

Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutantGBM to AZD1390-mediated radiosensitization.
논문 제목 : Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. 저자명 : Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Ashwin Bale, Brett L. Carlson, Kendra A. Porath, Katrina K. Bakken, Danielle M. Burgenske, Paul A. Decker, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan Harley, William F. Elmquist, Zachary D. Nagel, Shiv K. Gupta, Jann N. Sarkaria.
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3일 전3분 분량


Virtual Screening Directly Identifies New Fragment-Sized Inhibitorsof Carboxylesterase Notum with Nanomolar Activity
논문 제목 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity 저자명 David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish,* and Fredrik Svensson Publish 2022 Jan 13 DOI https://doi.org/10.1021/acs.jmedchem.1c01735 Abstract Notum is a negative regulator of Wnt signalin
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3일 전4분 분량


Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM.
논문 제목 Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM. 저자명 Jorge L. Jimenez-Macias, Philippa Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan Forrest, Jason Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William Hawkins, Noe Mercado, Jacqueline Real, Kelsey Huntington, Mykola Zdioruk, Michal O. Nowicki, Choi-Fong Cho, Bin Wu, Weiyi Li, Theresa Logan, Katherine E. Manz, Kurt D. Pennell, Bogda
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3일 전3분 분량


Glioblastoma remodeling of human neural circuits decreases survival.
1. 논문 제목: Glioblastoma remodeling of human neural circuits decreases survival. 2. 저자명: Saritha Krishna, Abrar Choudhury, Michael B. Keough, Kyounghee Seo, Lijun Ni, Sofia Kakaizada, Anthony Lee, Alexander Aabedi, Galina Popova, Benjamin Lipkin, Caroline Cao, Cesar Nava Gonzales, Rasika Sudharshan, Andrew Egladyous, Nyle Almeida, Yalan Zhang, Annette M. Molinaro, Humsa S. Venkatesh, Andy G. S. Daniel, Kiarash Shamardani, Jeanette Hyer, Edward F. Chang, Anne Findlay, Joanna
김소영
3일 전2분 분량


Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus
1. 논문 제목: Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus 2. 저자명: Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao,
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12월 15일2분 분량


Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
D Azorín D, Hoffmann DC, Hebach NR, Jung E, Hausmann D, Ratliff M, Hai L, Horschitz S, Jabali A, Osswald M, Karreman MA, Kessler T, Wendler S, Mayer CD, Löb C, Lehnert P, Cebulla G, Reibold D, Khajuria RK, Bordignon P, Moor AE, Holland-Letz T, Reckless J, Ramsden N, Grainger D, Kreshuk A, Koch P, Wick W, Heuer S, Winkler F. Cancer Discovery. 2025 Oct 9. doi: 10.1158/2159-8290.CD-24-0414 영문초록 Glioblastomas are incurable primary brain tumors that depend on neural-like cellula
한울 전
12월 11일3분 분량


AI-Powered Virtual Screening of Large Compound Libraries Leads to the Discovery of Novel Inhibitors of Sirtuin-1
Anastasiia Gryniukova, Florian Kaiser, Iryna Myziuk, Diana Alieksieieva, Christoph Leberecht, Peter P. Heym, Olga O. Tarkhanova, Yurii S. Moroz, Petro Borysko, V. Joachim Haupt 10.1021/acs.jmedchem.3c00128 Abstract The discovery of new scaffolds and chemotypes via high-throughput screening is tedious and resource intensive. Yet, there are millions of small molecules commercially available, rendering comprehensive in vitro tests intractable. We show how smart algorithms reduce
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11월 25일4분 분량


Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection
Xue Li, Hyun Jung Kim, Jihwan Yoo, Yeonhee Lee, Chang Hyun Nam, Jonghan Park, Soon-Tae Lee, Tae Min Kim, Seung Hong Choi, Jae-Kyung Won, Sung‑Hye Park, Young Seok Ju, Jong Bae Park, Se Hoon Kim, Jong Hee Chang, Hong-Gyun Wu, Chul-Kee Park, Jeong Ho Lee, Seok-Gu Kang & Joo Ho Lee Molecular Cancer volume 24, Article number: 64 (2025) Abstract (원문 요약) Glioblastoma (GBM) is the most aggressive and common type of primary malignant brain cancer in adults. GBM often recurs locally
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11월 25일3분 분량


Designing allosteric modulators to change GPCR G protein subtype selectivity
🔹 Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Lawrence S. Barak, Ezequiel Marron Fernandez de Velasco, Steven H. Olson & Lauren M. Slosky Nature (2025). https://doi.org/10.1038/s41586-025-09643-2 abstract G-protein-coupled receptors (GPCRs) convert extracellular signals into intracellular responses by signalling through 16 subtypes of Gα prot
한울 전
11월 18일4분 분량


Preclinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH–Wild-type Glioblastoma
Rachael A Vaubel # 1 , Wenjuan Zhang # 2 , Ju-Hee Oh 2 , Ann C Mladek 1 , Tugce I Pasa 1 , Jennifer K Gantchev 3 , Katie L Waller 1 , Gerard Baquer 3 , Sylwia A Stopka 3 , Michael S Regan 3 , Md Amin Hossain 3 , Paul A Decker 1 , Matthew L Kosel 1 , Shiv K Gupta 1 , Sonia Jain 1 , Paige P Sarkaria 1 , Zeng Hu 1 , Lauren L Ott 1 , Brett L Carlson 1 , Katie K Bakken 1 , Surabhi Talele 2 , Wenqiu Zhang 2 , Kei
한울 전
11월 18일5분 분량


Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich Science Translational Medicine, 5 January 2022 https://www.science.org/doi/10.1126/scitranslmed.abf3917 Abstract 영문 Glioblastomas (GBMs) are lethal brain tumors containing self-renewing glioblastoma stem cells (G
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11월 10일3분 분량


Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin & Maria K. Lehtinen Nature commumications, 19 January 2021 http://doi.org/10.1038/s41467-020-20666-3 Abstract: Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neu
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11월 10일2분 분량


Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar
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11월 4일2분 분량


The Blood−Brain Barrier (BBB) Score
Mayuri Gupta, Hyeok Jun Lee, Christopher J. Barden, and Donald F. Weaver 10.1021/acs.jmedchem.9b01220 Abstract The blood−brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations. Understanding the BBB interaction with drug molecules based on physicochemical property space can guide effective and efficient d
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11월 4일3분 분량


Multiparametric Assays for Accelerating Early Drug Discovery
Alexander Herholt 1 2 , Sabrina Galinski 1 2 , Philipp E. Geyer 3 4 5 , Moritz J. Rossner 1 , Michael C. Wehr 1 2 https://doi.org/10.1016/j.tips.2020.02.005 Trends in pharmacological science Volume 41, Issue 5 , May 2020, Pages 318-33 영문 초록 Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where i
한울 전
10월 31일3분 분량


Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice.
Wenzheng Zou, Yuqing Lv, Zux iang Liu, Pengyan Xia, Hong Li & Jianwei Jiao Scientific reports, 24 July 2020 http://doi.org/10.1038/s41598-020-69447-4 Abstract: Hydrocephalus is a brain disorder triggered by cerebrospinal fluid accumulation in brain cavities. Even though cerebrospinal fluid flow is known to be driven by the orchestrated beating of the bundled motile cilia of ependymal cells, little is known about the mechanism of ciliary motility. RSPH9 is increasingly becomin
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10월 22일2분 분량


Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.
Gao, Baocheng, Wang, Haoxiang, Hu, Shuang, Zhong, Kunhong, Liu, Xiaoyin1, Deng, Ziang1, Li, Yuanyou1, Tong, Aiping4, Zhou, Liangxue Neural Regeneration Research, April 30, 2025 https://doi.org/10.4103/NRR.NRR-D-24-01491 Abstract (영문) Neural stem cells (NSCs) possess self-renewal and multipotent differentiation capabilities, offering potential for treating neurological diseases. However, their survival rate after transplantation in ischemic and hypoxic environments such as p
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10월 22일3분 분량


Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Hoogstrate et al Cancer Cell , 2023 https://doi.org/10.1016/j.ccell.2023.02.019 Summary A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an interconnected continuum in a two-dimensional spac
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10월 16일3분 분량


ChemBounce: a computational framework for scaffold hopping in drug discovery
Woo Dae Jang, Changdai Gu, Yumi Noh, Kwang-Seok, Jae Yong Ryu https://doi.org/10.1093/bioinformatics/btaf501 Scaffold hopping is a critical strategy in medicinal chemistry for generating novel and patentable drug candidates. Here, we present ChemBounce, a computational framework designed to facilitate scaffold hopping by generating structurally diverse scaffolds with high synthetic accessibility. Given a user-supplied molecule in SMILES format, ChemBounce identifies the core
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10월 16일3분 분량


Topoisomerase Regulation of Cancer Gene Expression
Laura Baranello 1,* , Fedor Kouzine 2,* and David Levens 2,* https://doi.org/10.1146/annurev-biochem-091724-010717 , Annual Review of...
한울 전
10월 10일4분 분량








