

Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
1. 논문 제목: Combined integrin αvß3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect. 2. 저자명: Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng and Aimin Li 3. 출처 및 게재 (발행일): Journal of Nanobiotechnology, 23 December 2021 4. DOI: https://doi.org/10.1186/s12951-021-01180-0 5. Abstract: The integrin αvβ3 receptor and Lactoferrin receptor (LfR) are over-expressed in both cerebral microvascular
김소영
9월 8일3분 분량


Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy
1.논문 제목: Synchronous Disintegration of Ferroptosis Defense Axis via Engineered Exosome-Conjugated Magnetic Nanoparticles for Glioblastoma Therapy 2.저자명: Boyan Li, Xin Chen, J. Dong, S. Zhang, W. Qin, R. Zhang, Z. Peng, S. Zhang, Q. Guo, Y. Qin, W. Wang, L. Deng, S. Nie, Y. Sun, H. Xu, H. Li, G. Liu 3.Publish: Advanced Science, 2022 4.DOI: 10.1002/advs.202105451 5.Abstract: GBM은 높은 악성도와 BBB로 인해 약물이 종양에 효과적으로 전달되기 어렵다. 또한 페롭토시스를 이용한 치료에서도 암세포가 여러 방어기전을 통해 페롭토시스를 회피할 수 있다. 본 연구에
지우 이
9월 8일3분 분량


Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer
1.논문 제목: Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer 2.저자명: Congjun Xu, Zhanghong Xiao, Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, Chunshun Zhao 3.Publish: September 10, 2021 4.DOI: https://doi.org/10.1021/acs.jmedchem.1c00569 5.Abstract: Potent and selective ferroptosis regulators promote an intensive understanding of the regulation and mechanisms underlying ferroptos
임지현
9월 1일3분 분량


Posttranslational modifications remodel proteome-wide ligandability
Li, W., Wei, Q., Llanos, M. et al. Nat Chem Biol (2026). https://doi.org/10.1038/s41589-026-02216-y Posttranslational modifications (PTMs) vastly expand the diversity of the human proteome, dynamically reshaping protein activity, interactions and localization in response to environmental, pharmacologic and disease-associated cues. However, their proteome-wide impact on small-molecule recognition—and, thus, druggability—remains largely unexplored. Here we present a chemical pr
한울 전
8월 24일3분 분량


Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment
1.논문 제목: Insights into Targeted and Stimulus-Responsive Nanocarriers for Brain Cancer Treatment 2.저자명: Zahra Abousalman-Rezvani, Ahmed Refaat, Pouya Dehghankelishadi, Hossein Roghani-Mamaqani, Lars Esser, and Nicolas H. Voelcker 3. 출처 및 게재 : Advanced Healthcare Materials, 7 March 2024 4. DOI: https://doi.org/10.1002/adhm.202302902 5. Abstract: Brain cancers, especially glioblastoma multiforme, are associated with poor prognosis due to the limited efficacy of current therapies
김소영
8월 18일3분 분량


Preparation and application of pH-responsive drug delivery systems
1.논문 제목: Preparation and application of pH-responsive drug delivery systems 2.저자명: Haitao Ding, Ping Tan, Shiqin Fu, Xiaohe Tian, Hu Zhang, Xuelei Ma, Zhongwei Gu, Kui Luo. 3.출처 및 게재일: Journal of Controlled Release, 2022 4.DOI: 10.1016/j.jconrel.2022.05.056 5.Abstract: pH-responsive drug delivery systems are designed to exploit differences in pH between normal and pathological tissues to achieve controlled and site-specific drug release. Because tumors, inflammatory tissues,
지우 이
8월 18일4분 분량


Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells
1.논문 제목: Synergism of non‑thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS/AMPK/mTOR axis in lung cancer cells 2.저자명: Shengjie Peng, Guodong Chen, K. N. Yu, Yue Feng, Lele Zhao, Miaomiao Yang, Wei Cao, Waleed Abdelbagi Ahmed Almahi, Mingyu Sun, Yuan Xu, Ye Zhao, Cheng Cheng, Fengqin Zhu, Wei Han. 3.Publish: 12 February 2024 4.DOI: 10.1186/s12964-023-01382-z 5.Abstract: Though (1S, 3R)-RSL3 has been used widely
임지현
8월 10일5분 분량


