

Targeting TRIM25 as a therapeutic strategy to enhance ferroptosis in glioblastoma cells
1.논문 제목: Targeting TRIM25 as a therapeutic strategy to enhance ferroptosis in glioblastoma cells 2.저자명: Maorong Zhu, Yuxin Wu, Huihui Ou, Xiao Liu, Yawen Wang, Xiaolin Liu, Cheng Zou, Guangzhao Yang, Mingrui Du, Duo Yu, Dan Zheng, Lei He, Kuo Zhang, Wangqian Zhang, Shuning Wang, Haozhe Qin, Qiang Hao, Yalong He, Wei Lin, Yingqi Zhang, Jintao Gu, Meng Li, Weidong Qin, Zhengcong Cao 3.Publish: Journal of Nanobiotechnology, 2026 4.DOI: https://doi.org/10.1186/s12951-025-03908-8
김영혜
1일 전2분 분량


ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries
1.논문 제목: ADMET-AI: a machine learning ADMET platform for evaluation of large-scale chemical libraries 2.저자명: Kyle Swanson, Parker Walther, Jeremy Leitz, Souhrid Mukherjee, Joseph C. Wu, Rabindra V. Shivnaraine, James Zou 3.Publish: 2024 Jul 01 4.DOI: 10.1093/bioinformatics/btae416 5.Abstract: The emergence of large chemical repositories and combinatorial chemical spaces, coupled with high-throughput docking and generative AI, have greatly expanded the chemical diversity of sm
임지현
11월 3일3분 분량


Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis
1.논문 제목: Biomimetic Nanoplatform for Targeted Glioblastoma Therapy via Concurrently Triggering GPX4/DHODH Mediated Ferroptosis 2.저자명: Guodong Ren, Xuewei Wang, Panpan Li, Hao Wu, Zhifei Bi, Qi Gao, Bolong Ma, Zixuan Tian, Jianfei Liu, Fuqiang Feng, Wen Liu, Lin Li, Chengwu Zhang 3.Publish: Advanced Science, 2026 4.DOI: https://doi.org/10.1002/advs.202521236 5.Abstract: Glioblastoma (GBM) is a highly aggressive brain tumor with limited therapeutic options. This study developed
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11월 2일2분 분량


A bioavailable GPX4 inhibitor for ferroptosis induction in vivo and tumor suppression
Nathchar Naowarojna, Xin Gu, Zijian Pan, Tao Peng, Yikai Wang , Yilong Zou, 2026, Cell 189, 1–15 https://www.cell.com/cell/fulltext/S0092-8674(26)01200-6 초록 Ferroptosis is implicated in multiple human diseases, but the lack of bioavailable inducers has limited its physiological study and therapeutic translation. Here, we report KY0418, a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) featuring an isourea warhead, with high plasma stability and broad tissue
한울 전
10월 25일4분 분량


Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes
1.논문 제목 : Targeted Ferroptosis-Immunotherapy Synergy: Enhanced Antiglioma Efficacy with Hybrid Nanovesicles Comprising NK Cell-Derived Exosomes and RSL3-Loaded Liposomes 2.저자명: Wenyan Hao, Nan Sun, Yueyue Fan, Mengyu Chen, Qianqian Liu, Meiyan Yang, Yang Yang, Chunsheng Gao, 3.Publish: 22 May 2024 4.DOI: https://doi.org/10.1021/acsami.4c04604 5.Abstract: Glioblastoma is a highly aggressive brain tumor that remains difficult to treat, highlighting the need for effective drug d
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10월 19일3분 분량


