

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026
Prescott, Hallie C. MD, MSc 1,2 ; Antonelli, Massimo MD 3,4 ; Alhazzani, Waleed MD, MSc, FRCPC 5,6,7 ; Møller, Morten Hylander MD, PhD 8,9 ; Alshamsi, Fayez MBBS 10 ; Azevedo, Luciano C. P. MD, PhD 11 ; Belley-Cote, Emilie MD, PhD 12,13,14 ; De Waele, Jan MD, PhD 15,16 ; Derde, Lennie MD, PhD 17,18 ; Dionne, Joanna C. MD, MSc, PhD, FRCPC 19,20 ; Evans, Laura MD 21 ; Gershengorn, Hayley B. MD 22,23 ; Hodgson, Carol L. PhD, PT, MPhils, PGDip(Crit Care) 24,25 ; Honarmand, Kimia
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3일 전3분 분량


A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth
Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton E, Pastuszka MK, Sigler JJ, Tran E, Hee K, McLaughlin J, Ambrus-Aikelin G, Pollock J, Abraham RT, Kinsella TM, Simon GM, Major MB, Weinstein DS, Patricelli MP. Cancer Discov . 2025 Dec 19. doi: 10.1158/215
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4일 전3분 분량


Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy
Emanuele Cerulli Irelli, MD, PhD1 ; Roberta Roberti, MD2 ; Maria Sole Borioni, MD1 et al 2026년 02월09일 JAMA Neurol . Published online: February 9, 2026 DOI:10.1001/jamaneurol.2025.5625 Abstract Importance Treatment decisions in drug-resistant focal epilepsy remain largely empirical, as direct comparative evidence among newer antiseizure medications (ASMs) is limited. Real-world data can complement randomized clinical trials by providing insights into long-term effectiv
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4일 전4분 분량


High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Sohyon Lee , Tobias Weiss , Marcel Bühler , Julien Mena , Zuzanna Lottenbach , Rebekka Wegmann , Miaomiao Sun , Michel Bihl , Bartłomiej Augustynek , Sven P. Baumann , Sandra Goetze , Audrey van Drogen , Patrick G. A. Pedrioli , David Penton , Yasmin Festl , Alicia Buck , Daniel Kirschenbaum , Anna M. Zeitlberger , Marian C. Neidert , Flavio Vasella , Elisabeth J. Rushing , Bernd Wollscheid , Matthias A. Hediger , Michael Weller & Berend Snijder ...
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3월 17일3분 분량


Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
1.논문 제목: Base barrier cells provide compartmentalization of choroid plexus, brain and CSF 2.저자명: Daan Verhaege, Clint De Nolf, Lore Van Acker, Wouter Claeys, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Pieter Dujardin, Ward De Spiegelaere, Esther Hoste, Fleur Boone, Hart G. W. Lidov, Neil Dani, Julia Derk, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Saskia Lippens, Maria K. Lehtinen, Julie Siegenthaler, Lien Van Hoecke Roosmarijn E. Vandenbroucke 3.출처 및
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3월 17일3분 분량


Strategies for blood–brain barrier rejuvenation and repair
1.논문 제목: Strategies for blood–brain barrier rejuvenation and repair 2.저자명: Matthew J. Campbell, Daniel A. Nation, Anne Eichmann, Christer Betsholtz, Berislav V. Zlokovi 3.Pub lish: Nature Reviews Drug Discovery , 2026 4.DO I: 10.1038/s41573-025-01364-5 5.Abstract: Blood–brain barrier (BBB) dysfunction is a common feature of many neurological diseases such as Alzheimer disease, stroke and other neurodegenerative disorders. Although the BBB plays a crucial role in maintainin
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3월 17일3분 분량


Evaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis
1.논문 제목: Evaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis 2.저자명: Adriana Gálvez-Ramírez, Abigail González-Valdez, Beatriz Hernández-Ochoa, Luis Miguel Canseco-Ávila, Alexander López-Roblero, Roberto Arreguin-Espinosa, Verónica Pérez de la Cruz, Elizabeth Hernández-Urzua, Noemi Cárdenas-Rodríguez, Sergio Enríquez-Flores, Ignacio De la Mora-De la Mora, Abraham Vidal-Limon, Saúl Gómez-Manzo 3.게재일: 2024 Nov 2
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3월 12일3분 분량


