Cell, Vol. 189, pp. 1341–1355, March 5, 2026 Gao X, Liu X, Wang N et al. https://www.cell.com/cell/fulltext/S0092-8674%2825%2901421-7#fig1 초록 The rapid accessibility of calvarial immune cells to the brain, in principle, may offer transformative opportunities for overcoming drug delivery barriers in central nervous system (CNS) disorders. Here, we hijacked calvarial immune cells using drug-loaded nanoparticles (NPs) and leveraged their unique migration mechanism through skull-

1.논문제목: Spatial and single-cell characterization of human glioblastoma tumor microenvironment reveals malignant cellular communities. 2.저자명: Jun Lin, Chunpeng Chen, Shouzhen Li, Liu Chen, Minghao Fang, Shuqi Fu, Kaixing Chen, Hao Xu, Fenghuan Zhang, Rirui Wang, Chen Jiang, Meifang Tang, Zitian Liu, Shuyan Wang, Ke Liu, Chaoshi Niu, Bin Li, Xu Liu, Chuandong Cheng, Ai-Hui Tang & Kun Qu 3.발행일: Nature neuroscience, 16 April 2026 4.DOI: https://doi.org/10.1038/s41593-026-02265-5

1.논문 제목: Liposomal Nanomaterials: A Rising Star in Glioma Treatment 2.저자명: Yu Gan, Yingying Yu, Huizhe Xu, Haozhe Piao. 3.Publish: 2024 July 4.DOI: 10.2147/IJN.S470478 5.Abstract: Glioma remains one of the most aggressive primary tumors of the central nervous system, with limited therapeutic efficacy due to the presence of the blood–brain barrier (BBB). Conventional treatments such as surgery, radiotherapy, and chemotherapy fail to significantly improve patient survival. Rece

1.논문제목 : Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma 2.저자명: Susan Costantini, Isabella Romeo, Giulia Fanelli, Maria Serena Roca, Gianmarco Gualtieri, Palmina Bagnara, Andrea Polo, Elena Di Gennaro, Francesco Ortuso, Stefano Alcaro, Alfredo Budillon, Gennaro Ciliberto, Marco G. Paggi, Claudia Abbruzzese 3.Pub lish: 2025 Dec 8 4.DO I : 10.1186/s12967-025-07444-9 5.Abstract 5-1 Background: Glioblastoma (GBM

Emma Martell 1,2,9, Helgi Kuzmychova 1,3,9, Ujala Chawla1 , Akaljot Grewal1,3, Charul Jain1,3, Chitra Venugopal4,5, Christopher M. Anderson2,6, Sheila K. Singh 4,5,7 and Tanveer Sharif 1,3,8 Cell Death and Disease (2026) 17:348 ; https://doi.org/10.1038/s41419-026-08646-9 초록 Glioblastoma (GBM), the most common malignant brain tumor in adults, remains a highly lethal and incurable cancer, with a 5-year survival rate below 10%. Standard-of-care involves surgical resection follo

1.논문 제목: Surface-engineered dual drug-loaded tumor-targeted liposomal nanoparticles to overcome the therapeutic resistance in glioblastoma multiforme 2.저자명 : Ramcharan Singh Angom, Hari Krishnareddy Rachamala, Naga Malleswara Rao Nakka, Vijay Sagar Madamsetty, Paola Suarez-Meade, Beatriz I. Fernandez-Gil, Tanmay Kulkarni, Raegan M. Weil, Shamit Dutta, Enfeng Wang, Santanu Bhattacharya, Krishnendu Pal, Alfredo Quinones-Hinojosa & Debabrata Mukhopadhyay 3.Pub lish: Communi

1.논문 제목 : The regulations of telomerase reverse transcriptase (TERT) in cancer 2.저자명: Mingdi Liu , Yuning Zhang , Yongping Jian , Liting Gu , Dan Zhang , Honglan Zhou , Yishu Wang & Zhi-Xiang Xu 3.Pub lish: C ell death & disease , January, 2024 4.DO I: 10.1038/s41419-024-06454-7. 5.Abstract: Telomerase reverse transcriptase (TERT) is a key regulator of cancer progression by maintaining telomere length and enabling cells to bypass replicative senescence. In most canc

