

Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar
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2일 전2분 분량


The Blood−Brain Barrier (BBB) Score
Mayuri Gupta, Hyeok Jun Lee, Christopher J. Barden, and Donald F. Weaver 10.1021/acs.jmedchem.9b01220 Abstract The blood−brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations. Understanding the BBB interaction with drug molecules based on physicochemical property space can guide effective and efficient d
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2일 전3분 분량


Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas A Randomized Clinical Trial
Chengcheng Guo, MD, PhD 1 ; Qunying Yang, MD, PhD 1 ; Pengfei Xu, MD, PhD 1 Meiling Deng, MD, PhD 2 ; Taipeng Jiang, MD, PhD 3 ; Linbo Cai, MD, PhD 4 ; Jibin Li, MD, PhD 5 ; Ke Sai, MD, PhD 1 ; Shaoyan Xi, MD, PhD 6 ; Hui Ouyang, MD, PhD 7 ; Mingfa Liu, MD, PhD 8 ; Xianming Li, MD, PhD 9,10 ; Zihuang Li, MD, PhD 9,10 ; Xiangrong Ni, MD, PhD 1 ; Xi Cao, BSN 1 ; Cong Li, MD, PhD 11,12 ; Shaoxiong Wu, MD, PhD 2 ; Xiaojing Du, MD, PhD 2 ; Jun Su, MD, PhD 13 ; Xi
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3일 전4분 분량
SOFA-2: 장기부전 평가의 새로운 시대
JAMA 2025. Ranzani et al.-30년 만의 전면 개정
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7일 전1분 분량


Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Otavio T. Ranzani, MD, MSc, PhD 1,2,3 ; Mervyn Singer, MD 4 ; Jorge I. F. Salluh, MD, PhD 5 et al 2025년 10월 29일 JAMA Published Online: October 29, 2025 DOI: 10.1001/jama.2025.20516 Abstract Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture current c
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7일 전3분 분량


Multiparametric Assays for Accelerating Early Drug Discovery
Alexander Herholt 1 2 , Sabrina Galinski 1 2 , Philipp E. Geyer 3 4 5 , Moritz J. Rossner 1 , Michael C. Wehr 1 2 https://doi.org/10.1016/j.tips.2020.02.005 Trends in pharmacological science Volume 41, Issue 5 , May 2020, Pages 318-33 영문 초록 Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where i
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7일 전3분 분량


Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice.
Wenzheng Zou, Yuqing Lv, Zux iang Liu, Pengyan Xia, Hong Li & Jianwei Jiao Scientific reports, 24 July 2020 http://doi.org/10.1038/s41598-020-69447-4 Abstract: Hydrocephalus is a brain disorder triggered by cerebrospinal fluid accumulation in brain cavities. Even though cerebrospinal fluid flow is known to be driven by the orchestrated beating of the bundled motile cilia of ependymal cells, little is known about the mechanism of ciliary motility. RSPH9 is increasingly becomin
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10월 22일2분 분량


Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.
Gao, Baocheng, Wang, Haoxiang, Hu, Shuang, Zhong, Kunhong, Liu, Xiaoyin1, Deng, Ziang1, Li, Yuanyou1, Tong, Aiping4, Zhou, Liangxue Neural Regeneration Research, April 30, 2025 https://doi.org/10.4103/NRR.NRR-D-24-01491 Abstract (영문) Neural stem cells (NSCs) possess self-renewal and multipotent differentiation capabilities, offering potential for treating neurological diseases. However, their survival rate after transplantation in ischemic and hypoxic environments such as p
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10월 22일3분 분량


Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Hoogstrate et al Cancer Cell , 2023 https://doi.org/10.1016/j.ccell.2023.02.019 Summary A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an interconnected continuum in a two-dimensional spac
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10월 16일3분 분량


ChemBounce: a computational framework for scaffold hopping in drug discovery
Woo Dae Jang, Changdai Gu, Yumi Noh, Kwang-Seok, Jae Yong Ryu https://doi.org/10.1093/bioinformatics/btaf501 Scaffold hopping is a critical strategy in medicinal chemistry for generating novel and patentable drug candidates. Here, we present ChemBounce, a computational framework designed to facilitate scaffold hopping by generating structurally diverse scaffolds with high synthetic accessibility. Given a user-supplied molecule in SMILES format, ChemBounce identifies the core
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10월 16일3분 분량


Primary brain tumours in adults
Prof Martin J van den Bent, MD a m.vandenbent@erasmusmc.nl ∙ Marjolein Geurts, MD a ∙ Pim J French, PhD a ∙ ...
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10월 13일3분 분량


Topoisomerase Regulation of Cancer Gene Expression
Laura Baranello 1,* , Fedor Kouzine 2,* and David Levens 2,* https://doi.org/10.1146/annurev-biochem-091724-010717 , Annual Review of...
한울 전
10월 10일4분 분량


Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria
The VasCog-2-WSO Criteria Consortium 2025년09월16일 JAMA Neurol . Published online: September 16, 2025. Doi: 10.1001/jamaneurol.2025.3242...
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9월 30일2분 분량


Activation of the RARα attenuated CSF hypersecretion to inhibit hydrocephalus development via regulating the MAFB/MSR1 pathway
Hanhai Zeng, Kaibo Yu, Junyou Wang, Jingya Ye, Huaijun Chen, Chaoran Xu, Ting Chen, Feng Yan, Gao Chen and Chi Gu 출처 및 게재 (발행일):...
김소영
9월 29일2분 분량


Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Aziz Taghbalout 1,6 ∙ Chia-Hao Tung 1,6 ∙ Patricia A. Clow 2 ∙ Harianto Tjong 2 ∙ Ping Wang 2,5 ∙ Chee Hong Wong 1 ∙ Diane...
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9월 29일2분 분량


A Randomized Trial of Shunting for Idiopathic Normal-Pressure Hydrocephalus
Mark G. Luciano, M.D., Ph.D. et al. 2025년 9월 16일 N Engl J Med DOI: 10.1056/NEJMoa2503109 Abstract Background Idiopathic...
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9월 29일3분 분량


Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.
Qiguang Wang, Fei Liu, Yue Li, Huan Zhang, Xin Qi, Ke Wu, Yi Zhang, Shenglan You, Wenke Liu, Xuhui Hui, Hanmei Li, Lei Zhu, Huile Gao,...
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9월 29일2분 분량


Pharmacogenomics of GPCR Drug Targets
Alexander S. Hauser, Sreenivas Chavali, Ikuo Masuho, Leonie J. Jahn, Kirill A. Martemyanov, David E. Gloriam, M. Madan Babu 11 January...
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9월 23일3분 분량


White Matter Tract Density Index Prediction Model of Overall Survival in Glioblastoma
Alessandro Salvalaggio, MD, PhD 1,2 ; Lorenzo Pini, PhD 1,2 ; Matteo Gaiola, MD 1 et al JAMANeurol.2023;80(11):1222-1231.doi:10.1001/j...
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9월 22일3분 분량


Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul...
한울 전
9월 16일3분 분량







