

Designing allosteric modulators to change GPCR G protein subtype selectivity
🔹 Madelyn N. Moore, Kelsey L. Person, Valeria L. Robleto, Abigail R. Alwin, Campbell L. Krusemark, Noah Foster, Caroline Ray, Asuka Inoue, Michael R. Jackson, Michael J. Sheedlo, Lawrence S. Barak, Ezequiel Marron Fernandez de Velasco, Steven H. Olson & Lauren M. Slosky Nature (2025). https://doi.org/10.1038/s41586-025-09643-2 abstract G-protein-coupled receptors (GPCRs) convert extracellular signals into intracellular responses by signalling through 16 subtypes of Gα prot
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2025년 11월 18일4분 분량


Preclinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH–Wild-type Glioblastoma
Rachael A Vaubel # 1 , Wenjuan Zhang # 2 , Ju-Hee Oh 2 , Ann C Mladek 1 , Tugce I Pasa 1 , Jennifer K Gantchev 3 , Katie L Waller 1 , Gerard Baquer 3 , Sylwia A Stopka 3 , Michael S Regan 3 , Md Amin Hossain 3 , Paul A Decker 1 , Matthew L Kosel 1 , Shiv K Gupta 1 , Sonia Jain 1 , Paige P Sarkaria 1 , Zeng Hu 1 , Lauren L Ott 1 , Brett L Carlson 1 , Katie K Bakken 1 , Surabhi Talele 2 , Wenqiu Zhang 2 , Kei
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2025년 11월 18일5분 분량


Burden of Central Nervous System Cancer in the United States, 1990-2021
GBD 2021 US CNS Cancer Collaborators 2025년 11월3일 JAMA Neurol . Published online: November 3, 2025. Doi: 10.1001/jamaneurol.2025.4286 Abstract Importance Primary brain and central nervous system cancer (collectively referred to as CNS cancer) comprises 2% of all human cancers and poses significant health and economic challenges in the United States. Objectives To analyze CNS cancer burden in the US, stratified by time, location (state and division), sex, age group, and S
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2025년 11월 11일3분 분량


Glioblastoma stem cells reprogram chromatin in vivo to generate selective therapeutic dependencies on DPY30 and phosphodiesterases.
Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich Science Translational Medicine, 5 January 2022 https://www.science.org/doi/10.1126/scitranslmed.abf3917 Abstract 영문 Glioblastomas (GBMs) are lethal brain tumors containing self-renewing glioblastoma stem cells (G
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2025년 11월 10일3분 분량


Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin & Maria K. Lehtinen Nature commumications, 19 January 2021 http://doi.org/10.1038/s41467-020-20666-3 Abstract: Cerebrospinal fluid (CSF) provides vital support for the brain. Abnormal CSF accumulation, such as hydrocephalus, can negatively affect perinatal neu
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2025년 11월 10일2분 분량


Spatially resolved multi-omics deciphers bidirectional tumor-host interdependence in glioblastoma
Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar
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2025년 11월 4일2분 분량


The Blood−Brain Barrier (BBB) Score
Mayuri Gupta, Hyeok Jun Lee, Christopher J. Barden, and Donald F. Weaver 10.1021/acs.jmedchem.9b01220 Abstract The blood−brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations. Understanding the BBB interaction with drug molecules based on physicochemical property space can guide effective and efficient d
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2025년 11월 4일3분 분량


Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas A Randomized Clinical Trial
Chengcheng Guo, MD, PhD 1 ; Qunying Yang, MD, PhD 1 ; Pengfei Xu, MD, PhD 1 Meiling Deng, MD, PhD 2 ; Taipeng Jiang, MD, PhD 3 ; Linbo Cai, MD, PhD 4 ; Jibin Li, MD, PhD 5 ; Ke Sai, MD, PhD 1 ; Shaoyan Xi, MD, PhD 6 ; Hui Ouyang, MD, PhD 7 ; Mingfa Liu, MD, PhD 8 ; Xianming Li, MD, PhD 9,10 ; Zihuang Li, MD, PhD 9,10 ; Xiangrong Ni, MD, PhD 1 ; Xi Cao, BSN 1 ; Cong Li, MD, PhD 11,12 ; Shaoxiong Wu, MD, PhD 2 ; Xiaojing Du, MD, PhD 2 ; Jun Su, MD, PhD 13 ; Xi
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2025년 11월 3일4분 분량
SOFA-2: 장기부전 평가의 새로운 시대
JAMA 2025. Ranzani et al.-30년 만의 전면 개정
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2025년 10월 31일1분 분량


