Spatial distribution of immune cells and their proximity to STING+ cells are associated with survival in glioblastoma[교신저자]

Clinical and Translational Medicine

Hanwool Jeon, Hayeong Kang, Jihyun Im, Suin Jo, Hyunchul Jung, Moinay Kim, Jae Hyun Kim, Eunyeup Lee, Soyoung Kim, Jeong Hoon Kim, Chang-Ki Hong, Young-Hoon Kim, Sang Woo Song, Jinha Park, Sang-Yeob Kim, Seungjoo Lee

Dear Editor,Glioblastoma (GBM), the most aggressive malignanttumour, is increasingly treated with immunotherapy.1–3The stimulator of interferon genes (STING) pathway4is key to tumour immunity and a studied target forimmunotherapy.5 This study explores the immune land-scape of GBM, focusing on spatial relationships betweentumour-associated immune cells (TAICs) 6 and STING-expressing cells, uncovering patterns linked to prognosis.

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