

Molecularly matched targeted therapies plus radiotherapy in glioblastoma: the phase 1/2a N2M2 umbrella trial
Wolfgang Wick 1, Lisa-Marie Lanz 2, Antje Wick 3, Inga Harting 4, Susan Dettmer 2, Abigail K Suwala 5, Ralf Ketter 6, Ghazaleh Tabatabai 7 8, Corinna Seliger 3 9, Martin Glas 10, Michael C Burger 11, Marco Timmer 12, Florian A Ringel 13 14, Iris Mildenberger 15 16, Walter J Schulz-Schaeffer 17, Frank Winkler 3, Laila König 18, Christel Herold-Mende 19, Andreas Eisenmenger 2, Stefan M Pfister 20, Mirjam Renovanz 7 8 21, Martin Bendszus 4, Felix Sahm 22, Michael Platten 15 16,
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14시간 전3분 분량


Lifelong De Novo Aneurysm Risk After Aneurysmal Subarachnoid Hemorrhage in Young Survivors
Peter Alpkvist, MD1,2; Caroline Lindblad, MD, PhD1,2; Mikael Svensson, MD, PhD1,2 et alet al 2026년 8월24일 JAMA Neurol Published Online: August 24, 2026 DOI: 10.1001/jama.2026.2830 Abstract Importance Young survivors of aneurysmal subarachnoid hemorrhage (aSAH) risk de novo aneurysm formation, yet population-based lifetime estimates are lacking, and prior studies were limited by selection bias and short follow-up. Objectives To determine lifetime cumulative incidence, risk fa
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9월 8일4분 분량


Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
1. 논문 제목: Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect. 2. 저자명: Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng and Aimin Li 3. 출처 및 게재 (발행일): Journal of Nanobiotechnology, 23 December 2021 4. DOI: https://doi.org/10.1186/s12951-021-01180-0 5. Abstract: The integrin αvβ3 receptor and Lactoferrin receptor (LfR) are over-expressed in both cerebral microvascular
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9월 8일3분 분량


Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy
1.논문 제목: Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy 2.저자명: Boyan Li, Xin Chen, J. Dong, S. Zhang, W. Qin, R. Zhang, Z. Peng, S. Zhang, Q. Guo, Y. Qin, W. Wang, L. Deng, S. Nie, Y. Sun, H. Xu, H. Li, G. Liu 3.Publish: Advanced Science, 2022 4.DOI: 10.1002/advs.202105451 5.Abstract: GBM은 높은 악성도와 BBB로 인해 약물이 종양에 효과적으로 전달되기 어렵다. 또한 페롭토시스를 이용한 치료에서도 암세포가 여러 방어기전을 통해 페롭토시스를 회피할 수 있다. 본 연구에
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9월 8일3분 분량


Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer
1.논문 제목: Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer 2.저자명: Congjun Xu, Zhanghong Xiao, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, Chunshun Zhao 3.Publish: September 10, 2021 4.DOI: https://doi.org/10.1021/acs.jmedchem.1c00569 5.Abstract: Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptos
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9월 1일3분 분량


GLP-1 Receptor Agonist Use Is Associated With Lower Risk of Intracranial Aneurysm Rupture and Rupture Severity
Chen H, et al. et al Epub 2026 May 21 Stroke. 2026 Jul;57(7):1979-1990 DOI: 10.1161/STROKEAHA.126.055692 Abstract Background Unruptured intracranial aneurysms (UIAs) affect up to 5% of the population, and rupture can lead to devastating subarachnoid hemorrhage. GLP-1RAs (glucagon-like peptide-1 receptor agonists) have anti-inflammatory and vasculoprotective effects, but their impact on aneurysm stability and subarachnoid hemorrhage outcomes is unexplored. This study evalu
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8월 24일3분 분량


Posttranslational modifications remodel proteome-wide ligandability
Li, W., Wei, Q., Llanos, M. et al. Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02216-y Posttranslational modifications (PTMs) vastly expand the diversity of the human proteome, dynamically reshaping protein activity, interactions and localization in response to environmental, pharmacologic and disease-associated cues. However, their proteome-wide impact on small-molecule recognition—and, thus, druggability—remains largely unexplored. Here we present a chemical pr
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8월 24일3분 분량


