

Small molecule drug discovery for glioblastoma treatment based on bioinformatics and cheminformatics approaches
1.논문 제목: Small molecule drug discovery for glioblastoma treatment based on bioinformatics and cheminformatics approaches 2.저자명: Liya Feng, Sha Zhu, Jian Ma, Jing Huang, Xiaoyan Hou, Qian Qiu, Tingting Zhang, Meixia Wan, Juan Li 3.Publish: 12 April 2024 4.DOI: https://doi.org/10.3389/fphar.2024.1389440 5.Abstract: Background: Glioblastoma (GBM) is a common and highly aggressive brain tumor with a poor prognosis for patients. It is urgently needed to identify potential small
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14시간 전5분 분량


Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery The EMMA-Can Randomized Clinical Trial
Jai Jai Shiva Shankar, MD, DM, MSc1,2,3; Susan Alcock, MN1; Nima Kashani, MD1et al 2026년04월30일 JAMA Neurol. Published online: April 30, 2026. DOI:10.1001/jamaneurol.2026.4910 Importance Chronic subdural hematomas commonly recur after surgical drainage. The effect of adjunctive embolization of the middle meningeal artery (EMMA) on recurrence risk remains unclear. Objective To evaluate whether EMMA as an adjunct to surgical drainage reduces chronic subdural hematoma recurrenc
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5일 전3분 분량


Nanoparticles hijack calvarial immune cells for CNS drug delivery and stroke therapy
Cell, Vol. 189, pp. 1341–1355, March 5, 2026 Gao X, Liu X, Wang N et al. https://www.cell.com/cell/fulltext/S0092-8674%2825%2901421-7#fig1 초록 The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells using drug-loaded nanoparticles (NPs) and leveraged their unique migration mechanism through skull-
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5월 5일4분 분량


Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus
Stefano Meletti, MD, PhD1,2; Aurelie Hanin, PhD3,4; Giada Giovannini, MD, PhD1 et al 2026년04월27일 JAMA Neurol. Published online: April 27, 2026. DOI:10.1001/jamaneurol.2026.0865 Abstract Importance Seizure-induced brain injury is central to the treatment urgency of new-onset refractory status epilepticus (NORSE). Identifying biomarkers that reflect ongoing neuronal damage could inform therapeutic timing and improve outcomes. Objective To quantify acute brain injury in pati
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4월 28일4분 분량


Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities.
1.논문제목: Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities. 2.저자명: Jun Lin, Chunpeng Chen, Shouzhen Li, Liu Chen, Minghao Fang, Shuqi Fu, Kaixing Chen, Hao Xu, Fenghuan Zhang, Rirui Wang, Chen Jiang, Meifang Tang, Zitian Liu, Shuyan Wang, Ke Liu, Chaoshi Niu, Bin Li, Xu Liu, Chuandong Cheng, Ai-Hui Tang & Kun Qu 3.발행일: Nature neuroscience, 16 April 2026 4.DOI: https://doi.org/10.1038/s41593-026-02265-5
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4월 27일3분 분량


Liposomal Nanomaterials: A Rising Star in Glioma Treatment
1.논문 제목: Liposomal Nanomaterials: A Rising Star in Glioma Treatment 2.저자명: Yu Gan, Yingying Yu, Huizhe Xu, Haozhe Piao. 3.Publish: 2024 July 4.DOI: 10.2147/IJN.S470478 5.Abstract: Glioma remains one of the most aggressive primary tumors of the central nervous system, with limited therapeutic efficacy due to the presence of the blood–brain barrier (BBB). Conventional treatments such as surgery, radiotherapy, and chemotherapy fail to significantly improve patient survival. Rece
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4월 27일3분 분량


Tumor microenvironment in glioblastoma: Current and emerging concepts
Pratibha Sharma , Ashley Aaroe, Jiyong Liang, and Vinay K. Puduvalli Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (P.S., A.A., J.L., V.K.P.) Corresponding Author: Vinay K. Puduvalli, MD, 1515 Holcombe Blvd, Unit 431, Houston, TX 77030, USA (vpuduval@mdanderson. org). Neuro-Oncology Advances 5(1), 1–16, 2023 | https://doi.org/10.1093/noajnl/vdad009 | Advance Access date 23 February 2023 Glioblastoma (GBM) tumor microenvir
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4월 27일2분 분량


Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma
1.논문제목 : Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma 2.저자명: Susan Costantini, Isabella Romeo, Giulia Fanelli, Maria Serena Roca, Gianmarco Gualtieri, Palmina Bagnara, Andrea Polo, Elena Di Gennaro, Francesco Ortuso, Stefano Alcaro, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi, Claudia Abbruzzese 3.Pub lish: 2025 Dec 8 4.DO I : 10.1186/s12967-025-07444-9 5.Abstract 5-1 Background: Glioblastoma (GBM
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4월 20일4분 분량


Long-Term Mortality, Cognition, and Quality of Life After Chronic Subdural Hematoma Surgery
Thomas Petutschnigg, MD1 ; Samuel Aschwanden1 ; Claire Descombes, MSc1 et al 2026년 04월13일 JAMA Neurol . Published online: April 13, 2026. Doi: 10.1001/jamaneurol.2026.0656 Abstract Importance Chronic subdural hematoma (cSDH) is among the most common neurosurgical disorders in older adults. Although short-term outcomes after surgery are favorable, long-term survival and health-related quality of life (HRQoL) remain poorly characterized. Objectives To evaluate long-t
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4월 20일4분 분량


Glioblastoma cells that evade chemoradiotherapy-induced celldeath exhibit a bifurcated glycolytic program
Emma Martell 1,2,9, Helgi Kuzmychova 1,3,9, Ujala Chawla1 , Akaljot Grewal1,3, Charul Jain1,3, Chitra Venugopal4,5, Christopher M. Anderson2,6, Sheila K. Singh 4,5,7 and Tanveer Sharif 1,3,8 Cell Death and Disease (2026) 17:348 ; https://doi.org/10.1038/s41419-026-08646-9 초록 Glioblastoma (GBM), the most common malignant brain tumor in adults, remains a highly lethal and incurable cancer, with a 5-year survival rate below 10%. Standard-of-care involves surgical resection follo
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4월 20일3분 분량


Monro-Kellie 4.0: moving from intracranial pressure to intracranial dynamics
Sérgio Brasil1*, Gustavo C. Patriota2 , Daniel Agustín Godoy3 , Jorge L. Paranhos4 , Andrés Mariano Rubiano5 and Wellingson S. Paiva Crit Care. 2025 Jun 5;29:229. doi: 10.1186/s13054-025-05476-7 Abstract The Monro-Kellie doctrine, introduced in the late 18th century, was a groundbreaking concept aimed at explaining the interactions between intracranial volume components. It has since become a cornerstone of brain physiology, now recognized as intracranial dynamics. Initial
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4월 7일2분 분량


Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles toovercome the therapeutic resistance in glioblastoma multiforme
1.논문 제목: Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme 2.저자명 : Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Alfredo Quinones-Hinojosa & Debabrata Mukhopadhyay 3.Pub lish: Communi
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4월 6일3분 분량


The regulations of telomerase reverse transcriptase (TERT) in cancer
1.논문 제목 : The regulations of telomerase reverse transcriptase (TERT) in cancer 2.저자명: Mingdi Liu , Yuning Zhang , Yongping Jian , Liting Gu , Dan Zhang , Honglan Zhou , Yishu Wang & Zhi-Xiang Xu 3.Pub lish: C ell death & disease , January, 2024 4.DO I: 10.1038/s41419-024-06454-7. 5.Abstract: Telomerase reverse transcriptase (TERT) is a key regulator of cancer progression by maintaining telomere length and enabling cells to bypass replicative senescence. In most canc
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4월 6일3분 분량