A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative
Prof Geoffrey T Manley MD a , Prof Kristen Dams-O’Connor PhD b * , Michael L Alosco PhD c , Hibah O Awwad PhD d, Prof Jeffery J Bazarian MD e , Prof Peter Bragge BPhysio f , Prof John D Corrigan PhD g , Adele Doperalski PhD d, Prof Adam R Ferguson PhD a h , Prof Christine L Mac Donald PhD i , Prof David K Menon MD j , Prof Molly M McNett PhD k , Prof Joukje van der Naalt MD l , Prof Lindsay D Nelson PhD m , Dana Pisică MD n, Prof Noah D Silverberg PhD o...
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3월 9일2분 분량


One-Year Outcomes After Traumatic Brain Injury and Early Extracranial Surgery in the TRACK-TBI Study
Christopher J. Roberts, MD, PhD1,2 ; Amelia W. Maiga, MD, MPH3,4,5 ; Jason Barber, MS6 ; et al 2025년10월 10일 JAMA Netw Open Published Online: October 10, 2025 DOI: 10.1001/jamanetworkopen.2025.372271 Abstract Importance Exposure to extracranial (EC) surgery early after traumatic brain injury (TBI) is associated with cognitive risks. Objective To examine whether exposure to EC surgery during a TBI index admission is associated with worse outcomes at 1 year compared with n
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3월 4일4분 분량


NRF2: KEAPing Tumors Protected
Pillai R, Hayashi M, Zavitsanou AM, Papagiannakopoulos T Cancer Discov. 2022 Mar 1;12(3):625-643. doi: 10.1158/2159-8290.CD-21-0922. The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2– related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of
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3월 3일3분 분량


Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSFhypersecretion and ventriculomegaly in hydrocephalus.
1. 논문 제목 : Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus 2. 저자명: Wu Zheng, Lanxin Hu, Yuwen Yang, Xuhang Li, JiaWu, Wangchao Chen, Yiwei Jiang, Yuhan Chen, Hongcai Wang, Shiwei Li, Kuan Feng, Cheng Zheng, Yanjiang Wang, Rodrigo A. Cunha, Zhongyue Lv & Jiang-Fan Chen 3. 출처 및 게재 (발행일): Nature communications, 07 December 2025 4. DOI : https://doi.org/10.1038/s41467-025-66776-8 5. Abstract: Hyd
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2월 24일3분 분량


Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth.
1.논문 제목: Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth. 2.저자명: Huali Su, Yaogang Zhong, Liqing He, Feng Geng, Xinmin Yin, Yongjun Kou, Cheng-Yao Chiang, Xiaokui Mo, Yunzhou Fan, Yanwei Liu, Qiang Wang, Shino Magaki, Timothy F. Cloughesy, Etienne Lefai, William H Yong, Arnab Chakravarti, Xiang Zhang, and Deliang Guo 3.Publish : 18 April 2025 4.DOI : 10.1126/sciadv.adq0334 5.Abstract: Gli
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2월 23일2분 분량


Glioma-associated microglia potentiate neuronal hyper-excitability in the glioma environment.
1.논문 제목 : Glioma-associated microglia potentiate neuronal hyper-excitability in the glioma environment. 2.저자명 : Jaeseung Yei, Na Kyeong Lee, Seungmin Ryu, Seong-Eun Ryu, Juheon Lee, Taeyoung Park, Yoonyi Jeong, Rian Kang, Ho-Keun Kwon, Seong-Gi Kim, Jong-Chan Park, Chun Gwon Park, and Minah Suh 3.Publish: 2025 July 30 4.DOI: https://doi.org/10.1093/neuonc/noaf181 5.Abstract: Hyper-excitable neurons are observed in the glioma brain, contributing to the notorious nature of g
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2월 20일3분 분량
The Next Era of Idiopathic Normal Pressure Hydrocephalus
Michael A. Williams, MD1 ; Mark G. Luciano, MD, PhD2 ; Jan Malm, MD, PhD3 et al 2026년02월06일 JAMA Neurol . Published online: February 2, 2026. Doi: 10.1001/jamaneurol.2025.5412 1965년 정상압 수두증(NPH)이 치료 가능한 치매의 한 형태 로 처음 기술된 이후, NPH에 대한 열광과 기대의 시대가 시작되었다. 당시에는 치매에 대한 치료가 거의 없었거나 상상조차 어려웠다. 곧 많은 치매 환자들이 방사성 동위원소 cisternography나 pneumo-encephalography를 기반으로 NPH로 진단받고 션트 수술을 받게 되었다. 초기에는 긍정적인 보고들이 쏟아졌지만, 이후 연구 결과에서는 점차 좋지 않은 결과들이 나타나기 시작했다. 1992년에 발표된 정상압 수두증에서 션트 수술의 이익이 위험
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2월 20일3분 분량


