[학회발표]2025년 춘계 신경외과학회 발표

[학회 구연발표]

발표분야 :신경중환자

발표자 :정현철 (Hyunchul Jung)

발표일: 2025년 4월 19일 토요일

장소: 대구 인터불고 호텔

소속: 서울아산병원 (Asan medical center)

저자 :김모이네,이승주,정현철,박원형,황준하,김재현,정연구,이시은,변준호,박중철,안재성

제목 (국문) :

급성 뇌내출혈 환자에서 칼슘 및 마그네슘 투여: 안전성 및 타당성 평가

제목 (영문) :

Administration of calcium and magnesium in acute intracerebral hemorrhage patients: assessing safety and feasibility

Purpose :

Serum calcium and magnesium levels are a key factor of the coagulation cascade and may potentially contribute to the pathophysiology of intracerebral hemorrhage (ICH) expansion. The aim of this study was to attain and sustain target levels of serum calcium and magnesium for three days following admission.

Methods :

A single-blind, prospective, multicenter randomized study was conducted from 2019 to 2022 years, enrolling acute ICH patients aged 18-80 years, with radiological diagnosis and without surgical intervention. Participants were randomly assigned in a 1:1 ratio to either the study group or the control group. In the study group, the target serum levels of calcium (9-10.2 mg/dL) and magnesium (2-3 mg/dL) were actively achieved and maintained for a duration of 3 days following admission. The primary outcome was the expansion of ICH volume within the first 3 days between the study group and the control groups.

Result :

After implementing inclusion/exclusion criteria, 105 of 354 patients remained in the study. There were no significant differences in ICH volume on hospital days 2 and 3 between the groups. Admission factors including Glasgow coma scale score, hemoglobin level, ICH volume, and spot sign showed significant correlations in multivariate analysis. On the third day of hospitalization, admission serum magnesium levels showed a significant correlation with ICH expansion, whereas calcium levels did not.

Conclusion :

Admission serum magnesium levels were found to correlate with hematoma expansion in patients with acute ICH. While magnesium itself may not be a direct therapeutic target, it could serve as a valuable indicator for identifying potential therapeutic strategies aimed at preventing ICH volume increase.