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Neurologic recovery & Rejuvenation
Basic Research News
In vivo reprogramming of NG2 glia enables adult neurogenesis and functional recovery following spinal cord injury
Tai W, Wu W, Wang LL, Ni H, Chen C, Yang J, Zang T, Zou Y, Xu XM, Zhang CL. Cell Stem Cell. 2021 May 6;28(5):923-937.e4. doi:...
Neural stem and progenitor cells support and protect adult hippocampal function via vascular endothelial growth factor secretion
Lisa N. Miller, Ashley E. Walters, Jiyeon K. Denninger, Meretta A. Hanson, Alec H. Marshall, Aidan C. Johantges, Manal Hosawi, Gwendolyn...
α-synuclein expression in glioblastoma restores tumor suppressor function and rescues temozolomide drug resistance
Eric Duplan, Aurore Bernardin, Thomas Goiran, Nathalie Leroudier, Mathew Casimiro, Richard Pestell, Shinya Tanaka, Celine Malleval,...
High-throughput discovery of inhibitory protein fragments with AlphaFold
A. Savinov, S. Swanson, A.E. Keating, & G. Li, Natl. Acad. Sci. U.S.A. 122 (6) e2322412122, https://doi.org/10.1073/pnas.2322412122 ...
GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke
Zhang Y, Wu Z, Huang Z, Liu Y, Chen X, Zhao X, He H, Deng Y. Brain Res. 2022 Mar 1;1778:147768. doi: 10.1016/j.brainres.2021.147768....
Fate mapping of Spp1 expression reveals age-dependent plasticity of disease-associated microglia-like cells after brain injury
Lan Y, Zhang X, Liu S, Guo C, Jin Y, Li H, Wang L, Zhao J, Hao Y, Li Z, Liu Z, Ginhoux F, Xie Q, Xu H, Jia JM, He D. Immunity. 2024 Feb...
Computational drug repurposing:approaches, evaluation of in silicoresources and case studies
Nat Rev Drug Discovery. 2025 Mar 18. doi: 10.1038/s41573-025-01164-x. [작성자: 전한울] Abstract Repurposing of existing drugs for new...
Targeted protein degradation: from mechanisms to clinic
Nat Rev Mol Cell Biol 25 , 740–757 (2024) https://doi.org/10.1038/s41580-024-00729-9 Targeted protein degradation refers to the use of...
Targeted protein degradation: advances in drug discovery and clinical practice
Sig Transduct Target Ther 9 , 308 (2024) https://doi.org/10.1038/s41392-024-02004-x Targeted protein degradation (TPD) represents a...
Protein–protein interactions regulating α-synuclein pathology
Trends in Neurosciences, Volume 47, Issue 3, 209 - 226 https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(24)00014-6 Abstract...
Molecular glues for protein-protein interactions: Progressing toward a new dream
Cell Chemical Biology, Volume 31, Issue 6, 1064 - 1088 https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(24)00130-2 [작성자: ...
Targeting Neuronal GPR65 with Delayed BTB09089 Treatment Improves Neurorehabilitation Following Ischemic Stroke.
https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.046954 [작성자: 이지우] Abstract : This study explored the impact of delayed treatment...
Clinical implications of brain asymmetries
Nat Rev Neurol 20 , 383–394 (2024) https://doi.org/10.1038/s41582-024-00974-8 [작성자: 전한울] No two human brains are alike, and with the...
Neuronal maturation and axon regeneration: unfixing circuitry to enable repair
Nat. Rev. Neurosci. 25 , 649–667 (2024) https://doi.org/10.1038/s41583-024-00849-3 [작성자: 전한울] Abstract Mammalian neurons lose the...
From animal models to human individuality: Integrative approaches to the study of brain plasticity
Neuron, Volume 112, Issue 21 , 6 November 2024, Pages 3522-3541 https://doi.org/10.1016/j.neuron.2024.10.006 [작성자: 전한울] Introduction...
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