

A covalent allosteric molecular glue suppresses NRF2-dependent cancer growth
Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton E, Pastuszka MK, Sigler JJ, Tran E, Hee K, McLaughlin J, Ambrus-Aikelin G, Pollock J, Abraham RT, Kinsella TM, Simon GM, Major MB, Weinstein DS, Patricelli MP. Cancer Discov . 2025 Dec 19. doi: 10.1158/215
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5일 전3분 분량


Base barrier cells provide compartmentalization of choroid plexus, brain and CSF
1.논문 제목: Base barrier cells provide compartmentalization of choroid plexus, brain and CSF 2.저자명: Daan Verhaege, Clint De Nolf, Lore Van Acker, Wouter Claeys, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Pieter Dujardin, Ward De Spiegelaere, Esther Hoste, Fleur Boone, Hart G. W. Lidov, Neil Dani, Julia Derk, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Saskia Lippens, Maria K. Lehtinen, Julie Siegenthaler, Lien Van Hoecke Roosmarijn E. Vandenbroucke 3.출처 및
김소영
3월 17일3분 분량


Strategies for blood–brain barrier rejuvenation and repair
1.논문 제목: Strategies for blood–brain barrier rejuvenation and repair 2.저자명: Matthew J. Campbell, Daniel A. Nation, Anne Eichmann, Christer Betsholtz, Berislav V. Zlokovi 3.Pub lish: Nature Reviews Drug Discovery , 2026 4.DO I: 10.1038/s41573-025-01364-5 5.Abstract: Blood–brain barrier (BBB) dysfunction is a common feature of many neurological diseases such as Alzheimer disease, stroke and other neurodegenerative disorders. Although the BBB plays a crucial role in maintainin
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3월 17일3분 분량


Evaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis
1.논문 제목: Evaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis 2.저자명: Adriana Gálvez-Ramírez, Abigail González-Valdez, Beatriz Hernández-Ochoa, Luis Miguel Canseco-Ávila, Alexander López-Roblero, Roberto Arreguin-Espinosa, Verónica Pérez de la Cruz, Elizabeth Hernández-Urzua, Noemi Cárdenas-Rodríguez, Sergio Enríquez-Flores, Ignacio De la Mora-De la Mora, Abraham Vidal-Limon, Saúl Gómez-Manzo 3.게재일: 2024 Nov 2
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3월 12일3분 분량


NRF2: KEAPing Tumors Protected
Pillai R, Hayashi M, Zavitsanou AM, Papagiannakopoulos T Cancer Discov. 2022 Mar 1;12(3):625-643. doi: 10.1158/2159-8290.CD-21-0922. The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2– related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of
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3월 3일3분 분량


Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSFhypersecretion and ventriculomegaly in hydrocephalus.
1. 논문 제목 : Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus 2. 저자명: Wu Zheng, Lanxin Hu, Yuwen Yang, Xuhang Li, JiaWu, Wangchao Chen, Yiwei Jiang, Yuhan Chen, Hongcai Wang, Shiwei Li, Kuan Feng, Cheng Zheng, Yanjiang Wang, Rodrigo A. Cunha, Zhongyue Lv & Jiang-Fan Chen 3. 출처 및 게재 (발행일): Nature communications, 07 December 2025 4. DOI : https://doi.org/10.1038/s41467-025-66776-8 5. Abstract: Hyd
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2월 24일3분 분량


Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth.
1.논문 제목: Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth. 2.저자명: Huali Su, Yaogang Zhong, Liqing He, Feng Geng, Xinmin Yin, Yongjun Kou, Cheng-Yao Chiang, Xiaokui Mo, Yunzhou Fan, Yanwei Liu, Qiang Wang, Shino Magaki, Timothy F. Cloughesy, Etienne Lefai, William H Yong, Arnab Chakravarti, Xiang Zhang, and Deliang Guo 3.Publish : 18 April 2025 4.DOI : 10.1126/sciadv.adq0334 5.Abstract: Gli
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2월 23일2분 분량


Glioma-associated microglia potentiate neuronal hyper-excitability in the glioma environment.
1.논문 제목 : Glioma-associated microglia potentiate neuronal hyper-excitability in the glioma environment. 2.저자명 : Jaeseung Yei, Na Kyeong Lee, Seungmin Ryu, Seong-Eun Ryu, Juheon Lee, Taeyoung Park, Yoonyi Jeong, Rian Kang, Ho-Keun Kwon, Seong-Gi Kim, Jong-Chan Park, Chun Gwon Park, and Minah Suh 3.Publish: 2025 July 30 4.DOI: https://doi.org/10.1093/neuonc/noaf181 5.Abstract: Hyper-excitable neurons are observed in the glioma brain, contributing to the notorious nature of g
권다현
2월 20일3분 분량


Dehydroepiandrosterone-α-2-Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF-7 Breast Cancer Cells and Inhibits Glucose-6-Phosphate Dehydrogenase Activity.
1.논문 제목: Dehydroepiandrosterone-α-2-Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF-7 Breast Cancer Cells and Inhibits Glucose-6-Phosphate Dehydrogenase Activity. 2.저자명: Hsu-Feng Liu, Shen-Chieh Chou, Sheng-Cih Huang, Tzu-Yu Huang, Po-Yun Hsiao, Feng-Pai Chou, Tung-Kung Wu 3.Publish : 26 August 2024 4.DOI : 10.1111/cbdd.14624 5.Abstract: In the pentose phosphate pathway, dehydroepiandrosterone (DHEA) uncompetitively inhibits glucose-6-phosphate dehydrogenase
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2월 20일2분 분량