Landscape of surfaceome and endocytome in human glioma is divergent and depends on cellular spatial organization
Governa et al., Proceedings of the National Academy of Sciences, 2022 DOI: 10.1073/pnas.2114456119 Therapeutic strategies directed at the tumor surfaceome (TS),including checkpoint inhibitor blocking antibodies, antibody drug conjugates (ADCs), and chimeric antigen receptor T (CAR-T) cells, provide a new armament to fight cancer. However, a remaining bottleneck is the lack of strategies to comprehensively interrogate patient tumors for potential TS targets. Here, we have deve
한울 전
8월 10일5분 분량


Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain
1. 논문 제목: Inhibitory effects of temozolomide on glioma cells is sensitized by RSL3-induced ferroptosis but negatively correlated with expression of ferritin heavy chain 1 and ferritin light chain 2. 저자명: Fei-Cheng Yang, Chuan Wang, Jiang Zhu, Qu-Jing Gai, Min Mao, Jiang He, Yan Qin, Xiao-Xue Yao, Yan-Xia Wang, Hui-Min Lu, Mian-Fu Cao, Ming-Min He, Xian-Mei Wen, Ping Leng, Xiong-Wei Cai, Xiao-Hong Yao, Xiu-Wu Bian and Yan Wang 3. 출처 및 게재 (발행일): Laboratory Investigation, 25 Feb
김소영
8월 3일3분 분량


Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer
1.논문 제목: Tumor-specific GPX4 degradation enhances ferroptosis-initiated antitumor immune response in mouse models of pancreatic cancer. 2.저자명: Jingbo Li, Jiao Liu, Zhuan Zhou, Runliu Wu, Xin Chen, Chunhua Yu, Brent Stockwell, Guido Kroemer, Rui Kang, Daolin Tang. 3.Publish: Science Translational Medicine, 1 November, 2023 4.DOI: 10.1126/scitranslmed.adg3049 5.Abstract: Current ferroptosis inducers effectively kill cancer cells by inhibiting GPX4 but also damage immune cells,
지우 이
8월 3일3분 분량


Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma
1.논문 제목: Repurposed pizotifen malate targeting NRF2 exhibits anti-tumor activity through inducing ferroptosis in esophageal squamous cell carcinoma 2.저자명: Xinyu He, Yubing Zhou, Wenjing Chen, Xiaokun Zhao, Lina Duan, Hao Zhou, Mingzhu Li, Yin Yu, Jimin Zhao, Yaping Guo, Huihui Gu, Yanan Jiang, Zigang Dong, Kangdong Liu 3.Publish: 25 February 2023 4.DOI: https://doi.org/10.1038/s41388-023-02636-3 5.Abstract: Targeted therapy attempts are needed to enhance esophageal squamous c
임지현
7월 27일4분 분량


ARE-PROTACs Enable Co-degradation of an Nrf2–MafG Heterodimer
Ji J, Ma S, Zhu Y, Zhao J, Tong Y, You Q, Jiang Z. ARE-PROTACs Enable Co-degradation of an Nrf2-MafG Heterodimer. J Med Chem. 2023 May 11;66(9):6070-6081. doi: 10.1021/acs.jmedchem.2c01909. Proteolysis-targeting chimera (PROTAC) technology has emerged as a potential strategy to degrade “undruggable” proteins in recent years. Nrf2, an aberrantly activated transcription factor in cancer, is generally considered undruggable as lacking active sites or allosteric pockets. Here, we
한울 전
7월 21일3분 분량


Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma
1.논문 제목: Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma 2.저자명: Songlei Zhou, Yukun Huang, YuChen, Yipu Liu, Laozhi Xie, YangYou, Shiqiang Tong, Jianpei Xu, Gan Jiang, Qingxiang Song, Ni Mei, Fenfen Ma, Xiaoling Gao, Hongzhuan Chen & Jun Chen 3. 출처 및 게재 (발행일): Nature communications, 26 January 2023 4. DOI: https://doi.org/10.1038/s41467-023-35957-8 5. Abstract: The limited benefits of immunotherapy against glioblastoma (GBM) is
김소영
7월 13일3분 분량


NRF2 promotes ferroptosis sensitivity in temozolomide-resistant glioblastoma cells through MRP1/ABCC1 regulation
1.논문 제목: NRF2 promotes ferroptosis sensitivity in temozolomide-resistant glioblastoma cells through MRP1/ABCC1 regulation 2.저자명: Isabela de Souza, Luiza K. S. Moreira, Camila B. Gomes, Marina T. Andrade, Bruna C. Carvalho, Mariana M. Silva, Bruno F. M. M. Pereira, Mariana T. Latancia, Daniela Menck, Marcelo Lancellotti, Luiz R. G. Gomes, C. R. R. Rocha 3.Publish: July 1, 2022 4.DOI: 10.1038/s41419-022-05044-9 5.Abstract: Glioblastoma frequently develops resistance to temozolo
지우 이
7월 13일3분 분량


Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery
1.논문 제목: Pocket Crafter: a 3D generative modeling based workflow for the rapid generation of hit molecules in drug discovery 2.저자명: Lingling Shen, Jian Fang, Lulu Liu, Fei Yang, Jeremy L. Jenkins, Peter S. Kutchukian, He Wang 3.Publish: 21 March 2024 4.DOI: https://doi.org/10.1186/s13321-024-00829-w 5.Abstract: We present a user-friendly molecular generative pipeline called Pocket Crafter, specifically designed to facilitate hit-finding activity in the drug discovery process.
임지현
7월 9일3분 분량


Microglial SRGN aggravates neuroinflammation after ischemic stroke via interacting with CD44
1.논문 제목: Microglial SRGN aggravates neuroinflammation after ischemic stroke via interacting with CD44 2.저자명: Yi Qian, Lixuan Yang, Jian Chen, Na Zhang, Yuting Gu, Xiaofei Bao, Shuxuan Xie, Hai Yu, Yanchun Chen, Chao Zhao, Yun Xu 3.출처 및 게제일: Journal of Neuroinflammation, 29 January 2024 4.DOI: http://dio.org/10.1186/s12974-024-03026-6. 5.Abstract: Ischemic stroke triggers severe neuroinflammation driven largely by activated microglia. This study investigated the role of Sergly
지우 이
6월 30일2분 분량


Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy
1.논문 제목: Co-delivering macrophage engager mRNA and PD-L1 antibody via tumor-responsive nanoparticles for glioblastoma immunotherapy 2.저자명: Haoge Zhang, JiaMiao, LinGao, Xuhong Yang, Zhengcheng Yun, LeiDong, Wanqing Cheng, Yuqi Wang, Hui Yang, Ying Zhou, Yini Zhu & Jinbing Xie 3.출처 및 게제일: Nature communications, 11 April 2026 4.DOI: https://doi.org/10.1038/s41467-026-71646-y 5.Abstract: Bispecific immune cell engagers, particularly bispecific T-cell engagers, show limited effic
김소영
6월 29일3분 분량


Activity cliff-aware reinforcement learning for de novo drug design
1.논문 제목: Activity cliff-aware reinforcement learning for de novo drug design 2.저자명: Xiuyuan Hu, Guoqing Liu, Yang Zhao, Hao Zhang 3.Publish: 21 April 2025 4.DOI: https://doi.org/10.1186/s13321-025-01006-3 5.Abstract: The integration of artificial intelligence (AI) in drug discovery offers promising opportunities to streamline and enhance the traditional drug development process. One core challenge in de novo molecular design is modeling complex structure-activity relationship
임지현
6월 22일4분 분량


The membrane receptor CD44: novel insights into metabolism
Weng X, Maxwell-Warburton S, Hasib A, Ma L, Kang L. The membrane receptor CD44: novel insights into metabolism. Trends Endocrinol Metab. 2022 May;33(5):318-332. doi: 10.1016/j.tem.2022.02.002. Epub 2022 Mar 4. PMID: 35249813. 초록 CD44, a cell-surface glycoprotein, has long been studied as a cancer molecule due to its essential role in physiological activities in normal cells and pathological activities in cancer cells, such as cell proliferation, adhesion, and migration; angio
한울 전
6월 17일3분 분량


Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mousemodels of glioblastoma.
1. 논문 제목: Dual phagocytosis-checkpoint blockade revitalizes immune surveillance in mouse models of glioblastoma. 2. 저자명: JongHoon Ha, Yifan Wang, YifanMa, Annette Wu, Shiyan Dong, Seong Dong Jeong, Jared L. Edwards, Mengyu Chang, Yen-Tzu Chang, XiaotianWang, MauriceDufilho, Michelle Najarro Torres, Shannon McCabe, Weiye Deng, Adam J. Grippin, Jeffrey S. Weinberg, ShaanM. Raza, Franco DeMonte, Ian E. McCutcheon, Sujit Prabhu, Sherise D. Ferguson, Chibawanye I. Ene, Kadir Akdem
김소영
6월 8일3분 분량




