

The STELLAR trial: a phase II/III randomized trial of high-dose, intermittent sunitinib in patients with recurrent glioblastoma
Jorien B E Janssen 1,#, Cyrillo G Brahm 2,#, Chantal M L Driessen 3, Janine Nuver 4, Mariette Labots 5, Mathilde C M Kouwenhoven 6, Esther Sanchez Aliaga 7, Roelien H Enting 8, Jan Cees de Groot 9, Annemiek M E Walenkamp 10, Myra E van Linde 11, Henk M W Verheul 12,13,✉ Brain Commun. 2024 Jul 30;6(4):fcae241. doi: 10.1093/braincomms/fcae241 Abstract Previously, the tyrosine kinase inhibitor sunitinib failed to show clinical benefit in patients with recurrent glioblastoma.
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2일 전2분 분량


Degrading GPX4 via Biomimetic Nanoparticle-Mediated InSitu Synthesis of Deep-Learning-Designed Binder-DegronChimeras for Prostate Cancer Therapy
Si-Han Zhang, Ye An, Na Zeng, Mei-Cheng Liu, Jian-Xuan Sun, Xi Gong, Jin-Zhou Xu, Shao-Gang Wang, Qi-Dong Xia Adv Sci (Weinh) . 2026 Sep 27:e77932 Abstract Glutathione peroxidase 4 (GPX4) is a central guardian against ferroptosis and a critical therapeutic target for castration-resistant prostate cancer (CRPC). However, traditional GPX4 inhibitors are often limited by irreversible covalent binding and systemic toxicity. Here, we utilized the deep learning algorithm Bindcraft
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3일 전4분 분량


Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy
1.논문 제목: Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy. 2.저자명: Muhammad Umer Khan, Maha Munir, Hina Manzoor, Ismail Hamad, Tahir Ali Chohan, Badriyah S Alotaibi 3.Publish: 13 February 2026 4.DOI: https://doi.org/10.1038/s41598-026-39629-7 5.Abstract: Glioblastoma multiform (GBM) is the most deadly type of primary CNS tumor and is linked to dysregulation of the CDK4/6 pathway, poor prognosis, and high rate of post-surgical recurr
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3일 전4분 분량


Restrictive vs Liberal Transfusion Strategy in Traumatic Brain Injury A Secondary Analysis of the TRAIN Trial
Irene Sbaraini Zernini, MD1; Chiara Faso, MD1; Carla Bittencourt Rynkowski, MD, PhD2,3 et al 2026년09월08일 JAMA Neurol. Published online: September 8, 2026. DOI:10.1001/jamanetwokropen.2026.32555 Abstract Importance Anemia is a prevalent condition among patients with traumatic brain injury (TBI); however, the optimal hemoglobin (Hb) threshold to initiate red blood cell transfusion (RBCT) is not well defined. Objective To assess which of 2 different Hb thresholds for guidi
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10월 7일4분 분량


Ferroptosis resistance-related TEP1 as a novel prognostic biomarker involved in immune cell infiltration and tumour progression in glioblastoma
1. 논문 제목: Ferroptosis resistance-related TEP1 as a novel prognostic biomarker involved in immune cell infiltration and tumour progression in glioblastoma 2. 저자명: Kunxiang Chen, Chengzong Zhong, Yiqing Wang, Tao Liu, Huan Chen, Ruizhi Wu, Guanping Qiu, Siqi Zheng, Yong Gao, Yuean Ping, Qiang Zhou, Yuntao Lu and Hong Li 3. 출처 및 게재 (발행일): Cancer Cell International, 3 December 2025 4. DOI: https://doi.org/10.1186/s12935-025-04114-0 5. Abstract: 5-1 Background: TEP1 is a ribonucl
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9월 28일3분 분량


Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme
1.논문 제목: Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme 2.저자명: Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Alfredo Quinones-Hinojosa, Debabrata Mukhopadhyay 3.Publish: Communications
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9월 28일3분 분량


