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Pillai R, Hayashi M, Zavitsanou AM, Papagiannakopoulos T Cancer Discov. 2022 Mar 1;12(3):625-643. doi: 10.1158/2159-8290.CD-21-0922. The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2– related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of stress, and...

Ana Koperniku*, Adriana A. Garcia, and Daria Mochly-Rosen Journal of Medicinal Chemistry   2022, 65, 6, 4403-4423 초록 We present an overview of small molecule glucose6-phosphate dehydrogenase (G6PD) inhibitors that have potential for use in the treatment of cancer, infectious diseases, and inflammation. Both steroidal and nonsteroidal inhibitors have been identified with steroidal inhibitors lacking target selectivity. The main scaffolds encountered in nonsteroidal inhibitors are...

Gujar, Vaibhavi et al. Cell Reports, Volume 44, Issue 4, 115540 The DNA-damage response (DDR) is a signaling network that enables cells to detect and repair genomic damage. Over the past three decades, inhibiting DDR has proven to be an effective cancer therapeutic strategy. Although cancer drugs targeting DDR have received approval for treating various cancers, tumor cells often develop resistance to these therapies, owing to their ability to undergo energetic metabolic reprogramming....