1.논문 제목: CB‑Dock2: improved protein–ligand blind docking by integrating cavity detection, docking and homologous template fitting 2.저자명: Yang Liu, Xiaocong Yang, Jianhong Gan, Shuang Chen, Zhi‑Xiong Xiao, Yang Cao 3.Pub lish: 2022 Jul 5 4.DO I: 10.1093/nar/gkac394 5.Abstract: Protein-ligand blind docking is a powerful method for exploring the binding sites of receptors and the corresponding binding poses of ligands. It has seen wide applications in pharmaceutical and biolo

Roy N, Wyseure T, Lo IC, Lu J, Eissler CL, Bernard SM, Bok I, Snead AN, Parker A, Lo UG, Green JC, Inloes J, Jacinto SR, Kuenzi B, Pariollaud M, Negri K, Le K, Horning BD, Ibrahim N, Grabow S, Panda H, Bhatt DP, Wilkerson EM, Saeidi S, Zolkind P, Rush Z, Williams HN, Walton E, Pastuszka MK, Sigler JJ, Tran E, Hee K, McLaughlin J, Ambrus-Aikelin G, Pollock J, Abraham RT, Kinsella TM, Simon GM, Major MB, Weinstein DS, Patricelli MP. Cancer Discov . 2025 Dec 19. doi: 10.1158/215

1.논문 제목: Base barrier cells provide compartmentalization of choroid plexus, brain and CSF 2.저자명: Daan Verhaege, Clint De Nolf, Lore Van Acker, Wouter Claeys, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Pieter Dujardin, Ward De Spiegelaere, Esther Hoste, Fleur Boone, Hart G. W. Lidov, Neil Dani, Julia Derk, Anna Kremer, Evelien Van Hamme, Peter Borghgraef, Saskia Lippens, Maria K. Lehtinen, Julie Siegenthaler, Lien Van Hoecke Roosmarijn E. Vandenbroucke 3.출처 및

1.논문 제목: Strategies for blood–brain barrier rejuvenation and repair 2.저자명: Matthew J. Campbell, Daniel A. Nation, Anne Eichmann, Christer Betsholtz, Berislav V. Zlokovi 3.Pub lish: Nature Reviews Drug Discovery , 2026 4.DO I: 10.1038/s41573-025-01364-5 5.Abstract: Blood–brain barrier (BBB) dysfunction is a common feature of many neurological diseases such as Alzheimer disease, stroke and other neurodegenerative disorders. Although the BBB plays a crucial role in maintainin

1.논문 제목: Evaluation of Three Mutations in Codon 385 of Glucose-6-Phosphate Dehydrogenase via Biochemical and In Silico Analysis 2.저자명: Adriana Gálvez-Ramírez, Abigail González-Valdez, Beatriz Hernández-Ochoa, Luis Miguel Canseco-Ávila, Alexander López-Roblero, Roberto Arreguin-Espinosa, Verónica Pérez de la Cruz, Elizabeth Hernández-Urzua, Noemi Cárdenas-Rodríguez, Sergio Enríquez-Flores, Ignacio De la Mora-De la Mora, Abraham Vidal-Limon, Saúl Gómez-Manzo 3.게재일: 2024 Nov 2

Pillai R, Hayashi M, Zavitsanou AM, Papagiannakopoulos T Cancer Discov. 2022 Mar 1;12(3):625-643. doi: 10.1158/2159-8290.CD-21-0922. The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2– related factor 2 (NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen species. However, activation of NRF2 provides a powerful selective advantage for tumors by rewiring metabolism to enhance proliferation, suppress various forms of

1. 논문 제목 : Aberrant adenosine A2A receptor signaling in the choroid plexus drives CSF hypersecretion and ventriculomegaly in hydrocephalus 2. 저자명: Wu Zheng, Lanxin Hu, Yuwen Yang, Xuhang Li, JiaWu, Wangchao Chen, Yiwei Jiang, Yuhan Chen, Hongcai Wang, Shiwei Li, Kuan Feng, Cheng Zheng, Yanjiang Wang, Rodrigo A. Cunha, Zhongyue Lv & Jiang-Fan Chen 3. 출처 및 게재 (발행일): Nature communications, 07 December 2025 4. DOI : https://doi.org/10.1038/s41467-025-66776-8 5. Abstract: Hyd

1.논문 제목: Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth. 2.저자명: Huali Su, Yaogang Zhong, Liqing He, Feng Geng, Xinmin Yin, Yongjun Kou, Cheng-Yao Chiang, Xiaokui Mo, Yunzhou Fan, Yanwei Liu, Qiang Wang, Shino Magaki, Timothy F. Cloughesy, Etienne Lefai, William H Yong, Arnab Chakravarti, Xiang Zhang, and Deliang Guo 3.Publish : 18 April 2025 4.DOI : 10.1126/sciadv.adq0334 5.Abstract: Gli