Development and Validation of the Sequential Organ Failure Assessment (SOFA)-2 Score
Otavio T. Ranzani, MD, MSc, PhD 1,2,3 ; Mervyn Singer, MD 4 ; Jorge I. F. Salluh, MD, PhD 5 et al 2025년 10월 29일 JAMA Published Online: October 29, 2025 DOI: 10.1001/jama.2025.20516 Abstract Importance Acute dysfunction of vital organs is the hallmark of critical illness. The Sequential Organ Failure Assessment (SOFA) score, the most widely adopted approach to describe organ dysfunction, has not been updated in 30 years and therefore may not appropriately capture current c
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2025년 10월 31일3분 분량


Multiparametric Assays for Accelerating Early Drug Discovery
Alexander Herholt 1 2 , Sabrina Galinski 1 2 , Philipp E. Geyer 3 4 5 , Moritz J. Rossner 1 , Michael C. Wehr 1 2 https://doi.org/10.1016/j.tips.2020.02.005 Trends in pharmacological science Volume 41, Issue 5 , May 2020, Pages 318-33 영문 초록 Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where i
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2025년 10월 31일3분 분량


Loss of Rsph9 causes neonatal hydrocephalus with abnormal development of motile cilia in mice.
Wenzheng Zou, Yuqing Lv, Zux iang Liu, Pengyan Xia, Hong Li & Jianwei Jiao Scientific reports, 24 July 2020 http://doi.org/10.1038/s41598-020-69447-4 Abstract: Hydrocephalus is a brain disorder triggered by cerebrospinal fluid accumulation in brain cavities. Even though cerebrospinal fluid flow is known to be driven by the orchestrated beating of the bundled motile cilia of ependymal cells, little is known about the mechanism of ciliary motility. RSPH9 is increasingly becomin
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2025년 10월 22일2분 분량


Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus.
Gao, Baocheng, Wang, Haoxiang, Hu, Shuang, Zhong, Kunhong, Liu, Xiaoyin1, Deng, Ziang1, Li, Yuanyou1, Tong, Aiping4, Zhou, Liangxue Neural Regeneration Research, April 30, 2025 https://doi.org/10.4103/NRR.NRR-D-24-01491 Abstract (영문) Neural stem cells (NSCs) possess self-renewal and multipotent differentiation capabilities, offering potential for treating neurological diseases. However, their survival rate after transplantation in ischemic and hypoxic environments such as p
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2025년 10월 22일3분 분량


Transcriptome analysis reveals tumor microenvironment changes in glioblastoma
Hoogstrate et al Cancer Cell , 2023 https://doi.org/10.1016/j.ccell.2023.02.019 Summary A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an interconnected continuum in a two-dimensional spac
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2025년 10월 16일3분 분량


ChemBounce: a computational framework for scaffold hopping in drug discovery
Woo Dae Jang, Changdai Gu, Yumi Noh, Kwang-Seok, Jae Yong Ryu https://doi.org/10.1093/bioinformatics/btaf501 Scaffold hopping is a critical strategy in medicinal chemistry for generating novel and patentable drug candidates. Here, we present ChemBounce, a computational framework designed to facilitate scaffold hopping by generating structurally diverse scaffolds with high synthetic accessibility. Given a user-supplied molecule in SMILES format, ChemBounce identifies the core
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2025년 10월 16일3분 분량


Primary brain tumours in adults
Prof Martin J van den Bent, MD a m.vandenbent@erasmusmc.nl ∙ Marjolein Geurts, MD a ∙ Pim J French, PhD a ∙ ...
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2025년 10월 13일3분 분량


Topoisomerase Regulation of Cancer Gene Expression
Laura Baranello 1,* , Fedor Kouzine 2,* and David Levens 2,* https://doi.org/10.1146/annurev-biochem-091724-010717 , Annual Review of...
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2025년 10월 10일4분 분량


Revised Diagnostic Criteria for Vascular Cognitive Impairment and Dementia—The VasCog-2-WSO Criteria
The VasCog-2-WSO Criteria Consortium 2025년09월16일 JAMA Neurol . Published online: September 16, 2025. Doi: 10.1001/jamaneurol.2025.3242...
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2025년 9월 30일2분 분량


Activation of the RARα attenuated CSF hypersecretion to inhibit hydrocephalus development via regulating the MAFB/MSR1 pathway
Hanhai Zeng, Kaibo Yu, Junyou Wang, Jingya Ye, Huaijun Chen, Chaoran Xu, Ting Chen, Feng Yan, Gao Chen and Chi Gu 출처 및 게재 (발행일):...
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2025년 9월 29일2분 분량


Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription
Aziz Taghbalout 1,6 ∙ Chia-Hao Tung 1,6 ∙ Patricia A. Clow 2 ∙ Harianto Tjong 2 ∙ Ping Wang 2,5 ∙ Chee Hong Wong 1 ∙ Diane...
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2025년 9월 29일2분 분량