CB‑Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting
1.논문 제목: CB‑Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting 2.저자명: Yang Liu, Xiaocong Yang, Jianhong Gan, Shuang Chen, Zhi‑Xiong Xiao, Yang Cao 3.Pub lish: 2022 Jul 5 4.DO I: 10.1093/nar/gkac394 5.Abstract: Protein-ligand blind docking is a powerful method for exploring the binding sites of receptors and the corresponding binding poses of ligands. It has seen wide applications in pharmaceutical and biolo
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3월 30일3분 분량


Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026
Prescott, Hallie C. MD, MSc 1,2 ; Antonelli, Massimo MD 3,4 ; Alhazzani, Waleed MD, MSc, FRCPC 5,6,7 ; Møller, Morten Hylander MD, PhD 8,9 ; Alshamsi, Fayez MBBS 10 ; Azevedo, Luciano C. P. MD, PhD 11 ; Belley-Cote, Emilie MD, PhD 12,13,14 ; De Waele, Jan MD, PhD 15,16 ; Derde, Lennie MD, PhD 17,18 ; Dionne, Joanna C. MD, MSc, PhD, FRCPC 19,20 ; Evans, Laura MD 21 ; Gershengorn, Hayley B. MD 22,23 ; Hodgson, Carol L. PhD, PT, MPhils, PGDip(Crit Care) 24,25 ; Honarmand, Kimia
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3월 24일3분 분량


A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth
Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton E, Pastuszka MK, Sigler JJ, Tran E, Hee K, McLaughlin J, Ambrus-Aikelin G, Pollock J, Abraham RT, Kinsella TM, Simon GM, Major MB, Weinstein DS, Patricelli MP. Cancer Discov . 2025 Dec 19. doi: 10.1158/215
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3월 23일3분 분량


Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy
Emanuele Cerulli Irelli, MD, PhD1 ; Roberta Roberti, MD2 ; Maria Sole Borioni, MD1 et al 2026년 02월09일 JAMA Neurol . Published online: February 9, 2026 DOI:10.1001/jamaneurol.2025.5625 Abstract Importance Treatment decisions in drug-resistant focal epilepsy remain largely empirical, as direct comparative evidence among newer antiseizure medications (ASMs) is limited. Real-world data can complement randomized clinical trials by providing insights into long-term effectiv
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3월 23일4분 분량


High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Sohyon Lee , Tobias Weiss , Marcel Bühler , Julien Mena , Zuzanna Lottenbach , Rebekka Wegmann , Miaomiao Sun , Michel Bihl , Bartłomiej Augustynek , Sven P. Baumann , Sandra Goetze , Audrey van Drogen , Patrick G. A. Pedrioli , David Penton , Yasmin Festl , Alicia Buck , Daniel Kirschenbaum , Anna M. Zeitlberger , Marian C. Neidert , Flavio Vasella , Elisabeth J. Rushing , Bernd Wollscheid , Matthias A. Hediger , Michael Weller & Berend Snijder ...
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3월 17일3분 분량


Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
1.논문 제목: Base barrier cells provide compartmentalization of choroid plexus, brain and CSF 2.저자명: Daan Verhaege, Clint De Nolf, Lore Van Acker, Wouter Claeys, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Pieter Dujardin, Ward De Spiegelaere, Esther Hoste, Fleur Boone, Hart G. W. Lidov, Neil Dani, Julia Derk, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Saskia Lippens, Maria K. Lehtinen, Julie Siegenthaler, Lien Van Hoecke Roosmarijn E. Vandenbroucke 3.출처 및
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3월 17일3분 분량


Strategies for blood–brain barrier rejuvenation and repair
1.논문 제목: Strategies for blood–brain barrier rejuvenation and repair 2.저자명: Matthew J. Campbell, Daniel A. Nation, Anne Eichmann, Christer Betsholtz, Berislav V. Zlokovi 3.Pub lish: Nature Reviews Drug Discovery , 2026 4.DO I: 10.1038/s41573-025-01364-5 5.Abstract: Blood–brain barrier (BBB) dysfunction is a common feature of many neurological diseases such as Alzheimer disease, stroke and other neurodegenerative disorders. Although the BBB plays a crucial role in maintainin
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3월 17일3분 분량