1.논문 제목 : Glioma-associated microglia potentiate neuronal hyper-excitability in the glioma environment. 2.저자명 : Jaeseung Yei, Na Kyeong Lee, Seungmin Ryu, Seong-Eun Ryu, Juheon Lee, Taeyoung Park, Yoonyi Jeong, Rian Kang, Ho-Keun Kwon, Seong-Gi Kim, Jong-Chan Park, Chun Gwon Park, and Minah Suh 3.Publish: 2025 July 30 4.DOI: https://doi.org/10.1093/neuonc/noaf181 5.Abstract: Hyper-excitable neurons are observed in the glioma brain, contributing to the notorious nature of g

1.논문 제목: Dehydroepiandrosterone-α-2-Deoxyglucoside Exhibits Enhanced Anticancer Effects in MCF-7 Breast Cancer Cells and Inhibits Glucose-6-Phosphate Dehydrogenase Activity. 2.저자명: Hsu-Feng Liu, Shen-Chieh Chou, Sheng-Cih Huang, Tzu-Yu Huang, Po-Yun Hsiao, Feng-Pai Chou, Tung-Kung Wu 3.Publish : 26 August 2024 4.DOI : 10.1111/cbdd.14624 5.Abstract: In the pentose phosphate pathway, dehydroepiandrosterone (DHEA) uncompetitively inhibits glucose-6-phosphate dehydrogenase

Ana Koperniku*, Adriana A. Garcia, and Daria Mochly-Rosen Journal of Medicinal Chemistry 2022, 65, 6, 4403-4423 초록 We present an overview of small molecule glucose6-phosphate dehydrogenase (G6PD) inhibitors that have potential for use in the treatment of cancer, infectious diseases, and inflammation. Both steroidal and nonsteroidal inhibitors have been identified with steroidal inhibitors lacking target selectivity. The main scaffolds encountered in nonsteroidal inhibitors

1. 논문 제목: INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model. 2. 저자명: Patrick A. DeSouza, Matthew Ishahak, Xuan Qu, Colin McCornack, Devi Annamalai, Diane D.Mao, Rajanikanth Vangipurapu, Yiwei Fu, Alexandre T. Vessoni, Ryan T. Cleary, Rowland H. Han, Punn Augsornworawat, Timothy Woodiwiss, Darby Agovino, Braxton Sizemore, Jessica Kline, Maryam Borhani-Haghighi, Hao Chen, Sangami Pugazenthi, Hiroko Yano, TingWang, Luis F. Z. Batista

논문 제목 : Adoptive cell therapy with macrophage-drug conjugates facilitates cytotoxic drug transfer and immune activation in glioblastoma models. 저자명 : Miaomiao Sun, Maciej Bialasek, Maud Mayoux, Meng-Syuan Lin, Alicia Buck, Ilona Marszałek, Bartłomiej Taciak, Marcel Bühler, Małgorzata Górczak, Paulina Kucharzewska, Daria Kurpiel, Małgorzata Siemińska, Julia Nowakowska Brancewicz, Konrad Gabrusiewicz, Waldemar Lipiński, Sibylle Pfammatter, Steve Pascolo Gregor Hutter, Lubomi

논문 제목 : Allosteric role of a structural NADP+ molecule in glucose-6-phosphate dehydrogenase activity. 저자명 : Xuepeng Wei, Kathryn Kixmoeller c, Elana Baltrusaitis c, Xiaolu Yang d, Ronen Marmorstein Publish : 2022, Jul 12 DOI : https://doi.org/10.1073/pnas.2119695119 Abstract : Human glucose-6-phosphate dehydrogenase (G6PD) is the main cellular source of NADPH, and thus plays a key role in maintaining reduced glutathione to protect cells from oxidative stress disorders such

Gujar, Vaibhavi et al. Cell Reports, Volume 44, Issue 4, 115540 The DNA-damage response (DDR) is a signaling network that enables cells to detect and repair genomic damage. Over the past three decades, inhibiting DDR has proven to be an effective cancer therapeutic strategy. Although cancer drugs targeting DDR have received approval for treating various cancers, tumor cells often develop resistance to these therapies, owing to their ability to undergo energetic metabolic repr

