

INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stemcell model.
1. 논문 제목: INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model. 2. 저자명: Patrick A. DeSouza, Matthew Ishahak, Xuan Qu, Colin McCornack, Devi Annamalai, Diane D.Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T. Vessoni, Ryan T. Cleary, Rowland H. Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, TingWang, Luis F. Z. Batista
김소영
7일 전4분 분량


Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models.
논문 제목 : Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models. 저자명 : Miaomiao Sun, Maciej Bialasek, Maud Mayoux, Meng-Syuan Lin, Alicia Buck, Ilona Marszałek, Bartłomiej Taciak, Marcel Bühler, Małgorzata Górczak, Paulina Kucharzewska, Daria Kurpiel, Małgorzata Siemińska, Julia Nowakowska Brancewicz, Konrad Gabrusiewicz, Waldemar Lipiński, Sibylle Pfammatter, Steve Pascolo Gregor Hutter, Lubomi
지우 이
2월 2일3분 분량


Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity.
논문 제목 : Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity. 저자명 : Xuepeng Wei, Kathryn Kixmoeller c, Elana Baltrusaitis c, Xiaolu Yang d, Ronen Marmorstein Publish : 2022, Jul 12 DOI : https://doi.org/10.1073/pnas.2119695119 Abstract : Human glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH, and thus plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such
임지현
1월 27일4분 분량


Unraveling the nexus: Genomic instability and metabolism in cancer
Gujar, Vaibhavi et al. Cell Reports, Volume 44, Issue 4, 115540 The DNA-damage response (DDR) is a signaling network that enables cells to detect and repair genomic damage. Over the past three decades, inhibiting DDR has proven to be an effective cancer therapeutic strategy. Although cancer drugs targeting DDR have received approval for treating various cancers, tumor cells often develop resistance to these therapies, owing to their ability to undergo energetic metabolic repr
한울 전
1월 22일3분 분량


Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma.
1. 논문 제목: H uman cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma. 2. 저자명: Brett W. Stringer, Manam Inushi De Silva1, Zarina Greenberg, Alejandra Noreña Puerta1, Robert Adams, Bridget Milky, Michael Zabolocki, Mark van den Hurk, Lisa M. Ebert, Christine Fairly Bishop, Simon J. Conn, Ganessan Kichenadasse, Michael Z. Michael, Rebecca J. Ormsby, Santosh Poonoose, Cedric Bardy 3. 출처 및 게재 (발행일): Science Advanced, 25 Octobe
지우 이
1월 13일2분 분량


Inhibiting the formation of neutrophil extracellular traps to prevent the recurrence ofpost-operative glioblastoma
1. 논문 제목: Inhibiting the formation of neutrophil extracellular traps to prevent the recurrence of post-operative glioblastoma 2. 저자명: Yaobao Han, Mengxiao Han, Tingting Wang, Hao Zhang, Hanghang Liu, Yanhui Zheng, Jun Dong & Zhen Li 3. 출처 및 게재 (발행일): Nature communications, 09 December 2025 4. DOI: https://doi.org/10.1038/s41467-025-65933-3 5. Abstract: Glioblastoma (GBM) is a highly malignant tumor with a high postoperative recurrence rate. It is crucial to develop inno
김소영
1월 13일4분 분량


Exploiting metabolic cell death for cancer therapy
Mao, C., Jiang, D., Koong, A.C. et al. Exploiting metabolic cell death for cancer therapy. Nat Rev Cancer 26 , 27–45 (2026). https://doi.org/10.1038/s41568-025-00879-8 영문초록 Resistance to cell death is a hallmark of cancer, driving tumour progression and limiting therapeutic efficacy. Metabolic cell death pathways have been identified as unique vulnerabilities in cancer, with ferroptosis being the most extensively studied, alongside the more recently discovered pathways o
한울 전
2025년 12월 31일4분 분량


Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutantGBM to AZD1390-mediated radiosensitization.
논문 제목 : Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. 저자명 : Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Ashwin Bale, Brett L. Carlson, Kendra A. Porath, Katrina K. Bakken, Danielle M. Burgenske, Paul A. Decker, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan Harley, William F. Elmquist, Zachary D. Nagel, Shiv K. Gupta, Jann N. Sarkaria.
이지우
2025년 12월 22일3분 분량


Virtual Screening Directly Identifies New Fragment-Sized Inhibitorsof Carboxylesterase Notum with Nanomolar Activity
논문 제목 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity 저자명 David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish,* and Fredrik Svensson Publish 2022 Jan 13 DOI https://doi.org/10.1021/acs.jmedchem.1c01735 Abstract Notum is a negative regulator of Wnt signalin
임지현
2025년 12월 22일4분 분량


Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM.
논문 제목 Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM. 저자명 Jorge L. Jimenez-Macias, Philippa Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan Forrest, Jason Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William Hawkins, Noe Mercado, Jacqueline Real, Kelsey Huntington, Mykola Zdioruk, Michal O. Nowicki, Choi-Fong Cho, Bin Wu, Weiyi Li, Theresa Logan, Katherine E. Manz, Kurt D. Pennell, Bogda
이지우
2025년 12월 22일3분 분량


