

Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers
Yael Rosen-Lang, MPH1; Agathe Vrillon, MD, PhD2,3; Shlomit Pasternak, MSc1 et al 2026년 06월 29일 JAMA Published Online: June 29, 2026 DOI: 10.1001/jamaneurol.2026.2042 Abstract Importance Traumatic brain injury (TBI) is a risk factor for dementia and is known to impact levels of several Alzheimer disease (AD) blood biomarkers. The plasma phosphorylated tau 217 (p-tau217)/amyloid-β 42 (Aβ42) ratio has been reported to be 90% accurate for the detection of brain amyloid in civili
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2일 전4분 분량


Three Low-Dose Antihypertensive Agents in a Single Pill after Intracerebral Hemorrhage
Craig S. Anderson, MBBS, PhD. et al. 2026년 4월 22일 N Engl J Med 2026;394:1571-1582 DOI: 10.1056/NEJMoa2515043 Abstract Background Blood-pressure reduction is the only proven treatment to prevent stroke due to intracerebral hemorrhage. Whether a single pill that combines three antihypertensive drugs at low doses, in addition to standard antihypertensive treatment, can lower blood pressure more than standard care alone and reduce the risk of recurrent stroke after intracereb
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6월 29일3분 분량
Artificial intelligence-based MRI radiomics and radiogenomics in glioma
Haiqing Fan # 1, Yilin Luo # 1, Fang Gu 1, Bin Tian 1, Yongqin Xiong 1, Guipeng Wu 1, Xin Nie 1, Jing Yu 1, Juan Tong 1, Xin Liao 2 Affiliations Expand · PMID: 38486342 · PMCID: PMC10938723 · DOI: 10.1186/s40644-024-00682-y Abstract The specific genetic subtypes that gliomas exhibit result in variable clinical courses and the need to involve multidisciplinary teams of neurologists, epileptologists, neurooncologists and neurosurgeons. Currently, the dia
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6월 22일2분 분량


Endovascular Treatment of Medium-Vessel-Occlusion Strokes
Wei Hu, M.D et al. 2026년5월 13일 N Engl J Med 2016;394:1894-1904. DOI: 10.1056/NEJMoa2514120 Abstract Background Endovascular thrombectomy for acute ischemic stroke due to medium-vessel occlusion has had varying results across trials. Whether thrombectomy improves functional outcomes in patients with medium-vessel occlusion and moderate-to-severe deficits is unclear. Methods We conducted an open-label, randomized trial with blinded outcome assessment at 48 centers in China.
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6월 15일3분 분량


The glymphatic system and glioblastoma
Andrea Soumbasis 1,2, Aito Ueno 3,4,5,6, David Elliott 7,8,9, Sanju Lama 10,11,12,13, Sarah Edwards 14, Yves P Starreveld 15,16, Yunyan Zhang 17,18,19,20, Paolo Federico 21,22,23,24, Garnette R Sutherland 25,26,27,28, Pierre LeVan 29,30,31,32,33, Candice C Poon 34,35,36,37,38,39,✉ Brain. 2025 Nov 28;149(5):1485–1497. doi: 10.1093/brain/awaf449 Abstract The discovery of the glymphatic system and meningeal lymphatic vessels revolutionized the understanding of brain waste cleara
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6월 1일2분 분량


Embolization of the Middle Meningeal Artery for Chronic Subdural Hematoma
David Fiorella, M.D., Ph.D. et al. 2024년 11월 20일 N Engl J Med 2025;392:855-864 DOI: 10.1056/NEJMoa2409845 Abstract Background Patients receiving standard treatment for chronic subdural hematoma have a high risk of treatment failure. The effect of adjunctive middle meningeal artery embolization on the risk of treatment failure in this population remains unknown. Methods We randomly assigned patients with symptomatic chronic subdural hematoma to undergo middle meningeal art
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5월 27일3분 분량


Peritumoral Edema in Gliomas: A Review of Mechanisms and Management
Kazufumi Ohmura 1,2 , Hiroyuki Tomita 1,3,* and Akira Hara 1 Biomedicines 2023, 11(10), 2731; https://doi.org/10.3390/biomedicines11102731 Submission received: 31 July 2023 / Revised: 29 September 2023 / Accepted: 6 October 2023 / Published: 9 October 2023 (This article belongs to the Special Issue Gliomas: Signaling Pathways, Molecular Mechanisms and Therapeutic Approaches) Abstract: Treating malignant glioma is challenging owing to its highly invasive potential in he
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5월 19일2분 분량


