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🔹  Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Lawrence S. Barak, Ezequiel Marron Fernandez de Velasco, Steven H. Olson & Lauren M. Slosky Nature (2025). https://doi.org/10.1038/s41586-025-09643-2 abstract G-protein-coupled receptors (GPCRs) convert extracellular signals into intracellular responses by signalling through 16 subtypes of Gα proteins and two...

Rachael A Vaubel   #   1 ,  Wenjuan Zhang   #   2 ,  Ju-Hee Oh   2 ,  Ann C Mladek   1 ,  Tugce I Pasa   1 ,  Jennifer K Gantchev   3 ,  Katie L Waller   1 ,  Gerard Baquer   3 ,  Sylwia A Stopka   3 ,  Michael S Regan   3 ,  Md Amin Hossain   3 ,  Paul A Decker   1 ,  Matthew L Kosel   1 ,  Shiv K Gupta   1 ,  Sonia Jain   1 ,  Paige P Sarkaria   1 ,  Zeng Hu   1 ,  Lauren L Ott   1 ,  Brett L Carlson   1 ,  Katie K Bakken   1 ,  Surabhi Talele   2 ,  Wenqiu Zhang   2 ,  Keith L Ligon   4 , ...

Alexander Herholt  1   2 , Sabrina Galinski  1   2 , Philipp E. Geyer  3   4   5 ,  Moritz J. Rossner  1 , Michael C. Wehr  1   2 https://doi.org/10.1016/j.tips.2020.02.005 Trends in pharmacological science Volume 41, Issue 5 , May 2020, Pages 318-33 영문 초록 Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where insufficient...