Glioblastoma remodeling of human neural circuits decreases survival.
1. 논문 제목: Glioblastoma remodeling of human neural circuits decreases survival. 2. 저자명: Saritha Krishna, Abrar Choudhury, Michael B. Keough, Kyounghee Seo, Lijun Ni, Sofia Kakaizada, Anthony Lee, Alexander Aabedi, Galina Popova, Benjamin Lipkin, Caroline Cao, Cesar Nava Gonzales, Rasika Sudharshan, Andrew Egladyous, Nyle Almeida, Yalan Zhang, Annette M. Molinaro, Humsa S. Venkatesh, Andy G. S. Daniel, Kiarash Shamardani, Jeanette Hyer, Edward F. Chang, Anne Findlay, Joanna
김소영
2025년 12월 22일2분 분량


Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus
1. 논문 제목: Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus 2. 저자명: Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao,
김소영
2025년 12월 15일2분 분량


Screening for Tumor Microtube-Targeting Drugs Identifies PKC Modulators as Multipotent Inhibitors of Glioblastoma Progression
D Azorín D, Hoffmann DC, Hebach NR, Jung E, Hausmann D, Ratliff M, Hai L, Horschitz S, Jabali A, Osswald M, Karreman MA, Kessler T, Wendler S, Mayer CD, Löb C, Lehnert P, Cebulla G, Reibold D, Khajuria RK, Bordignon P, Moor AE, Holland-Letz T, Reckless J, Ramsden N, Grainger D, Kreshuk A, Koch P, Wick W, Heuer S, Winkler F. Cancer Discovery. 2025 Oct 9. doi: 10.1158/2159-8290.CD-24-0414 영문초록 Glioblastomas are incurable primary brain tumors that depend on neural-like cellula
한울 전
2025년 12월 11일3분 분량


AI-Powered Virtual Screening of Large Compound Libraries Leads to the Discovery of Novel Inhibitors of Sirtuin-1
Anastasiia Gryniukova, Florian Kaiser, Iryna Myziuk, Diana Alieksieieva, Christoph Leberecht, Peter P. Heym, Olga O. Tarkhanova, Yurii S. Moroz, Petro Borysko, V. Joachim Haupt 10.1021/acs.jmedchem.3c00128 Abstract The discovery of new scaffolds and chemotypes via high-throughput screening is tedious and resource intensive. Yet, there are millions of small molecules commercially available, rendering comprehensive in vitro tests intractable. We show how smart algorithms reduce
임지현
2025년 11월 25일4분 분량


Distant origin of glioblastoma recurrence: neural stem cells in the subventricular zone serve as a source of tumor reconstruction after primary resection
Xue Li, Hyun Jung Kim, Jihwan Yoo, Yeonhee Lee, Chang Hyun Nam, Jonghan Park, Soon-Tae Lee, Tae Min Kim, Seung Hong Choi, Jae-Kyung Won, Sung‑Hye Park, Young Seok Ju, Jong Bae Park, Se Hoon Kim, Jong Hee Chang, Hong-Gyun Wu, Chul-Kee Park, Jeong Ho Lee, Seok-Gu Kang & Joo Ho Lee Molecular Cancer volume 24, Article number: 64 (2025) Abstract (원문 요약) Glioblastoma (GBM) is the most aggressive and common type of primary malignant brain cancer in adults. GBM often recurs locally
차혜욱
2025년 11월 25일3분 분량


Designing allosteric modulators to change GPCR G protein subtype selectivity
🔹 Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Lawrence S. Barak, Ezequiel Marron Fernandez de Velasco, Steven H. Olson & Lauren M. Slosky Nature (2025). https://doi.org/10.1038/s41586-025-09643-2 abstract G-protein-coupled receptors (GPCRs) convert extracellular signals into intracellular responses by signalling through 16 subtypes of Gα prot
한울 전
2025년 11월 18일4분 분량


Preclinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH–Wild-type Glioblastoma
Rachael A Vaubel # 1 , Wenjuan Zhang # 2 , Ju-Hee Oh 2 , Ann C Mladek 1 , Tugce I Pasa 1 , Jennifer K Gantchev 3 , Katie L Waller 1 , Gerard Baquer 3 , Sylwia A Stopka 3 , Michael S Regan 3 , Md Amin Hossain 3 , Paul A Decker 1 , Matthew L Kosel 1 , Shiv K Gupta 1 , Sonia Jain 1 , Paige P Sarkaria 1 , Zeng Hu 1 , Lauren L Ott 1 , Brett L Carlson 1 , Katie K Bakken 1 , Surabhi Talele 2 , Wenqiu Zhang 2 , Kei
한울 전
2025년 11월 18일5분 분량


Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich Science Translational Medicine, 5 January 2022 https://www.science.org/doi/10.1126/scitranslmed.abf3917 Abstract 영문 Glioblastomas (GBMs) are lethal brain tumors containing self-renewing glioblastoma stem cells (G
이지우
2025년 11월 10일3분 분량


Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin & Maria K. Lehtinen Nature commumications, 19 January 2021 http://doi.org/10.1038/s41467-020-20666-3 Abstract: Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neu
김소영
2025년 11월 10일2분 분량


Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar
차혜욱
2025년 11월 4일2분 분량








