

Risk of Future Hemorrhage From Unruptured Brain Arteriovenous Malformations The Multicenter Arteriovenous Malformation Research Study (MARS)
Helen Kim, PhD1,2 ; Jeffrey Nelson, MS1 ; Charles E. McCulloch, PhD2 et al 2025년 10월6일 JAMA Neurol . Published online: October 6, 2025. Doi: 10.1001/jamaneurol.2025.3581 Abstract Importance Annual rates of first intracranial hemorrhage (ICH) from unruptured brain arteriovenous malformations (AVMs) are often quoted as 2% to 4% in clinical practice. Precise estimates and risk factors are unavailable to inform treatment decisions. Objectives To provide estimates of ra
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11분 전4분 분량


Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutantGBM to AZD1390-mediated radiosensitization.
논문 제목 : Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. 저자명 : Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Ashwin Bale, Brett L. Carlson, Kendra A. Porath, Katrina K. Bakken, Danielle M. Burgenske, Paul A. Decker, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan Harley, William F. Elmquist, Zachary D. Nagel, Shiv K. Gupta, Jann N. Sarkaria.
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19시간 전3분 분량


Virtual Screening Directly Identifies New Fragment-Sized Inhibitorsof Carboxylesterase Notum with Nanomolar Activity
논문 제목 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity 저자명 David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish,* and Fredrik Svensson Publish 2022 Jan 13 DOI https://doi.org/10.1021/acs.jmedchem.1c01735 Abstract Notum is a negative regulator of Wnt signalin
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23시간 전4분 분량


Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM.
논문 제목 Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM. 저자명 Jorge L. Jimenez-Macias, Philippa Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan Forrest, Jason Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William Hawkins, Noe Mercado, Jacqueline Real, Kelsey Huntington, Mykola Zdioruk, Michal O. Nowicki, Choi-Fong Cho, Bin Wu, Weiyi Li, Theresa Logan, Katherine E. Manz, Kurt D. Pennell, Bogda
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23시간 전3분 분량


Glioblastoma remodeling of human neural circuits decreases survival.
1. 논문 제목: Glioblastoma remodeling of human neural circuits decreases survival. 2. 저자명: Saritha Krishna, Abrar Choudhury, Michael B. Keough, Kyounghee Seo, Lijun Ni, Sofia Kakaizada, Anthony Lee, Alexander Aabedi, Galina Popova, Benjamin Lipkin, Caroline Cao, Cesar Nava Gonzales, Rasika Sudharshan, Andrew Egladyous, Nyle Almeida, Yalan Zhang, Annette M. Molinaro, Humsa S. Venkatesh, Andy G. S. Daniel, Kiarash Shamardani, Jeanette Hyer, Edward F. Chang, Anne Findlay, Joanna
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23시간 전2분 분량


The intensive care medicine research agenda for the management of ICU acquired weakness: a multinational, interprofessional perspective
Intensive Care Med, Volume 51, pages 2199-2212, (2025) Conference Repors and Expert Panel, Published: 03 November 2025 Doi: 10.1007/s00134-025-08186-4 Abstract Intensive care unit acquired weakness (ICUAW) is common in critically ill patients, contributing to substantial morbidity. Major trials and novel mechanistic findings published over the past years have advanced knowledge for the prevention and treatment of ICUAW. To streamline future research priorities, a multinat
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7일 전3분 분량


European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2025: post-resuscitation care
Intensive Care Med, Volume 51, pages 2213-2288, (2025) Conference Repors and Expert Panel, Published: 22 October 2025 Doi: 10.1007/s00134-025-08117-3 Abstract The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) have collaborated to produce these post-resuscitation care guidelines for adults, which are based on the International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations (CoSTR) pubis
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7일 전3분 분량


Glioblastoma and Other Primary Brain Malignancies in Adults A Review
Lauren R. Schaff, MD 1,2 ; Ingo K. Mellinghoff, MD 1,2,3,4 JAMA Published Online: February 21, 2023 2023;329;(7):574-587. doi:10.1001/jama.2023.0023 Abstract Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the United States. The annual incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals and increases with age. Five-year survival is approximately 36%. Observations Approximately 49% of malignant brain
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12월 15일3분 분량


Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus
1. 논문 제목: Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus 2. 저자명: Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao,
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12월 15일2분 분량


Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
D Azorín D, Hoffmann DC, Hebach NR, Jung E, Hausmann D, Ratliff M, Hai L, Horschitz S, Jabali A, Osswald M, Karreman MA, Kessler T, Wendler S, Mayer CD, Löb C, Lehnert P, Cebulla G, Reibold D, Khajuria RK, Bordignon P, Moor AE, Holland-Letz T, Reckless J, Ramsden N, Grainger D, Kreshuk A, Koch P, Wick W, Heuer S, Winkler F. Cancer Discovery. 2025 Oct 9. doi: 10.1158/2159-8290.CD-24-0414 영문초록 Glioblastomas are incurable primary brain tumors that depend on neural-like cellula
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12월 11일3분 분량