REINVENT 4: Modern AI-driven generative molecule design
1.논문 제목: REINVENT 4: Modern AI-driven generative molecule design 2.저자명: Hannes H. Loeffler, Jiazhen He, Alessandro Tibo, Jon Paul Janet, Alexey Voronov, Lewis H. Mervin, Ola Engkvist 3.Publiush: 21 February 2024 4.DOI: https://doi.org/10.1186/s13321-024-00812-5 5.Abstract: REINVENT 4 is a modern open-source generative AI framework for the design of small molecules. The software utilizes recurrent neural networks and transformer architectures to drive molecule generation. Thes
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9월 21일3분 분량


Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial
Wolfgang Wick 1, Lisa-Marie Lanz 2, Antje Wick 3, Inga Harting 4, Susan Dettmer 2, Abigail K Suwala 5, Ralf Ketter 6, Ghazaleh Tabatabai 7 8, Corinna Seliger 3 9, Martin Glas 10, Michael C Burger 11, Marco Timmer 12, Florian A Ringel 13 14, Iris Mildenberger 15 16, Walter J Schulz-Schaeffer 17, Frank Winkler 3, Laila König 18, Christel Herold-Mende 19, Andreas Eisenmenger 2, Stefan M Pfister 20, Mirjam Renovanz 7 8 21, Martin Bendszus 4, Felix Sahm 22, Michael Platten 15 16,
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9월 15일3분 분량


Lifelong De Novo Aneurysm Risk After Aneurysmal Subarachnoid Hemorrhage in Young Survivors
Peter Alpkvist, MD1,2; Caroline Lindblad, MD, PhD1,2; Mikael Svensson, MD, PhD1,2 et alet al 2026년 8월24일 JAMA Neurol Published Online: August 24, 2026 DOI: 10.1001/jama.2026.2830 Abstract Importance Young survivors of aneurysmal subarachnoid hemorrhage (aSAH) risk de novo aneurysm formation, yet population-based lifetime estimates are lacking, and prior studies were limited by selection bias and short follow-up. Objectives To determine lifetime cumulative incidence, risk fa
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9월 8일4분 분량


Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
1. 논문 제목: Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect. 2. 저자명: Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng and Aimin Li 3. 출처 및 게재 (발행일): Journal of Nanobiotechnology, 23 December 2021 4. DOI: https://doi.org/10.1186/s12951-021-01180-0 5. Abstract: The integrin αvβ3 receptor and Lactoferrin receptor (LfR) are over-expressed in both cerebral microvascular
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9월 8일3분 분량


Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy
1.논문 제목: Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy 2.저자명: Boyan Li, Xin Chen, J. Dong, S. Zhang, W. Qin, R. Zhang, Z. Peng, S. Zhang, Q. Guo, Y. Qin, W. Wang, L. Deng, S. Nie, Y. Sun, H. Xu, H. Li, G. Liu 3.Publish: Advanced Science, 2022 4.DOI: 10.1002/advs.202105451 5.Abstract: GBM은 높은 악성도와 BBB로 인해 약물이 종양에 효과적으로 전달되기 어렵다. 또한 페롭토시스를 이용한 치료에서도 암세포가 여러 방어기전을 통해 페롭토시스를 회피할 수 있다. 본 연구에
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9월 8일3분 분량


Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer
1.논문 제목: Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer 2.저자명: Congjun Xu, Zhanghong Xiao, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, Chunshun Zhao 3.Publish: September 10, 2021 4.DOI: https://doi.org/10.1021/acs.jmedchem.1c00569 5.Abstract: Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptos
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9월 1일3분 분량


GLP-1 Receptor Agonist Use Is Associated With Lower Risk of Intracranial Aneurysm Rupture and Rupture Severity
Chen H, et al. et al Epub 2026 May 21 Stroke. 2026 Jul;57(7):1979-1990 DOI: 10.1161/STROKEAHA.126.055692 Abstract Background Unruptured intracranial aneurysms (UIAs) affect up to 5% of the population, and rupture can lead to devastating subarachnoid hemorrhage. GLP-1RAs (glucagon-like peptide-1 receptor agonists) have anti-inflammatory and vasculoprotective effects, but their impact on aneurysm stability and subarachnoid hemorrhage outcomes is unexplored. This study evalu
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8월 24일3분 분량