Boosting the Discovery of Small Molecule Inhibitors of Glucose-6-Phosphate Dehydrogenase for the Treatment of Cancer, Infectious Diseases, and Inflammation
Ana Koperniku*, Adriana A. Garcia, and Daria Mochly-Rosen Journal of Medicinal Chemistry 2022, 65, 6, 4403-4423 초록 We present an overview of small molecule glucose6-phosphate dehydrogenase (G6PD) inhibitors that have potential for use in the treatment of cancer, infectious diseases, and inflammation. Both steroidal and nonsteroidal inhibitors have been identified with steroidal inhibitors lacking target selectivity. The main scaffolds encountered in nonsteroidal inhibitors
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2월 9일3분 분량


INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stemcell model.
1. 논문 제목: INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model. 2. 저자명: Patrick A. DeSouza, Matthew Ishahak, Xuan Qu, Colin McCornack, Devi Annamalai, Diane D.Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T. Vessoni, Ryan T. Cleary, Rowland H. Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, TingWang, Luis F. Z. Batista
김소영
2월 2일4분 분량


Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models.
논문 제목 : Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models. 저자명 : Miaomiao Sun, Maciej Bialasek, Maud Mayoux, Meng-Syuan Lin, Alicia Buck, Ilona Marszałek, Bartłomiej Taciak, Marcel Bühler, Małgorzata Górczak, Paulina Kucharzewska, Daria Kurpiel, Małgorzata Siemińska, Julia Nowakowska Brancewicz, Konrad Gabrusiewicz, Waldemar Lipiński, Sibylle Pfammatter, Steve Pascolo Gregor Hutter, Lubomi
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2월 2일3분 분량


Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity.
논문 제목 : Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity. 저자명 : Xuepeng Wei, Kathryn Kixmoeller c, Elana Baltrusaitis c, Xiaolu Yang d, Ronen Marmorstein Publish : 2022, Jul 12 DOI : https://doi.org/10.1073/pnas.2119695119 Abstract : Human glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH, and thus plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such
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1월 27일4분 분량


Unraveling the nexus: Genomic instability and metabolism in cancer
Gujar, Vaibhavi et al. Cell Reports, Volume 44, Issue 4, 115540 The DNA-damage response (DDR) is a signaling network that enables cells to detect and repair genomic damage. Over the past three decades, inhibiting DDR has proven to be an effective cancer therapeutic strategy. Although cancer drugs targeting DDR have received approval for treating various cancers, tumor cells often develop resistance to these therapies, owing to their ability to undergo energetic metabolic repr
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1월 22일3분 분량


Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma.
1. 논문 제목: H uman cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma. 2. 저자명: Brett W. Stringer, Manam Inushi De Silva1, Zarina Greenberg, Alejandra Noreña Puerta1, Robert Adams, Bridget Milky, Michael Zabolocki, Mark van den Hurk, Lisa M. Ebert, Christine Fairly Bishop, Simon J. Conn, Ganessan Kichenadasse, Michael Z. Michael, Rebecca J. Ormsby, Santosh Poonoose, Cedric Bardy 3. 출처 및 게재 (발행일): Science Advanced, 25 Octobe
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1월 13일2분 분량


Inhibiting the formation of neutrophil extracellular traps to prevent the recurrence ofpost-operative glioblastoma
1. 논문 제목: Inhibiting the formation of neutrophil extracellular traps to prevent the recurrence of post-operative glioblastoma 2. 저자명: Yaobao Han, Mengxiao Han, Tingting Wang, Hao Zhang, Hanghang Liu, Yanhui Zheng, Jun Dong & Zhen Li 3. 출처 및 게재 (발행일): Nature communications, 09 December 2025 4. DOI: https://doi.org/10.1038/s41467-025-65933-3 5. Abstract: Glioblastoma (GBM) is a highly malignant tumor with a high postoperative recurrence rate. It is crucial to develop inno
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1월 13일4분 분량


Exploiting metabolic cell death for cancer therapy
Mao, C., Jiang, D., Koong, A.C. et al. Exploiting metabolic cell death for cancer therapy. Nat Rev Cancer 26 , 27–45 (2026). https://doi.org/10.1038/s41568-025-00879-8 영문초록 Resistance to cell death is a hallmark of cancer, driving tumour progression and limiting therapeutic efficacy. Metabolic cell death pathways have been identified as unique vulnerabilities in cancer, with ferroptosis being the most extensively studied, alongside the more recently discovered pathways o
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2025년 12월 31일4분 분량


Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutantGBM to AZD1390-mediated radiosensitization.
논문 제목 : Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. 저자명 : Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Ashwin Bale, Brett L. Carlson, Kendra A. Porath, Katrina K. Bakken, Danielle M. Burgenske, Paul A. Decker, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan Harley, William F. Elmquist, Zachary D. Nagel, Shiv K. Gupta, Jann N. Sarkaria.
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2025년 12월 22일3분 분량


Virtual Screening Directly Identifies New Fragment-Sized Inhibitorsof Carboxylesterase Notum with Nanomolar Activity
논문 제목 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity 저자명 David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish,* and Fredrik Svensson Publish 2022 Jan 13 DOI https://doi.org/10.1021/acs.jmedchem.1c01735 Abstract Notum is a negative regulator of Wnt signalin
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2025년 12월 22일4분 분량


Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM.
논문 제목 Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM. 저자명 Jorge L. Jimenez-Macias, Philippa Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan Forrest, Jason Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William Hawkins, Noe Mercado, Jacqueline Real, Kelsey Huntington, Mykola Zdioruk, Michal O. Nowicki, Choi-Fong Cho, Bin Wu, Weiyi Li, Theresa Logan, Katherine E. Manz, Kurt D. Pennell, Bogda
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2025년 12월 22일3분 분량