Management of Chronic Subdural Hematoma With Adjunctive Embolization of Middle Meningeal Artery The EMMA-Can Randomized Clinical Trial
Jai Jai Shiva Shankar, MD, DM, MSc1,2,3; Susan Alcock, MN1; Nima Kashani, MD1et al 2026년04월30일 JAMA Neurol. Published online: April 30, 2026. DOI:10.1001/jamaneurol.2026.4910 Importance Chronic subdural hematomas commonly recur after surgical drainage. The effect of adjunctive embolization of the middle meningeal artery (EMMA) on recurrence risk remains unclear. Objective To evaluate whether EMMA as an adjunct to surgical drainage reduces chronic subdural hematoma recurrenc
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5월 8일3분 분량


Acute Brain Injury in New-Onset Refractory Status Epilepticus and Etiology-Defined Status Epilepticus
Stefano Meletti, MD, PhD1,2; Aurelie Hanin, PhD3,4; Giada Giovannini, MD, PhD1 et al 2026년04월27일 JAMA Neurol. Published online: April 27, 2026. DOI:10.1001/jamaneurol.2026.0865 Abstract Importance Seizure-induced brain injury is central to the treatment urgency of new-onset refractory status epilepticus (NORSE). Identifying biomarkers that reflect ongoing neuronal damage could inform therapeutic timing and improve outcomes. Objective To quantify acute brain injury in pati
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4월 28일4분 분량


Tumor microenvironment in glioblastoma: Current and emerging concepts
Pratibha Sharma , Ashley Aaroe, Jiyong Liang, and Vinay K. Puduvalli Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (P.S., A.A., J.L., V.K.P.) Corresponding Author: Vinay K. Puduvalli, MD, 1515 Holcombe Blvd, Unit 431, Houston, TX 77030, USA (vpuduval@mdanderson. org). Neuro-Oncology Advances 5(1), 1–16, 2023 | https://doi.org/10.1093/noajnl/vdad009 | Advance Access date 23 February 2023 Glioblastoma (GBM) tumor microenvir
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4월 27일2분 분량


Long-Term Mortality, Cognition, and Quality of Life After Chronic Subdural Hematoma Surgery
Thomas Petutschnigg, MD1 ; Samuel Aschwanden1 ; Claire Descombes, MSc1 et al 2026년 04월13일 JAMA Neurol . Published online: April 13, 2026. Doi: 10.1001/jamaneurol.2026.0656 Abstract Importance Chronic subdural hematoma (cSDH) is among the most common neurosurgical disorders in older adults. Although short-term outcomes after surgery are favorable, long-term survival and health-related quality of life (HRQoL) remain poorly characterized. Objectives To evaluate long-t
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4월 20일4분 분량


Monro-Kellie 4.0: moving from intracranial pressure to intracranial dynamics
Sérgio Brasil1*, Gustavo C. Patriota2 , Daniel Agustín Godoy3 , Jorge L. Paranhos4 , Andrés Mariano Rubiano5 and Wellingson S. Paiva Crit Care. 2025 Jun 5;29:229. doi: 10.1186/s13054-025-05476-7 Abstract The Monro-Kellie doctrine, introduced in the late 18th century, was a groundbreaking concept aimed at explaining the interactions between intracranial volume components. It has since become a cornerstone of brain physiology, now recognized as intracranial dynamics. Initial
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4월 7일2분 분량


Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2026
Prescott, Hallie C. MD, MSc 1,2 ; Antonelli, Massimo MD 3,4 ; Alhazzani, Waleed MD, MSc, FRCPC 5,6,7 ; Møller, Morten Hylander MD, PhD 8,9 ; Alshamsi, Fayez MBBS 10 ; Azevedo, Luciano C. P. MD, PhD 11 ; Belley-Cote, Emilie MD, PhD 12,13,14 ; De Waele, Jan MD, PhD 15,16 ; Derde, Lennie MD, PhD 17,18 ; Dionne, Joanna C. MD, MSc, PhD, FRCPC 19,20 ; Evans, Laura MD 21 ; Gershengorn, Hayley B. MD 22,23 ; Hodgson, Carol L. PhD, PT, MPhils, PGDip(Crit Care) 24,25 ; Honarmand, Kimia
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3월 24일3분 분량


Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy
Emanuele Cerulli Irelli, MD, PhD1 ; Roberta Roberti, MD2 ; Maria Sole Borioni, MD1 et al 2026년 02월09일 JAMA Neurol . Published online: February 9, 2026 DOI:10.1001/jamaneurol.2025.5625 Abstract Importance Treatment decisions in drug-resistant focal epilepsy remain largely empirical, as direct comparative evidence among newer antiseizure medications (ASMs) is limited. Real-world data can complement randomized clinical trials by providing insights into long-term effectiv
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3월 23일4분 분량