1. 논문 제목: H uman cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma. 2. 저자명: Brett W. Stringer, Manam Inushi De Silva1, Zarina Greenberg, Alejandra Noreña Puerta1, Robert Adams, Bridget Milky, Michael Zabolocki, Mark van den Hurk, Lisa M. Ebert, Christine Fairly Bishop, Simon J. Conn, Ganessan Kichenadasse, Michael Z. Michael, Rebecca J. Ormsby, Santosh Poonoose, Cedric Bardy 3. 출처 및 게재 (발행일): Science Advanced, 25 Octobe

1. 논문 제목: Inhibiting the formation of neutrophil extracellular traps to prevent the recurrence of post-operative glioblastoma 2. 저자명: Yaobao Han, Mengxiao Han, Tingting Wang, Hao Zhang, Hanghang Liu, Yanhui Zheng, Jun Dong & Zhen Li 3. 출처 및 게재 (발행일): Nature communications, 09 December 2025 4. DOI: https://doi.org/10.1038/s41467-025-65933-3 5. Abstract: Glioblastoma (GBM) is a highly malignant tumor with a high postoperative recurrence rate. It is crucial to develop inno

Mao, C., Jiang, D., Koong, A.C. et al. Exploiting metabolic cell death for cancer therapy. Nat Rev Cancer 26 , 27–45 (2026). https://doi.org/10.1038/s41568-025-00879-8 영문초록 Resistance to cell death is a hallmark of cancer, driving tumour progression and limiting therapeutic efficacy. Metabolic cell death pathways have been identified as unique vulnerabilities in cancer, with ferroptosis being the most extensively studied, alongside the more recently discovered pathways o

논문 제목 : Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. 저자명 : Jiajia Chen, Daniel J. Laverty, Surabhi Talele, Ashwin Bale, Brett L. Carlson, Kendra A. Porath, Katrina K. Bakken, Danielle M. Burgenske, Paul A. Decker, Rachael A. Vaubel, Jeanette E. Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan Harley, William F. Elmquist, Zachary D. Nagel, Shiv K. Gupta, Jann N. Sarkaria.

논문 제목 Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity 저자명 David Steadman, Benjamin N. Atkinson, Yuguang Zhao, Nicky J. Willis, Sarah Frew, Amy Monaghan, Chandni Patel, Emma Armstrong, Kathryn Costelloe, Lorenza Magno, Magda Bictash, E. Yvonne Jones, Paul V. Fish,* and Fredrik Svensson Publish 2022 Jan 13 DOI https://doi.org/10.1021/acs.jmedchem.1c01735 Abstract Notum is a negative regulator of Wnt signalin

논문 제목 Modulation of blood-tumor barrier transcriptional programs improves intratumoral drug deliveryand potentiates chemotherapy in GBM. 저자명 Jorge L. Jimenez-Macias, Philippa Vaughn-Beaucaire, Ayush Bharati, Zheyun Xu, Megan Forrest, Jason Hong, Michael Sun, Andrea Schmidt, Jasmine Clark, William Hawkins, Noe Mercado, Jacqueline Real, Kelsey Huntington, Mykola Zdioruk, Michal O. Nowicki, Choi-Fong Cho, Bin Wu, Weiyi Li, Theresa Logan, Katherine E. Manz, Kurt D. Pennell, Bogda

1. 논문 제목: Glioblastoma remodeling of human neural circuits decreases survival. 2. 저자명: Saritha Krishna, Abrar Choudhury, Michael B. Keough, Kyounghee Seo, Lijun Ni, Sofia Kakaizada, Anthony Lee, Alexander Aabedi, Galina Popova, Benjamin Lipkin, Caroline Cao, Cesar Nava Gonzales, Rasika Sudharshan, Andrew Egladyous, Nyle Almeida, Yalan Zhang, Annette M. Molinaro, Humsa S. Venkatesh, Andy G. S. Daniel, Kiarash Shamardani, Jeanette Hyer, Edward F. Chang, Anne Findlay, Joanna

1. 논문 제목: Impaired neurogenesis alters brain biomechanics in a neuropregenitor-based genetic subtype of congenital hydrocephalus 2. 저자명: Phan Q. Duy, Stefan C. Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J. Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, Emre Kiziltug, Adam J. Kundishora, Sunil Koundal, Maysam Z. Pedram, Lucia A. Torres-Fernández, Kristian Händler, Elena De Domenico, Matthias Becker, Thomas Ulas, Stefan A. Juranek, Elisa Cuevas, Le Thi Hao,