Evaluation of Regorafenib in Newly Diagnosed and Recurrent Glioblastoma: GBM AGILE Phase II/III Bayesian Randomized Platform Trial
Patrick Y. Wen, MD1 ; Donald A. Berry, PhD2 ; Meredith B. Buxton, PhD3 ; Howard Colman, MD, PhD, FAAN4 ; John de Groot, MD5 ; Michael Lim, MD6 ; Ingo Mellinghoff, MD7 ; James R. Perry, MD, FRCPC, FAAN8 ; Michael Weller, MD9 ; Nicholas A. Blondin, MD10; Omar H. Butt, MD, PhD, MS11 ; Denise M. Damek, MD12; Macarena I. de la Fuente, MD13 ; Jan Drappatz, MD14; Erin Dunbar, MD15; Pierre Giglio, MD16; Emma Viktoria Hyddmark, PhD3 ; Fabio Iwamoto, MD17; Kurt A. Jaeckle, MD18 ; Lyndo
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8월 18일3분 분량


Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment
1.논문 제목: Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment 2.저자명: Zahra Abousalman-Rezvani, Ahmed Refaat, Pouya Dehghankelishadi, Hossein Roghani-Mamaqani, Lars Esser, and Nicolas H. Voelcker 3. 출처 및 게재 : Advanced Healthcare Materials, 7 March 2024 4. DOI: https://doi.org/10.1002/adhm.202302902 5. Abstract: Brain cancers, especially glioblastoma multiforme, are associated with poor prognosis due to the limited efficacy of current therapies
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8월 18일3분 분량


Preparation and application of pH-responsive drug delivery systems
1.논문 제목: Preparation and application of pH-responsive drug delivery systems 2.저자명: Haitao Ding, Ping Tan, Shiqin Fu, Xiaohe Tian, Hu Zhang, Xuelei Ma, Zhongwei Gu, Kui Luo. 3.출처 및 게재일: Journal of Controlled Release, 2022 4.DOI: 10.1016/j.jconrel.2022.05.056 5.Abstract: pH-responsive drug delivery systems are designed to exploit differences in pH between normal and pathological tissues to achieve controlled and site-specific drug release. Because tumors, inflammatory tissues,
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8월 18일4분 분량


Middle Meningeal Artery Embolization With n-Butyl Cyanoacrylate in Patients With Chronic Subdural HematomaA Randomized Clinical Trial
Christopher P. Kellner, MD1; Ansaar T. Rai, MD2; Hazem Shoirah, MD1 et alet al 2026년 6월 15일 JAMA Published Online: June 15, 2026 DOI: 10.1001/jama.2026.1542 Abstract Importance Middle meningeal artery embolization (MMAE) is a minimally invasive adjunctive treatment for chronic subdural hematoma (cSDH). The TRUFILL n-butyl cyanoacrylate (n-BCA) liquid embolic system is indicated for embolization of cerebral arteriovenous malformations for presurgical devascularization and may
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8월 10일3분 분량


Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
1.논문 제목: Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells 2.저자명: Shengjie Peng, Guodong Chen, K. N. Yu, Yue Feng, Lele Zhao, Miaomiao Yang, Wei Cao, Waleed Abdelbagi Ahmed Almahi, Mingyu Sun, Yuan Xu, Ye Zhao, Cheng Cheng, Fengqin Zhu, Wei Han. 3.Publish: 12 February 2024 4.DOI: 10.1186/s12964-023-01382-z 5.Abstract: Though (1S, 3R)-RSL3 has been used widely
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8월 10일5분 분량


Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Governa et al., Proceedings of the National Academy of Sciences, 2022 DOI: 10.1073/pnas.2114456119 Therapeutic strategies directed at the tumor surfaceome (TS),including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have deve
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8월 10일5분 분량


Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain
1. 논문 제목: Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain 2. 저자명: Fei-Cheng Yang, Chuan Wang, Jiang Zhu, Qu-Jing Gai, Min Mao, Jiang He, Yan Qin, Xiao-Xue Yao, Yan-Xia Wang, Hui-Min Lu, Mian-Fu Cao, Ming-Min He, Xian-Mei Wen, Ping Leng, Xiong-Wei Cai, Xiao-Hong Yao, Xiu-Wu Bian and Yan Wang 3. 출처 및 게재 (발행일): Laboratory Investigation, 25 Feb
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8월 3일3분 분량


Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
1.논문 제목: Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. 2.저자명: Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent Stockwell, Guido Kroemer, Rui Kang, Daolin Tang. 3.Publish: Science Translational Medicine, 1 November, 2023 4.DOI: 10.1126/scitranslmed.adg3049 5.Abstract: Current ferroptosis inducers effectively kill cancer cells by inhibiting GPX4 but also damage immune cells,
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8월 3일3분 분량


Cerebral Amyloid Angiopathy
Steven M. Greenberg, M.D., Ph.D 2026년 5월 6일 N Engl J Med 2026;394:1836-1845 DOI: 10.1056/NEJMra2411298 Summary Cerebral amyloid angiopathy is a major cause of hemorrhagic stroke, a frequent contributor to age-related cognitive impairment, and a key component in adverse responses to beta-amyloid (Aβ) immunotherapy. Defined by pathological deposition of Aβ in the small blood vessels of the brain, cerebral amyloid angiopathy is most often diagnosed on the basis of magnetic res
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7월 29일4분 분량


Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma
1.논문 제목: Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma 2.저자명: Xinyu He, Yubing Zhou, Wenjing Chen, Xiaokun Zhao, Lina Duan, Hao Zhou, Mingzhu Li, Yin Yu, Jimin Zhao, Yaping Guo, Huihui Gu, Yanan Jiang, Zigang Dong, Kangdong Liu 3.Publish: 25 February 2023 4.DOI: https://doi.org/10.1038/s41388-023-02636-3 5.Abstract: Targeted therapy attempts are needed to enhance esophageal squamous c
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7월 27일4분 분량


ARE-PROTACs Enable Co-degradation of an Nrf2–MafG Heterodimer
Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z. ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer. J Med Chem. 2023 May 11;66(9):6070-6081. doi: 10.1021/acs.jmedchem.2c01909. Proteolysis-targeting chimera (PROTAC) technology has emerged as a potential strategy to degrade “undruggable” proteins in recent years. Nrf2, an aberrantly activated transcription factor in cancer, is generally considered undruggable as lacking active sites or allosteric pockets. Here, we
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7월 21일3분 분량


Recent Advances and Future Prospects in Gene Delivery Platforms for Glioblastoma : A Review
1. Alexander F. Haddad, MD1; Rithvik Ramesh, BA1; Jorge Armando Peña Agudelo, PhD2,3 JAMA Neurol Published Online: July 13, 2026 doi: 10.1001/jamaneurol.2026.2131 Abstract Importance Glioblastoma (GBM) remains a disease with high mortality despite treatment with maximal safe surgical resection, radiation, and temozolomide. Standard of care for GBM has remained unchanged for decades. Gene therapies using both viral and nonviral platforms have the potential to significantl
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7월 20일2분 분량


Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers
Yael Rosen-Lang, MPH1; Agathe Vrillon, MD, PhD2,3; Shlomit Pasternak, MSc1 et al 2026년 06월 29일 JAMA Published Online: June 29, 2026 DOI: 10.1001/jamaneurol.2026.2042 Abstract Importance Traumatic brain injury (TBI) is a risk factor for dementia and is known to impact levels of several Alzheimer disease (AD) blood biomarkers. The plasma phosphorylated tau 217 (p-tau217)/amyloid-β 42 (Aβ42) ratio has been reported to be 90% accurate for the detection of brain amyloid in civili
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7월 14일4분 분량