High-throughput identification of repurposable neuroactive drugs with potent anti-glioblastoma activity
Sohyon Lee , Tobias Weiss , Marcel Bühler , Julien Mena , Zuzanna Lottenbach , Rebekka Wegmann , Miaomiao Sun , Michel Bihl , Bartłomiej Augustynek , Sven P. Baumann , Sandra Goetze , Audrey van Drogen , Patrick G. A. Pedrioli , David Penton , Yasmin Festl , Alicia Buck , Daniel Kirschenbaum , Anna M. Zeitlberger , Marian C. Neidert , Flavio Vasella , Elisabeth J. Rushing , Bernd Wollscheid , Matthias A. Hediger , Michael Weller & Berend Snijder ...
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3월 17일3분 분량


A new characterisation of acute traumatic brain injury: the NIH-NINDS TBI Classification and Nomenclature Initiative
Prof Geoffrey T Manley MD a , Prof Kristen Dams-O’Connor PhD b * , Michael L Alosco PhD c , Hibah O Awwad PhD d, Prof Jeffery J Bazarian MD e , Prof Peter Bragge BPhysio f , Prof John D Corrigan PhD g , Adele Doperalski PhD d, Prof Adam R Ferguson PhD a h , Prof Christine L Mac Donald PhD i , Prof David K Menon MD j , Prof Molly M McNett PhD k , Prof Joukje van der Naalt MD l , Prof Lindsay D Nelson PhD m , Dana Pisică MD n, Prof Noah D Silverberg PhD o...
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3월 9일2분 분량


One-Year Outcomes After Traumatic Brain Injury and Early Extracranial Surgery in the TRACK-TBI Study
Christopher J. Roberts, MD, PhD1,2 ; Amelia W. Maiga, MD, MPH3,4,5 ; Jason Barber, MS6 ; et al 2025년10월 10일 JAMA Netw Open Published Online: October 10, 2025 DOI: 10.1001/jamanetworkopen.2025.372271 Abstract Importance Exposure to extracranial (EC) surgery early after traumatic brain injury (TBI) is associated with cognitive risks. Objective To examine whether exposure to EC surgery during a TBI index admission is associated with worse outcomes at 1 year compared with n
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3월 4일4분 분량
The Next Era of Idiopathic Normal Pressure Hydrocephalus
Michael A. Williams, MD1 ; Mark G. Luciano, MD, PhD2 ; Jan Malm, MD, PhD3 et al 2026년02월06일 JAMA Neurol . Published online: February 2, 2026. Doi: 10.1001/jamaneurol.2025.5412 1965년 정상압 수두증(NPH)이 치료 가능한 치매의 한 형태 로 처음 기술된 이후, NPH에 대한 열광과 기대의 시대가 시작되었다. 당시에는 치매에 대한 치료가 거의 없었거나 상상조차 어려웠다. 곧 많은 치매 환자들이 방사성 동위원소 cisternography나 pneumo-encephalography를 기반으로 NPH로 진단받고 션트 수술을 받게 되었다. 초기에는 긍정적인 보고들이 쏟아졌지만, 이후 연구 결과에서는 점차 좋지 않은 결과들이 나타나기 시작했다. 1992년에 발표된 정상압 수두증에서 션트 수술의 이익이 위험
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2월 20일3분 분량


Glioblastoma at the crossroads: current understanding and future therapeutic horizons
Shilpi Singh , Devanjan Dey , Debashis Barik , Iteeshree Mohapatra , Stefan Kim , Mayur Sharma , Sujata Prasad , Peize Wang , Amar Singh and Gatikrushna Singh Glioblastoma (GBM) remains the most aggressive and lethal brain tumor in adults and poses significant challenges to patient survival. This review provides a comprehensive exploration of the molecular and genetic landscape of GBM, focusing on key oncogenic drivers, such as epidermal growth factor receptor (EGFR), platelet
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2월 19일3분 분량


Emerging Therapies for Glioblastoma
AlissaA.Thomas,MD;CameronW.Brennan,MD;LisaM.DeAngelis,MD;AntonioM.Omuro,MD IMPORTANCE Glioblastoma is the most common primary malignant brain tumor, but despite multimodal treatment with surgery, radiotherapy, and temozolomide chemotherapy, the prognosis is poor, with a median survival of 16 to 19 months and poor quality of life throughout the disease course. New treatments are needed. EVIDENCE REVIEW Articles were identified through a search of PubMed references from March
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1월 26일2분 분량




