Vidhya M. Ravi et al. Cancer Cell , 2022 https://doi.org/10.1016/j.ccell.2022.05.009 Summary Glioblastomas are malignant tumors of the central nervous system hallmarked by subclonal diversity and dynamic adaptation amid developmental hierarchies. The source of dynamic reorganization within the spatial context of these tumors remains elusive. Here, we characterized glioblastomas by spatially resolved transcriptomics, metabolomics, and proteomics. By deciphering regionally shar

Mayuri Gupta, Hyeok Jun Lee, Christopher J. Barden, and Donald F. Weaver 10.1021/acs.jmedchem.9b01220 Abstract The blood−brain barrier (BBB) protects the brain from the toxic side effects of drugs and exogenous molecules. However, it is crucial that medications developed for neurological disorders cross into the brain in therapeutic concentrations. Understanding the BBB interaction with drug molecules based on physicochemical property space can guide effective and efficient d

Alexander Herholt  1   2 , Sabrina Galinski  1   2 , Philipp E. Geyer  3   4   5 ,  Moritz J. Rossner  1 , Michael C. Wehr  1   2 https://doi.org/10.1016/j.tips.2020.02.005 Trends in pharmacological science Volume 41, Issue 5 , May 2020, Pages 318-33 영문 초록 Drug discovery campaigns are hampered by substantial attrition rates largely due to a lack of efficacy and safety reasons associated with candidate drugs. This is true in particular for genetically complex diseases, where i

Wenzheng Zou, Yuqing Lv, Zux iang Liu, Pengyan Xia, Hong Li & Jianwei Jiao Scientific reports, 24 July 2020 http://doi.org/10.1038/s41598-020-69447-4 Abstract: Hydrocephalus is a brain disorder triggered by cerebrospinal fluid accumulation in brain cavities. Even though cerebrospinal fluid flow is known to be driven by the orchestrated beating of the bundled motile cilia of ependymal cells, little is known about the mechanism of ciliary motility. RSPH9 is increasingly becomin

Gao, Baocheng, Wang, Haoxiang, Hu, Shuang, Zhong, Kunhong, Liu, Xiaoyin1, Deng, Ziang1, Li, Yuanyou1, Tong, Aiping4, Zhou, Liangxue Neural Regeneration Research, April 30, 2025 https://doi.org/10.4103/NRR.NRR-D-24-01491   Abstract (영문) Neural stem cells (NSCs) possess self-renewal and multipotent differentiation capabilities, offering potential for treating neurological diseases. However, their survival rate after transplantation in ischemic and hypoxic environments such as p

Hoogstrate et al Cancer Cell , 2023 https://doi.org/10.1016/j.ccell.2023.02.019 Summary A better understanding of transcriptional evolution of IDH-wild-type glioblastoma may be crucial for treatment optimization. Here, we perform RNA sequencing (RNA-seq) (n = 322 test, n = 245 validation) on paired primary-recurrent glioblastoma resections of patients treated with the current standard of care. Transcriptional subtypes form an interconnected continuum in a two-dimensional spac

Woo Dae Jang, Changdai Gu, Yumi Noh, Kwang-Seok, Jae Yong Ryu https://doi.org/10.1093/bioinformatics/btaf501 Scaffold hopping is a critical strategy in medicinal chemistry for generating novel and patentable drug candidates. Here, we present ChemBounce, a computational framework designed to facilitate scaffold hopping by generating structurally diverse scaffolds with high synthetic accessibility. Given a user-supplied molecule in SMILES format, ChemBounce identifies the core

Laura Baranello 1,* ,  Fedor Kouzine 2,*  and  David Levens 2,* https://doi.org/10.1146/annurev-biochem-091724-010717 , Annual Review of...

Hanhai Zeng, Kaibo Yu, Junyou Wang, Jingya Ye, Huaijun Chen, Chaoran Xu, Ting Chen, Feng Yan, Gao Chen and Chi Gu 출처 및 게재 (발행일):...

Aziz Taghbalout 1,6  ∙  Chia-Hao Tung 1,6  ∙  Patricia A. Clow 2  ∙  Harianto Tjong 2  ∙  Ping Wang 2,5  ∙  Chee Hong Wong 1  ∙  Diane...

Qiguang Wang, Fei Liu, Yue Li, Huan Zhang, Xin Qi, Ke Wu, Yi Zhang, Shenglan You, Wenke Liu, Xuhui Hui, Hanmei Li, Lei Zhu, Huile Gao,...

Alexander S. Hauser, Sreenivas Chavali, Ikuo Masuho, Leonie J. Jahn, Kirill A. Martemyanov, David E. Gloriam, M. Madan Babu 11 January...

Pan F. Chan, Velupillai Srikannathasan, Jianzhong Huang, Haifeng Cui, Andrew P. Fosberry, Minghua Gu, Michael M. Hann, Martin Hibbs, Paul...

Aurélie Soubéran, Carine Jiguet-Jiglaire, SolineToutain, Philippe Morando, Nathalie Baeza-Kallee , Romain Appay, Céline Boucard, Thomas...

Yiye Li, Can Di, Shijian Song, Yubo Zhang, Yiwen Lu, Jianyou Liao, Bingxi Lei, Jian Zhong, Kaihua Guo, Nu Zhang, and Shicheng Su Cell...