Dehydroepiandrosterone-α-2-Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF-7 Breast Cancer Cells and Inhibits Glucose-6-Phosphate Dehydrogenase Activity.
1.논문 제목: Dehydroepiandrosterone-α-2-Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF-7 Breast Cancer Cells and Inhibits Glucose-6-Phosphate Dehydrogenase Activity. 2.저자명: Hsu-Feng Liu, Shen-Chieh Chou, Sheng-Cih Huang, Tzu-Yu Huang, Po-Yun Hsiao, Feng-Pai Chou, Tung-Kung Wu 3.Publish : 26 August 2024 4.DOI : 10.1111/cbdd.14624 5.Abstract: In the pentose phosphate pathway, dehydroepiandrosterone (DHEA) uncompetitively inhibits glucose-6-phosphate dehydrogenase
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2월 20일2분 분량


Glioblastoma at the crossroads: current understanding and future therapeutic horizons
Shilpi Singh , Devanjan Dey , Debashis Barik , Iteeshree Mohapatra , Stefan Kim , Mayur Sharma , Sujata Prasad , Peize Wang , Amar Singh and Gatikrushna Singh Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patient survival. This review provides a comprehensive exploration of the molecular and genetic landscape of GBM, focusing on key oncogenic drivers, such as epidermal growth factor receptor (EGFR), platelet
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2월 19일3분 분량


Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation
Ana Koperniku*, Adriana A. Garcia, and Daria Mochly-Rosen Journal of Medicinal Chemistry 2022, 65, 6, 4403-4423 초록 We present an overview of small molecule glucose6-phosphate dehydrogenase (G6PD) inhibitors that have potential for use in the treatment of cancer, infectious diseases, and inflammation. Both steroidal and nonsteroidal inhibitors have been identified with steroidal inhibitors lacking target selectivity. The main scaffolds encountered in nonsteroidal inhibitors
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2월 9일3분 분량


INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stemcell model.
1. 논문 제목: INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model. 2. 저자명: Patrick A. DeSouza, Matthew Ishahak, Xuan Qu, Colin McCornack, Devi Annamalai, Diane D.Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T. Vessoni, Ryan T. Cleary, Rowland H. Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, TingWang, Luis F. Z. Batista
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2월 2일4분 분량


Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models.
논문 제목 : Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models. 저자명 : Miaomiao Sun, Maciej Bialasek, Maud Mayoux, Meng-Syuan Lin, Alicia Buck, Ilona Marszałek, Bartłomiej Taciak, Marcel Bühler, Małgorzata Górczak, Paulina Kucharzewska, Daria Kurpiel, Małgorzata Siemińska, Julia Nowakowska Brancewicz, Konrad Gabrusiewicz, Waldemar Lipiński, Sibylle Pfammatter, Steve Pascolo Gregor Hutter, Lubomi
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2월 2일3분 분량


Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity.
논문 제목 : Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity. 저자명 : Xuepeng Wei, Kathryn Kixmoeller c, Elana Baltrusaitis c, Xiaolu Yang d, Ronen Marmorstein Publish : 2022, Jul 12 DOI : https://doi.org/10.1073/pnas.2119695119 Abstract : Human glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH, and thus plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such
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1월 27일4분 분량




