

Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar
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2일 전2분 분량


The Blood−Brain Barrier (BBB) Score
Mayuri Gupta, Hyeok Jun Lee, Christopher J. Barden, and Donald F. Weaver 10.1021/acs.jmedchem.9b01220 Abstract The blood−brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations. Understanding the BBB interaction with drug molecules based on physicochemical property space can guide effective and efficient d
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3일 전3분 분량


Multiparametric Assays for Accelerating Early Drug Discovery
Alexander Herholt 1 2 , Sabrina Galinski 1 2 , Philipp E. Geyer 3 4 5 , Moritz J. Rossner 1 , Michael C. Wehr 1 2 https://doi.org/10.1016/j.tips.2020.02.005 Trends in pharmacological science Volume 41, Issue 5 , May 2020, Pages 318-33 영문 초록 Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where i
한울 전
7일 전3분 분량


Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice.
Wenzheng Zou, Yuqing Lv, Zux iang Liu, Pengyan Xia, Hong Li & Jianwei Jiao Scientific reports, 24 July 2020 http://doi.org/10.1038/s41598-020-69447-4 Abstract: Hydrocephalus is a brain disorder triggered by cerebrospinal fluid accumulation in brain cavities. Even though cerebrospinal fluid flow is known to be driven by the orchestrated beating of the bundled motile cilia of ependymal cells, little is known about the mechanism of ciliary motility. RSPH9 is increasingly becomin
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10월 22일2분 분량


Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.
Gao, Baocheng, Wang, Haoxiang, Hu, Shuang, Zhong, Kunhong, Liu, Xiaoyin1, Deng, Ziang1, Li, Yuanyou1, Tong, Aiping4, Zhou, Liangxue Neural Regeneration Research, April 30, 2025 https://doi.org/10.4103/NRR.NRR-D-24-01491 Abstract (영문) Neural stem cells (NSCs) possess self-renewal and multipotent differentiation capabilities, offering potential for treating neurological diseases. However, their survival rate after transplantation in ischemic and hypoxic environments such as p
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10월 22일3분 분량


Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Hoogstrate et al Cancer Cell , 2023 https://doi.org/10.1016/j.ccell.2023.02.019 Summary A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an interconnected continuum in a two-dimensional spac
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10월 16일3분 분량


ChemBounce: a computational framework for scaffold hopping in drug discovery
Woo Dae Jang, Changdai Gu, Yumi Noh, Kwang-Seok, Jae Yong Ryu https://doi.org/10.1093/bioinformatics/btaf501 Scaffold hopping is a critical strategy in medicinal chemistry for generating novel and patentable drug candidates. Here, we present ChemBounce, a computational framework designed to facilitate scaffold hopping by generating structurally diverse scaffolds with high synthetic accessibility. Given a user-supplied molecule in SMILES format, ChemBounce identifies the core
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10월 16일3분 분량


Topoisomerase Regulation of Cancer Gene Expression
Laura Baranello 1,* , Fedor Kouzine 2,* and David Levens 2,* https://doi.org/10.1146/annurev-biochem-091724-010717 , Annual Review of...
한울 전
10월 10일4분 분량


Activation of the RARα attenuated CSF hypersecretion to inhibit hydrocephalus development via regulating the MAFB/MSR1 pathway
Hanhai Zeng, Kaibo Yu, Junyou Wang, Jingya Ye, Huaijun Chen, Chaoran Xu, Ting Chen, Feng Yan, Gao Chen and Chi Gu 출처 및 게재 (발행일):...
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9월 29일2분 분량


Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Aziz Taghbalout 1,6 ∙ Chia-Hao Tung 1,6 ∙ Patricia A. Clow 2 ∙ Harianto Tjong 2 ∙ Ping Wang 2,5 ∙ Chee Hong Wong 1 ∙ Diane...
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9월 29일2분 분량


Choroid plexus CCL2‒CCR2 signaling orchestrates macrophage recruitment and cerebrospinal fluid hypersecretion in hydrocephalus.
Qiguang Wang, Fei Liu, Yue Li, Huan Zhang, Xin Qi, Ke Wu, Yi Zhang, Shenglan You, Wenke Liu, Xuhui Hui, Hanmei Li, Lei Zhu, Huile Gao,...
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9월 29일2분 분량


Pharmacogenomics of GPCR Drug Targets
Alexander S. Hauser, Sreenivas Chavali, Ikuo Masuho, Leonie J. Jahn, Kirill A. Martemyanov, David E. Gloriam, M. Madan Babu 11 January...
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9월 23일3분 분량


Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul...
한울 전
9월 16일3분 분량


Brain tumoroids: Treatment prediction and drug development for brain tumors with fast, reproducible, and easy-to-use personalized models
Aurélie Soubéran, Carine Jiguet-Jiglaire, SolineToutain, Philippe Morando, Nathalie Baeza-Kallee , Romain Appay, Céline Boucard, Thomas...
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9월 11일2분 분량


Choroid plexus mast cells drive tumor-associated hydrocephalus
Yiye Li, Can Di, Shijian Song, Yubo Zhang, Yiwen Lu, Jianyou Liao, Bingxi Lei, Jian Zhong, Kaihua Guo, Nu Zhang, and Shicheng Su Cell...
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9월 8일2분 분량


Cerebrospinal fluid markers of neuroinflammation and coagulation in severe cerebral edema and chronic hydrocephalus after subarachnoid hemorrhage: a prospective study
Yuanjian Fang, Yibo Liu, Luxi Chen, Junjie Wang, Jiahao Zhang, Haocheng Zhang, Sixuan Tian, Anke Zhang, Jianmin Zhang, John H. Zhang,...
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9월 8일3분 분량


Recent Scaffold Hopping Applications in Central Nervous System Drug Discovery
Timothy B. Callis, Taylor R. Garrett, Andrew P. Montgomery, Jonathan J. Danon, Michael Kassiou* 10.1021/acs.jmedchem.2c00969 abstract The...
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9월 3일3분 분량


Effective targeting of PDGFRA-altered high-grade glioma with avapritinib
Lisa Mayr, Sina Neyazi, Kallen Schwark, ..., Carl Koschmann, Johannes Gojo, Mariella G. Filbin Cancer Cell. 2025 Apr 14;43(4):740-756.e8...
한울 전
9월 3일3분 분량


Neutrophil extracellular trap-mediated impairment of meningeal lymphatic drainage exacerbates secondary hydrocephalus after intraventricular hemorrhage
Qiang Zhang, Yujie Chen, Yingpei Li, Zhou Feng, Liang Liang, Xiaoke Hao, Wenbo Kang, Zhaoqi Zhang, Xuyang Zhang, Rong Hu, Hua Feng, Zhi...
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8월 18일2분 분량


Inhibition of histone deacetylase 6 activity mitigates neurological impairment and post-hemorrhagic hydrocephalus after intraventricular hemorrhage by modulating pyroptosis and autophagy pathways.
Hao-Xiang Wang, Zi-Ang Deng, Yuan-You Li, Jun Li, Ya-Xing Chen, Yan-Jie Zhao, Ke-Ru Huang, Wei- Ning Tian, Ai-Ping Tong, and...
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8월 18일2분 분량







