월 8일3분 분량


Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy
1.논문 제목: Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy 2.저자명: Boyan Li, Xin Chen, J. Dong, S. Zhang, W. Qin, R. Zhang, Z. Peng, S. Zhang, Q. Guo, Y. Qin, W. Wang, L. Deng, S. Nie, Y. Sun, H. Xu, H. Li, G. Liu 3.Publish: Advanced Science, 2022 4.DOI: 10.1002/advs.202105451 5.Abstract: GBM은 높은 악성도와 BBB로 인해 약물이 종양에 효과적으로 전달되기 어렵다. 또한 페롭토시스를 이용한 치료에서도 암세포가 여러 방어기전을 통해 페롭토시스를 회피할 수 있다. 본 연구에
지우 이
9월 8일3분 분량


Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer
1.논문 제목: Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer 2.저자명: Congjun Xu, Zhanghong Xiao, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, Chunshun Zhao 3.Publish: September 10, 2021 4.DOI: https://doi.org/10.1021/acs.jmedchem.1c00569 5.Abstract: Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptos
임지현
9월 1일3분 분량


GLP-1 Receptor Agonist Use Is Associated With Lower Risk of Intracranial Aneurysm Rupture and Rupture Severity
Chen H, et al. et al Epub 2026 May 21 Stroke. 2026 Jul;57(7):1979-1990 DOI: 10.1161/STROKEAHA.126.055692 Abstract Background Unruptured intracranial aneurysms (UIAs) affect up to 5% of the population, and rupture can lead to devastating subarachnoid hemorrhage. GLP-1RAs (glucagon-like peptide-1 receptor agonists) have anti-inflammatory and vasculoprotective effects, but their impact on aneurysm stability and subarachnoid hemorrhage outcomes is unexplored. This study evalu
이정희
8월 24일3분 분량