AI-Powered Virtual Screening of Large Compound Libraries Leads to the Discovery of Novel Inhibitors of Sirtuin-1
Anastasiia Gryniukova, Florian Kaiser, Iryna Myziuk, Diana Alieksieieva, Christoph Leberecht, Peter P. Heym, Olga O. Tarkhanova, Yurii S. Moroz, Petro Borysko, V. Joachim Haupt 10.1021/acs.jmedchem.3c00128 Abstract The discovery of new scaffolds and chemotypes via high-throughput screening is tedious and resource intensive. Yet, there are millions of small molecules commercially available, rendering comprehensive in vitro tests intractable. We show how smart algorithms reduce
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11월 25일4분 분량


Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection
Xue Li, Hyun Jung Kim, Jihwan Yoo, Yeonhee Lee, Chang Hyun Nam, Jonghan Park, Soon-Tae Lee, Tae Min Kim, Seung Hong Choi, Jae-Kyung Won, Sung‑Hye Park, Young Seok Ju, Jong Bae Park, Se Hoon Kim, Jong Hee Chang, Hong-Gyun Wu, Chul-Kee Park, Jeong Ho Lee, Seok-Gu Kang & Joo Ho Lee Molecular Cancer volume 24, Article number: 64 (2025) Abstract (원문 요약) Glioblastoma (GBM) is the most aggressive and common type of primary malignant brain cancer in adults. GBM often recurs locally
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11월 25일3분 분량
Glioblastoma and brain connectivity: the need for a paradigm shift
Alessandro Salvalaggio, MD a,b,c ∙ Lorenzo Pini, PhD b ∙ Prof Alessandra Bertoldo, PhD c,d ∙ Prof Maurizio Corbetta, MD a,b,c,e maurizio.corbetta@unipd.it Publication History: Published July 2024 DOI: 10.1016/S1474-4422(24)00160-1 External Link Also available on ScienceDirect External Link Copyright: © 2024 Elsevier Ltd. All rights reserved. Summary Despite substantial advances in cancer treatment, for patients with glioblastoma prognosis remains bleak. The emer
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11월 24일2분 분량


Neuropathy A Review
Michelle L. Mauermann, MD1 ; Nathan P. Staff, MD, PhD1 2025년 11월 17일 JAMA Published Online: November 17, 2025 DOI: 10.1001/jama.2025.19400 Abstract Importance Peripheral neuropathy, defined as damage to peripheral nerves, affects approximately 1% of adults worldwide. More than 200 causes of peripheral neuropathy exist, with symptoms ranging in severity from mild toe numbness to debilitating symptoms that can require a wheelchair. Diabetes is the most common cause of neurop
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11월 18일2분 분량


Designing allosteric modulators to change GPCR G protein subtype selectivity
🔹 Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Lawrence S. Barak, Ezequiel Marron Fernandez de Velasco, Steven H. Olson & Lauren M. Slosky Nature (2025). https://doi.org/10.1038/s41586-025-09643-2 abstract G-protein-coupled receptors (GPCRs) convert extracellular signals into intracellular responses by signalling through 16 subtypes of Gα prot
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11월 18일4분 분량


Preclinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH–Wild-type Glioblastoma
Rachael A Vaubel # 1 , Wenjuan Zhang # 2 , Ju-Hee Oh 2 , Ann C Mladek 1 , Tugce I Pasa 1 , Jennifer K Gantchev 3 , Katie L Waller 1 , Gerard Baquer 3 , Sylwia A Stopka 3 , Michael S Regan 3 , Md Amin Hossain 3 , Paul A Decker 1 , Matthew L Kosel 1 , Shiv K Gupta 1 , Sonia Jain 1 , Paige P Sarkaria 1 , Zeng Hu 1 , Lauren L Ott 1 , Brett L Carlson 1 , Katie K Bakken 1 , Surabhi Talele 2 , Wenqiu Zhang 2 , Kei
한울 전
11월 18일5분 분량


Burden of Central Nervous System Cancer in the United States, 1990-2021
GBD 2021 US CNS Cancer Collaborators 2025년 11월3일 JAMA Neurol . Published online: November 3, 2025. Doi: 10.1001/jamaneurol.2025.4286 Abstract Importance Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States. Objectives To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and S
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11월 11일3분 분량


Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich Science Translational Medicine, 5 January 2022 https://www.science.org/doi/10.1126/scitranslmed.abf3917 Abstract 영문 Glioblastomas (GBMs) are lethal brain tumors containing self-renewing glioblastoma stem cells (G
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11월 10일3분 분량


Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin & Maria K. Lehtinen Nature commumications, 19 January 2021 http://doi.org/10.1038/s41467-020-20666-3 Abstract: Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neu
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11월 10일2분 분량


Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar
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11월 4일2분 분량