Degrading GPX4 via Biomimetic Nanoparticle-Mediated InSitu Synthesis of Deep-Learning-Designed Binder-DegronChimeras for Prostate Cancer Therapy
Si-Han Zhang, Ye An, Na Zeng, Mei-Cheng Liu, Jian-Xuan Sun, Xi Gong, Jin-Zhou Xu, Shao-Gang Wang, Qi-Dong Xia Adv Sci (Weinh) . 2026 Sep 27:e77932 Abstract Glutathione peroxidase 4 (GPX4) is a central guardian against ferroptosis and a critical therapeutic target for castration-resistant prostate cancer (CRPC). However, traditional GPX4 inhibitors are often limited by irreversible covalent binding and systemic toxicity. Here, we utilized the deep learning algorithm Bindcraft
한울 전
10월 12일4분 분량


Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy
1.논문 제목: Molecular docking and dynamics reveal novel CDK6 inhibitors for targeted glioblastoma therapy. 2.저자명: Muhammad Umer Khan, Maha Munir, Hina Manzoor, Ismail Hamad, Tahir Ali Chohan, Badriyah S Alotaibi 3.Publish: 13 February 2026 4.DOI: https://doi.org/10.1038/s41598-026-39629-7 5.Abstract: Glioblastoma multiform (GBM) is the most deadly type of primary CNS tumor and is linked to dysregulation of the CDK4/6 pathway, poor prognosis, and high rate of post-surgical recurr
임지현
10월 12일4분 분량


Ferroptosis resistance-related TEP1 as a novel prognostic biomarker involved in immune cell infiltration and tumour progression in glioblastoma
1. 논문 제목: Ferroptosis resistance-related TEP1 as a novel prognostic biomarker involved in immune cell infiltration and tumour progression in glioblastoma 2. 저자명: Kunxiang Chen, Chengzong Zhong, Yiqing Wang, Tao Liu, Huan Chen, Ruizhi Wu, Guanping Qiu, Siqi Zheng, Yong Gao, Yuean Ping, Qiang Zhou, Yuntao Lu and Hong Li 3. 출처 및 게재 (발행일): Cancer Cell International, 3 December 2025 4. DOI: https://doi.org/10.1186/s12935-025-04114-0 5. Abstract: 5-1 Background: TEP1 is a ribonucl
김소영
9월 28일3분 분량


Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme
1.논문 제목: Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme 2.저자명: Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Alfredo Quinones-Hinojosa, Debabrata Mukhopadhyay 3.Publish: Communications
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9월 28일3분 분량


REINVENT 4: Modern AI-driven generative molecule design
1.논문 제목: REINVENT 4: Modern AI-driven generative molecule design 2.저자명: Hannes H. Loeffler, Jiazhen He, Alessandro Tibo, Jon Paul Janet, Alexey Voronov, Lewis H. Mervin, Ola Engkvist 3.Publiush: 21 February 2024 4.DOI: https://doi.org/10.1186/s13321-024-00812-5 5.Abstract: REINVENT 4 is a modern open-source generative AI framework for the design of small molecules. The software utilizes recurrent neural networks and transformer architectures to drive molecule generation. Thes
임지현
9월 21일3분 분량


Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
1. 논문 제목: Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect. 2. 저자명: Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng and Aimin Li 3. 출처 및 게재 (발행일): Journal of Nanobiotechnology, 23 December 2021 4. DOI: https://doi.org/10.1186/s12951-021-01180-0 5. Abstract: The integrin αvβ3 receptor and Lactoferrin receptor (LfR) are over-expressed in both cerebral microvascular
김소영
9월 8일3분 분량


Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy
1.논문 제목: Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy 2.저자명: Boyan Li, Xin Chen, J. Dong, S. Zhang, W. Qin, R. Zhang, Z. Peng, S. Zhang, Q. Guo, Y. Qin, W. Wang, L. Deng, S. Nie, Y. Sun, H. Xu, H. Li, G. Liu 3.Publish: Advanced Science, 2022 4.DOI: 10.1002/advs.202105451 5.Abstract: GBM은 높은 악성도와 BBB로 인해 약물이 종양에 효과적으로 전달되기 어렵다. 또한 페롭토시스를 이용한 치료에서도 암세포가 여러 방어기전을 통해 페롭토시스를 회피할 수 있다. 본 연구에
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9월 8일3분 분량


Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer
1.논문 제목: Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer 2.저자명: Congjun Xu, Zhanghong Xiao, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, Chunshun Zhao 3.Publish: September 10, 2021 4.DOI: https://doi.org/10.1021/acs.jmedchem.1c00569 5.Abstract: Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptos
임지현
9월 1일3분 분량


Posttranslational modifications remodel proteome-wide ligandability
Li, W., Wei, Q., Llanos, M. et al. Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02216-y Posttranslational modifications (PTMs) vastly expand the diversity of the human proteome, dynamically reshaping protein activity, interactions and localization in response to environmental, pharmacologic and disease-associated cues. However, their proteome-wide impact on small-molecule recognition—and, thus, druggability—remains largely unexplored. Here we present a chemical pr
한울 전
8월 24일3분 분량


Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment
1.논문 제목: Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment 2.저자명: Zahra Abousalman-Rezvani, Ahmed Refaat, Pouya Dehghankelishadi, Hossein Roghani-Mamaqani, Lars Esser, and Nicolas H. Voelcker 3. 출처 및 게재 : Advanced Healthcare Materials, 7 March 2024 4. DOI: https://doi.org/10.1002/adhm.202302902 5. Abstract: Brain cancers, especially glioblastoma multiforme, are associated with poor prognosis due to the limited efficacy of current therapies
김소영
8월 18일3분 분량


Preparation and application of pH-responsive drug delivery systems
1.논문 제목: Preparation and application of pH-responsive drug delivery systems 2.저자명: Haitao Ding, Ping Tan, Shiqin Fu, Xiaohe Tian, Hu Zhang, Xuelei Ma, Zhongwei Gu, Kui Luo. 3.출처 및 게재일: Journal of Controlled Release, 2022 4.DOI: 10.1016/j.jconrel.2022.05.056 5.Abstract: pH-responsive drug delivery systems are designed to exploit differences in pH between normal and pathological tissues to achieve controlled and site-specific drug release. Because tumors, inflammatory tissues,
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8월 18일4분 분량


Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
1.논문 제목: Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells 2.저자명: Shengjie Peng, Guodong Chen, K. N. Yu, Yue Feng, Lele Zhao, Miaomiao Yang, Wei Cao, Waleed Abdelbagi Ahmed Almahi, Mingyu Sun, Yuan Xu, Ye Zhao, Cheng Cheng, Fengqin Zhu, Wei Han. 3.Publish: 12 February 2024 4.DOI: 10.1186/s12964-023-01382-z 5.Abstract: Though (1S, 3R)-RSL3 has been used widely
임지현
8월 10일5분 분량


Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Governa et al., Proceedings of the National Academy of Sciences, 2022 DOI: 10.1073/pnas.2114456119 Therapeutic strategies directed at the tumor surfaceome (TS),including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have deve
한울 전
8월 10일5분 분량


Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain
1. 논문 제목: Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain 2. 저자명: Fei-Cheng Yang, Chuan Wang, Jiang Zhu, Qu-Jing Gai, Min Mao, Jiang He, Yan Qin, Xiao-Xue Yao, Yan-Xia Wang, Hui-Min Lu, Mian-Fu Cao, Ming-Min He, Xian-Mei Wen, Ping Leng, Xiong-Wei Cai, Xiao-Hong Yao, Xiu-Wu Bian and Yan Wang 3. 출처 및 게재 (발행일): Laboratory Investigation, 25 Feb
김소영
8월 3일3분 분량


Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
1.논문 제목: Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. 2.저자명: Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent Stockwell, Guido Kroemer, Rui Kang, Daolin Tang. 3.Publish: Science Translational Medicine, 1 November, 2023 4.DOI: 10.1126/scitranslmed.adg3049 5.Abstract: Current ferroptosis inducers effectively kill cancer cells by inhibiting GPX4 but also damage immune cells,
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8월 3일3분 분량