Posttranslational modifications remodel proteome-wide ligandability
Li, W., Wei, Q., Llanos, M. et al. Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02216-y Posttranslational modifications (PTMs) vastly expand the diversity of the human proteome, dynamically reshaping protein activity, interactions and localization in response to environmental, pharmacologic and disease-associated cues. However, their proteome-wide impact on small-molecule recognition—and, thus, druggability—remains largely unexplored. Here we present a chemical pr
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8월 24일3분 분량


Evaluation of Regorafenib in Newly Diagnosed and Recurrent Glioblastoma: GBM AGILE Phase II/III Bayesian Randomized Platform Trial
Patrick Y. Wen, MD1 ; Donald A. Berry, PhD2 ; Meredith B. Buxton, PhD3 ; Howard Colman, MD, PhD, FAAN4 ; John de Groot, MD5 ; Michael Lim, MD6 ; Ingo Mellinghoff, MD7 ; James R. Perry, MD, FRCPC, FAAN8 ; Michael Weller, MD9 ; Nicholas A. Blondin, MD10; Omar H. Butt, MD, PhD, MS11 ; Denise M. Damek, MD12; Macarena I. de la Fuente, MD13 ; Jan Drappatz, MD14; Erin Dunbar, MD15; Pierre Giglio, MD16; Emma Viktoria Hyddmark, PhD3 ; Fabio Iwamoto, MD17; Kurt A. Jaeckle, MD18 ; Lyndo
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8월 18일3분 분량


Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment
1.논문 제목: Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment 2.저자명: Zahra Abousalman-Rezvani, Ahmed Refaat, Pouya Dehghankelishadi, Hossein Roghani-Mamaqani, Lars Esser, and Nicolas H. Voelcker 3. 출처 및 게재 : Advanced Healthcare Materials, 7 March 2024 4. DOI: https://doi.org/10.1002/adhm.202302902 5. Abstract: Brain cancers, especially glioblastoma multiforme, are associated with poor prognosis due to the limited efficacy of current therapies
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8월 18일3분 분량


Preparation and application of pH-responsive drug delivery systems
1.논문 제목: Preparation and application of pH-responsive drug delivery systems 2.저자명: Haitao Ding, Ping Tan, Shiqin Fu, Xiaohe Tian, Hu Zhang, Xuelei Ma, Zhongwei Gu, Kui Luo. 3.출처 및 게재일: Journal of Controlled Release, 2022 4.DOI: 10.1016/j.jconrel.2022.05.056 5.Abstract: pH-responsive drug delivery systems are designed to exploit differences in pH between normal and pathological tissues to achieve controlled and site-specific drug release. Because tumors, inflammatory tissues,
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8월 18일4분 분량


Middle Meningeal Artery Embolization With n-Butyl Cyanoacrylate in Patients With Chronic Subdural HematomaA Randomized Clinical Trial
Christopher P. Kellner, MD1; Ansaar T. Rai, MD2; Hazem Shoirah, MD1 et alet al 2026년 6월 15일 JAMA Published Online: June 15, 2026 DOI: 10.1001/jama.2026.1542 Abstract Importance Middle meningeal artery embolization (MMAE) is a minimally invasive adjunctive treatment for chronic subdural hematoma (cSDH). The TRUFILL n-butyl cyanoacrylate (n-BCA) liquid embolic system is indicated for embolization of cerebral arteriovenous malformations for presurgical devascularization and may
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8월 10일3분 분량


Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
1.논문 제목: Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells 2.저자명: Shengjie Peng, Guodong Chen, K. N. Yu, Yue Feng, Lele Zhao, Miaomiao Yang, Wei Cao, Waleed Abdelbagi Ahmed Almahi, Mingyu Sun, Yuan Xu, Ye Zhao, Cheng Cheng, Fengqin Zhu, Wei Han. 3.Publish: 12 February 2024 4.DOI: 10.1186/s12964-023-01382-z 5.Abstract: Though (1S, 3R)-RSL3 has been used widely
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8월 10일5분 분량


Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Governa et al., Proceedings of the National Academy of Sciences, 2022 DOI: 10.1073/pnas.2114456119 Therapeutic strategies directed at the tumor surfaceome (TS),including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have deve
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8월 10일5분 분량




